Seroprevalence of diphtheria and measles antibodies and their association with demographics, self-reported immunity, and immunogenetic factors in healthcare workers in Latvia

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dc.contributor.authorLeidere-Reine, Aija
dc.contributor.authorKolesova, Oksana
dc.contributor.authorKolesovs, Aleksandrs
dc.contributor.authorViksna, Ludmila
dc.contributor.institutionDepartment of Infectology
dc.contributor.institutionKlīniskās imunoloģijas un imunoģenētikas starpkatedru laboratorija
dc.contributor.institutionInstitute of Microbiology and Virology
dc.date.accessioned2022-08-16T21:02:35Z
dc.date.available2022-08-16T21:02:35Z
dc.date.issued2022-04
dc.descriptionFunding Information: The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: [Aija Leidere-Reine reports financial support was provided by European Social Fund and Latvian state budget. The study was partially funded by the project No 8.2.2.0/20/I/004 “Support for involving doctoral students in scientific research and studies”.] Publisher Copyright: © 2022 The Author(s)
dc.description.abstractLatvia is among European countries with outbreaks of diphtheria and measles. Healthcare workers (HCW) are exposed to infections and can transmit them to unvaccinated patients. We assessed the seroprevalence of antibodies against diphtheria and measles and their association with demographics, self-reported immunity, the presence of the HLA-B27 allele, and level of interferon regulatory factor 5 (IRF5) in Latvian HCW. Anti-diphtheria and anti-measles IgG antibodies and the level of IRF5 in serum were tested by enzyme immunoassay. The presence of the HLA-B27 allele was detected by a real-time polymerase chain reaction. The study involved 176 HCW, including 29% doctors and 44% nurses. Among HCW, 95.5% were seropositive for diphtheria. However, only 65.9% had full seroprotection against it. The seronegativity for measles (21.6%) was higher than for diphtheria (4.5%) without differences in gender and medical staff groups. Older age was associated with waning immunity against diphtheria and a higher rate of seropositivity for measles. Considered immunogenetic factors did not affect the level of antibodies, and variability of the level of IRF5 in serum can reflect ageing processes. Self-reported vaccination status had a low informative value regarding full seroprotection against diphtheria and seropositivity for measles indicating the need for pre-vaccination IgG screening in planning the booster vaccination.en
dc.description.statusPeer reviewed
dc.format.extent483620
dc.identifier.citationLeidere-Reine, A, Kolesova, O, Kolesovs, A & Viksna, L 2022, 'Seroprevalence of diphtheria and measles antibodies and their association with demographics, self-reported immunity, and immunogenetic factors in healthcare workers in Latvia', Vaccine: X, vol. 10, 100149. https://doi.org/10.1016/j.jvacx.2022.100149
dc.identifier.doi10.1016/j.jvacx.2022.100149
dc.identifier.issn2590-1362
dc.identifier.urihttps://dspace.rsu.lv/jspui/handle/123456789/9381
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=85125122307&partnerID=8YFLogxK
dc.language.isoeng
dc.relation.ispartofVaccine: X
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectHealthcare workers
dc.subjectHLA-B27
dc.subjectImmunity
dc.subjectIRF5
dc.subjectSeroprevalence
dc.subjectVaccine-preventable diseases
dc.subject3.1 Basic medicine
dc.subject3.2 Clinical medicine
dc.subject3.3 Health sciences
dc.subject1.1. Scientific article indexed in Web of Science and/or Scopus database
dc.subjectMolecular Medicine
dc.subjectGeneral Immunology and Microbiology
dc.subjectGeneral Veterinary
dc.subjectPublic Health, Environmental and Occupational Health
dc.subjectInfectious Diseases
dc.subjectSDG 3 - Good Health and Well-being
dc.titleSeroprevalence of diphtheria and measles antibodies and their association with demographics, self-reported immunity, and immunogenetic factors in healthcare workers in Latviaen
dc.type/dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article

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