Glutathione reductase is associated with the clinical outcome of septic shock in the patients treated using continuous veno-venous haemofiltration

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dc.contributor.authorMoisejevs, Georgijs
dc.contributor.authorBormane, Eva
dc.contributor.authorTrumpika, Dace
dc.contributor.authorBaufale, Regina
dc.contributor.authorBusmane, Inara
dc.contributor.authorVoicehovska, Julija
dc.contributor.authorGrigane, Anda
dc.contributor.authorSuba, Olegs
dc.contributor.authorSilova, Alise
dc.contributor.authorSkesters, Andrejs
dc.contributor.authorLejnieks, Aivars
dc.contributor.authorGailite, Linda
dc.contributor.authorBrigis, Girts
dc.contributor.institutionDepartment of Internal Diseases
dc.contributor.institutionBioķīmijas zinātniskā laboratorija
dc.contributor.institutionScientific Laboratory of Molecular Genetics
dc.contributor.institutionDepartment of Public Health and Epidemiology
dc.date.accessioned2021-08-05T10:05:01Z
dc.date.available2021-08-05T10:05:01Z
dc.date.issued2021-07-06
dc.descriptionPublisher Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland.
dc.description.abstractBackground and objectives: At present, there is insufficient evidence to support the use of continuous veno-venous haemofiltration (CVVH) in the early treatment of septic shock. This study focuses on the association between survival and different parameters of oxidative stress (RedOx). Thereby, we evaluated whether RedOx markers are associated with the outcome of septic shock in patients under early-initiated CVVH treatment. Materials and Methods: We conducted a prospective observational study of 65 patients with septic shock who started CVVH within 12 h after hospital admission. Blood samples were taken from each patient prior to the start of CVVH. The following RedOx markers were measured: glutathione peroxidase, glutathione reductase (GR), total antioxidant capacity, superoxide dismutase, nitric oxide, malondialdehyde and 4-hydroxynonenal. The odds ratio (OR) was calculated using binary logistic regression and stepwise multivariable regression. Results: The 65 patients had a median age of 66 years and 39 were male. Based on the outcome, the patients were divided into two groups—non-survivors (n = 29) and survivors (n = 36)—and the levels of RedOx markers were compared between them. Of all the markers, only higher GR activity was found to be significantly associated with the fatal outcome; 100.3 U/L versus 60.5 U/L, OR = 1.027 (95% CI, 1.010–1.044). Following adjustment for the sequential organ failure assessment score and other parameters, GR activity still presented a significant association with the fatal outcome, OR = 1.020 (95% CI, 1.002–1.038). Conclusions: GR activity is associated with in-hospital fatal outcomes among septic shock patients under early-initiated CVVH treatment. Septic shock patients who have a lower GR activity at hospital admission may have a favourable outcome of the early initiation of CVVH.en
dc.description.statusPeer reviewed
dc.format.extent8
dc.format.extent470986
dc.identifier.citationMoisejevs, G, Bormane, E, Trumpika, D, Baufale, R, Busmane, I, Voicehovska, J, Grigane, A, Suba, O, Silova, A, Skesters, A, Lejnieks, A, Gailite, L & Brigis, G 2021, 'Glutathione reductase is associated with the clinical outcome of septic shock in the patients treated using continuous veno-venous haemofiltration', Medicina (Lithuania), vol. 57, no. 7, 689. https://doi.org/10.3390/medicina57070689
dc.identifier.doi10.3390/medicina57070689
dc.identifier.issn1010-660X
dc.identifier.otherunpaywall: 10.3390/medicina57070689
dc.identifier.urihttps://dspace.rsu.lv/jspui/handle/123456789/5957
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=85110400367&partnerID=8YFLogxK
dc.language.isoeng
dc.relation.ispartofMedicina (Lithuania)
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectContinuous veno-venous haemofil-tration
dc.subjectGlutathione reductase
dc.subjectOxidative stress
dc.subjectSeptic shock
dc.subject3.2 Clinical medicine
dc.subject1.1. Scientific article indexed in Web of Science and/or Scopus database
dc.subjectGeneral Medicine
dc.titleGlutathione reductase is associated with the clinical outcome of septic shock in the patients treated using continuous veno-venous haemofiltrationen
dc.type/dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article

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