Potential effect of two different anaesthesia techniques on the activation of hhv-6 and hhv-7 infection in relation to changes in total lymphocyte count and peripheral immune cell distribution after prolonged microvascular free flap surgery

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dc.contributor.authorVilks, Arnis
dc.contributor.authorRasa, Santa
dc.contributor.authorDoniņa, Simona
dc.contributor.authorMurovska, Modra
dc.contributor.authorMamaja, Biruta
dc.contributor.institutionDepartment of Doctoral Studies
dc.contributor.institutionInstitute of Microbiology and Virology
dc.contributor.institutionDepartment of Anaesthesiology, Intensive Care and Clinical simulations
dc.date.accessioned2021-04-21T14:00:01Z
dc.date.available2021-04-21T14:00:01Z
dc.date.issued2014-12-01
dc.descriptionCopyright: Copyright 2015 Elsevier B.V., All rights reserved.
dc.description.abstractMicrovascular free flap surgery is a complex method of wound closure for large wounds. Tissue trauma, surgical stress and general anaesthesia are known immunosuppressors that may exacerbate postoperative infections. Beta-herpesviruses HHV-6 and HHV-7 are immunomodulating viruses highly prevalent in the population of healthy individuals, which can interfere with the function of the host immune system. These viruses can be reactivated in immunosuppressed conditions. The aim of this study was to monitor the potential effects of two different anaesthesia techniques - general anaesthesia (GA) and regional anaesthesia (RA) - on the activation of HHV-6 and HHV-7 infection in relation to changes in the total lymphocyte count and peripheral immune cell distribution after microvascular free flap surgery. We found significant increase in the frequency of active HHV-7 infection after surgery (p < 0.05) in the GA group. In the RA group changes were not significant. The activation of HHV-7 infection was associated with decrease in the total lymphocyte count post-operatively in patients from the GA group. The data of our study show that reconstructive flap surgery under GA is linked with more frequent postoperative lymphopenia, which is a potential post-operative immunosuppressor that probably triggers the activation of HHV-6 and HHV-7 infection.en
dc.description.statusPeer reviewed
dc.format.extent6
dc.format.extent165376
dc.identifier.citationVilks, A, Rasa, S, Doniņa, S, Murovska, M & Mamaja, B 2014, 'Potential effect of two different anaesthesia techniques on the activation of hhv-6 and hhv-7 infection in relation to changes in total lymphocyte count and peripheral immune cell distribution after prolonged microvascular free flap surgery', Proceedings of the Latvian Academy of Sciences, Section B: Natural, Exact, and Applied Sciences, vol. 68, no. 5-6, pp. 216-221. https://doi.org/10.2478/prolas-2014-0026
dc.identifier.doi10.2478/prolas-2014-0026
dc.identifier.issn1407-009X
dc.identifier.urihttps://dspace.rsu.lv/jspui/handle/123456789/3884
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=84921295291&partnerID=8YFLogxK
dc.language.isoeng
dc.relation.ispartofProceedings of the Latvian Academy of Sciences, Section B: Natural, Exact, and Applied Sciences
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectanaesthesia
dc.subjectHHV-6
dc.subjectHHV-7
dc.subjectlymphocytes
dc.subjectsurgery
dc.subject3.2 Clinical medicine
dc.subject1.1. Scientific article indexed in Web of Science and/or Scopus database
dc.subjectGeneral
dc.titlePotential effect of two different anaesthesia techniques on the activation of hhv-6 and hhv-7 infection in relation to changes in total lymphocyte count and peripheral immune cell distribution after prolonged microvascular free flap surgeryen
dc.type/dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article

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