Lack of Association between Rs2067474 Polymorphism in the Histamine Receptor H2 Gene and Gastric Cancer in Latvian Population

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dc.contributor.authorMoisejevs, Georgijs
dc.contributor.authorGailite, Linda
dc.contributor.authorIsajevs, Sergejs
dc.contributor.authorNikitina-Zaķe, Liene
dc.contributor.authorKempa, Inga
dc.contributor.authorJančiauskas, Dainius
dc.contributor.authorKikuste, Ilze
dc.contributor.authorSiviņš, Armands
dc.contributor.authorAncans, Guntis
dc.contributor.authorLeja, Marcis
dc.contributor.institutionScientific Laboratory of Molecular Genetics
dc.date.accessioned2021-05-06T12:40:03Z
dc.date.available2021-05-06T12:40:03Z
dc.date.issued2018-12-01
dc.descriptionFunding Information: The study was partly supported by the Latvian Government Research Programme BIOMEDICINE 2014–2017 Project Nr. 4 “Study of gastric cancer mortality reduction capability in Latvia”. Publisher Copyright: © 2018 Georgijs Moisejevs et al.
dc.description.abstractHistamine has an important role in the process of the gastric mucosa inflammation acting via histamine receptor H2 (encoded by the gene HRH2). Single nucleotide polymorphism of the enhancer element of HRH2 gene promoter rs2067474 (1018G>A)may be associated with changes of expression of the receptor. We attempted to clarify the association of this polymorphism with gastric cancer and/or atrophic gastritis in the Latvian (Caucasian) population. The study group consisted of 121 gastric cancer patients and 650 patients with no evidence of gastric neoplasia on upper gastrointestinal endoscopy. Genotyping for rs2067474 was performed with the TaqMan probe-based system using a commercially available probe for RT-PCR. The frequency of the A allele in the gastric cancer group was 0.41% and in the control group - 1.54% (p = 0.231). No significant differences were found comparing genotypes between gastric cancer versus control patients (OR = 0.236, CI95% = 0.030-1.896), patients with (n = 165) versus without (n = 485) gastric metaplastic lesions (OR = 0.854, CI95% = 0.288-2.540) and patients with (n = 297) and without (n = 353) gastric atrophic lesions (OR = 1.145, CI95% = 0.451-2.906). Our findings suggest that the HRH2 -1018G>A polymorphism (rs2067474) is neither associated with gastric cancer nor the grade of atrophic gastritis in the Latvian (Caucasian) population.en
dc.description.statusPeer reviewed
dc.format.extent6
dc.format.extent330085
dc.identifier.citationMoisejevs, G, Gailite, L, Isajevs, S, Nikitina-Zaķe, L, Kempa, I, Jančiauskas, D, Kikuste, I, Siviņš, A, Ancans, G & Leja, M 2018, 'Lack of Association between Rs2067474 Polymorphism in the Histamine Receptor H2 Gene and Gastric Cancer in Latvian Population', Proceedings of the Latvian Academy of Sciences, Section B: Natural, Exact, and Applied Sciences, vol. 72, no. 6, pp. 307-312. https://doi.org/10.2478/prolas-2018-0044
dc.identifier.doi10.2478/prolas-2018-0044
dc.identifier.issn1407-009X
dc.identifier.urihttps://dspace.rsu.lv/jspui/handle/123456789/4113
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=85059567250&partnerID=8YFLogxK
dc.language.isoeng
dc.relation.ispartofProceedings of the Latvian Academy of Sciences, Section B: Natural, Exact, and Applied Sciences
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectchronic gastritis
dc.subjectgastric cancer
dc.subjectgenetic polymorphism
dc.subjecthistamine H2 receptor
dc.subject3.1 Basic medicine
dc.subject1.1. Scientific article indexed in Web of Science and/or Scopus database
dc.subjectGeneral
dc.subjectSDG 3 - Good Health and Well-being
dc.titleLack of Association between Rs2067474 Polymorphism in the Histamine Receptor H2 Gene and Gastric Cancer in Latvian Populationen
dc.type/dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article

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