Structural studies of chromosomally encoded outer surface lipoprotein BB0158 from Borrelia burgdorferi sensu stricto

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dc.contributor.authorBrangulis, Kalvis
dc.contributor.authorAkopjana, Inara
dc.contributor.authorBogans, Janis
dc.contributor.authorKazaks, Andris
dc.contributor.authorTars, Kaspars
dc.date.accessioned2023-11-29T16:05:01Z
dc.date.available2023-11-29T16:05:01Z
dc.date.issued2024-01
dc.descriptionPublisher Copyright: © 2023 The Author(s)
dc.description.abstractLyme disease, or also known as Lyme borreliosis, is caused by the spirochetes belonging to the Borrelia burgdorferi sensu lato complex, which can enter the human body following the bite of an infected tick. Many membrane lipid-bound proteins, also known as lipoproteins, are located on the surface of B. burgdorferi sensu lato and play a crucial role in the spirochete to interact with its environment, whether in ticks or mammals. Since the spirochete needs to perform various tasks, such as resisting the host's immune system or spreading throughout the organism, it is not surprising that numerous surface proteins have been found to be essential for B. burgdorferi sensu lato complex bacteria in causing Lyme disease. In this study, we have determined (at 2.4 Å resolution) and characterized the 3D structure of BB0158, one of the few chromosomally encoded outer surface proteins from B. burgdorferi sensu stricto. BB0158 belongs to the paralogous gene family 44 (PFam44), consisting of four other members (BB0159, BBA04, BBE09 and BBK52). The characterization of BB0158, which appears to form a domain-swapped dimer, in conjunction with the characterization of the corresponding PFam44 members, certainly contribute to our understanding of B. burgdorferi sensu stricto proteins.en
dc.description.statusPeer reviewed
dc.format.extent9
dc.format.extent8534848
dc.identifier.citationBrangulis, K, Akopjana, I, Bogans, J, Kazaks, A & Tars, K 2024, 'Structural studies of chromosomally encoded outer surface lipoprotein BB0158 from Borrelia burgdorferi sensu stricto', Ticks and Tick-borne Diseases, vol. 15, no. 1, 102287. https://doi.org/10.1016/j.ttbdis.2023.102287
dc.identifier.doi10.1016/j.ttbdis.2023.102287
dc.identifier.issn1877-959X
dc.identifier.urihttps://dspace.rsu.lv/jspui/handle/123456789/15017
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=85178384604&partnerID=8YFLogxK
dc.language.isoeng
dc.relation.ispartofTicks and Tick-borne Diseases
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectLyme borreliosis
dc.subjectSpirochetes
dc.subjectX-ray crystallography
dc.subject1.6 Biological sciences
dc.subject3.1 Basic medicine
dc.subject1.1. Scientific article indexed in Web of Science and/or Scopus database
dc.subjectSDG 3 - Good Health and Well-being
dc.titleStructural studies of chromosomally encoded outer surface lipoprotein BB0158 from Borrelia burgdorferi sensu strictoen
dc.type/dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article

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