Idiopathic infertility as a feature of genome instability

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dc.contributor.authorPuzuka, Agrita
dc.contributor.authorAlksere, Baiba
dc.contributor.authorGailite, Linda
dc.contributor.authorErenpreiss, Juris
dc.contributor.institutionScientific Laboratory of Molecular Genetics
dc.contributor.institutionDepartment of Biology and Microbiology
dc.date.accessioned2021-08-23T11:20:01Z
dc.date.available2021-08-23T11:20:01Z
dc.date.issued2021-06-29
dc.descriptionFunding Information: The authors are very grateful to habil. med. Jekaterina Erenpreisa for her critical review of the paper. Publisher Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland.
dc.description.abstractGenome instability may play a role in severe cases of male infertility, with disrupted spermatogenesis being just one manifestation of decreased general health and increased morbidity. Here, we review the data on the association of male infertility with genetic, epigenetic, and environmental alterations, the causes and consequences, and the methods for assessment of genome instability. Male infertility research has provided evidence that spermatogenic defects are often not limited to testicular dysfunction. An increased incidence of urogenital disorders and several types of cancer, as well as overall reduced health (manifested by decreased life expectancy and increased morbidity) have been reported in infertile men. The pathophysiological link between decreased life expectancy and male infertility supports the notion of male infertility being a systemic rather than an isolated condition. It is driven by the accumulation of DNA strand breaks and premature cellular senescence. We have presented extensive data supporting the notion that genome instability can lead to severe male infertility termed “idiopathic oligo-astheno-teratozoospermia.” We have detailed that genome instability in men with oligo-astheno-teratozoospermia (OAT) might depend on several genetic and epigenetic factors such as chromosomal heterogeneity, aneuploidy, micronucleation, dynamic mutations, RT, PIWI/piRNA regulatory pathway, pathogenic allelic variants in repair system genes, DNA methylation, environmental aspects, and lifestyle factors.en
dc.description.statusPeer reviewed
dc.format.extent13
dc.format.extent657292
dc.identifier.citationPuzuka, A, Alksere, B, Gailite, L & Erenpreiss, J 2021, 'Idiopathic infertility as a feature of genome instability', Life, vol. 11, no. 7, 628. https://doi.org/10.3390/life11070628
dc.identifier.doi10.3390/life11070628
dc.identifier.otherunpaywall: 10.3390/life11070628
dc.identifier.urihttps://dspace.rsu.lv/jspui/handle/123456789/6059
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=85109374109&partnerID=8YFLogxK
dc.language.isoeng
dc.relation.ispartofLife
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectDNA breaks
dc.subjectGenome instability
dc.subjectMale infertility
dc.subject1.6 Biological sciences
dc.subject3.1 Basic medicine
dc.subject1.1. Scientific article indexed in Web of Science and/or Scopus database
dc.subjectEcology, Evolution, Behavior and Systematics
dc.subjectGeneral Biochemistry,Genetics and Molecular Biology
dc.subjectSpace and Planetary Science
dc.subjectPalaeontology
dc.subjectSDG 3 - Good Health and Well-being
dc.titleIdiopathic infertility as a feature of genome instabilityen
dc.type/dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/systematicreview

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