Commercial articulated collaborative in situ 3D bioprinter for skin wound healing

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dc.contributor.authorLevin, Aleksandr A
dc.contributor.authorKaralkin, Pavel A.
dc.contributor.authorKoudan, Elizaveta V.
dc.contributor.authorSenatov, Fedor S.
dc.contributor.authorParfenov, Vladislav A.
dc.contributor.authorLvov, Vladislav
dc.contributor.authorPetrov, Stanislav
dc.contributor.authorPereira, Frederiko D.A.S.
dc.contributor.authorKovalev, Alexey V.
dc.contributor.authorOsidak, Egor
dc.contributor.authorDomogatsky, Sergey P.
dc.contributor.authorManturova, Natalya E.
dc.contributor.authorKasyanov, Vladimir
dc.contributor.authorSergeeva, Natalia S.
dc.contributor.authorZorin, Vadim L.
dc.contributor.authorKhesuani, Yusef D.
dc.contributor.authorMironov, Vladimir A.
dc.contributor.institutionJoint Laboratory of Traumatology and Orthopaedics
dc.date.accessioned2023-02-13T09:50:02Z
dc.date.available2023-02-13T09:50:02Z
dc.date.issued2023-01-31
dc.descriptionFunding Information: This work was funded by the Ministry of Science and Higher Education of the Russian Federation under the strategic academic leadership program “Priority 2030.” Publisher Copyright: © 2023 Author(s). This is an Open Access article distributed under the terms of the Creative Commons Attribution License, permitting distribution, and reproduction in any medium, provided the original work is properly cited
dc.description.abstractIn situ bioprinting is one of the most clinically relevant techniques in the emerging bioprinting technology because it could be performed directly on the human body in the operating room and it does not require bioreactors for post-printing tissue maturation. However, commercial in situ bioprinters are still not available on the market. In this study, we demonstrated the benefit of the originally developed first commercial articulated collaborative in situ bioprinter for the treatment of full-thickness wounds in rat and porcine models. We used an articulated and collaborative robotic arm from company KUKA and developed original printhead and correspondence software enabling in situ bioprinting on curve and moving surfaces. The results of in vitro and in vivo experiments show that in situ bioprinting of bioink induces a strong hydrogel adhesion and enables printing on curved surfaces of wet tissues with a high level of fidelity. The in situ bioprinter was convenient to use in the operating room. Additional in vitro experiments (in vitro collagen contraction assay and in vitro 3D angiogenesis assay) and histological analyses demonstrated that in situ bioprinting improves the quality of wound healing in rat and porcine skin wounds.en
dc.description.statusPeer reviewed
dc.format.extent14
dc.format.extent4925911
dc.identifier.citationLevin, A A, Karalkin, P A, Koudan, E V, Senatov, F S, Parfenov, V A, Lvov, V, Petrov, S, Pereira, F D A S, Kovalev, A V, Osidak, E, Domogatsky, S P, Manturova, N E, Kasyanov, V, Sergeeva, N S, Zorin, V L, Khesuani, Y D & Mironov, V A 2023, 'Commercial articulated collaborative in situ 3D bioprinter for skin wound healing', International Journal of Bioprinting, vol. 9, no. 2, 675, pp. 380-393. https://doi.org/10.18063/ijb.v9i2.675
dc.identifier.doi10.18063/ijb.v9i2.675
dc.identifier.issn2424-8002
dc.identifier.otherMendeley: c31551f6-e7b1-3b93-812d-2a7a95df28ba
dc.identifier.urihttps://dspace.rsu.lv/jspui/handle/123456789/10362
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=85148208236&partnerID=8YFLogxK
dc.language.isoeng
dc.relation.ispartofInternational Journal of Bioprinting
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectIn situ bioprinting
dc.subjectwound healing
dc.subjectCollagen hydrogel
dc.subject3.4 Medical biotechnology
dc.subject1.1. Scientific article indexed in Web of Science and/or Scopus database
dc.titleCommercial articulated collaborative in situ 3D bioprinter for skin wound healingen
dc.type/dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article

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