A pilot study on markers of genetic predisposition in tuberculous pneumonia patients in Latgale
No Thumbnail Available
Date
2019-05-01
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
Tuberculosis (TB) is still one of the top ten leading causes of death in the world. Compared to other Baltic and Eastern European countries, TB incidence (24.8 new cases per 100 000 people in 2017) in Latvia is relatively high. One of the regions with the highest TB incidence is Latgale (31.1 cases per 100 000 people). The aim of this pilot study was to identify markers of genetic predisposition to TB in Latgale. The study included 26 patients (16 males and 10 females) aged between 18 and 85 with bilateral TB pneumonia and without HIV infection. HLA typing was performed in HLA-DRB1, -DQA1, and -DQB1 loci by a polymerase chain reaction with low resolution sequence-specific primers. HLA-DRB1∗07 and HLA-DRB1∗11 alleles were identified as risk alleles for TB. HLA-DRB1∗15 allele was a protective allele. Due to the limitations of this exploratory study, a broader study needs to be conducted to revealing specific risk and protective HLA Class II alleles for TB in the subpopulation of Latgale.
Description
Publisher Copyright: © 2019 Ksenija Kramiča et al., published by Sciendo 2019. Copyright: Copyright 2019 Elsevier B.V., All rights reserved.
Keywords
HLA Class II, Latgale, tuberculosis, 1.6 Biological sciences, 3.1 Basic medicine, 3.2 Clinical medicine, 1.1. Scientific article indexed in Web of Science and/or Scopus database, General, SDG 3 - Good Health and Well-being
Citation
Kramiča, K, Eglite, J, Koļesovs, A, Kramiča, T, Titoviča, G, Džeriņa, D, Nikolajeva, G, Viksna, L & Koļesova, O 2019, 'A pilot study on markers of genetic predisposition in tuberculous pneumonia patients in Latgale', Proceedings of the Latvian Academy of Sciences, Section B: Natural, Exact, and Applied Sciences, vol. 73, no. 2, pp. 189-191. https://doi.org/10.2478/prolas-2019-0030