Breath Fingerprint of Colorectal Cancer Patients Based on the Gas Chromatography–Mass Spectrometry Analysis

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dc.contributor.authorKononova, Elīna
dc.contributor.authorMežmale, Linda
dc.contributor.authorPoļaka, Inese
dc.contributor.authorVeliks, Viktors
dc.contributor.authorAnarkulova, Linda
dc.contributor.authorVilkoite, Ilona
dc.contributor.authorTolmanis, Ivars
dc.contributor.authorĻeščinska, Anna Marija
dc.contributor.authorStonāns, Ilmārs
dc.contributor.authorPčolkins, Andrejs
dc.contributor.authorMochalski, Pawel
dc.contributor.authorLeja, Mārcis
dc.contributor.institutionDepartment of Doctoral Studies
dc.contributor.institutionFaculty of Medicine
dc.date.accessioned2025-02-21T13:00:03Z
dc.date.available2025-02-21T13:00:03Z
dc.date.issued2024-02
dc.descriptionPublisher Copyright: © 2024 by the authors.
dc.description.abstractThe human body emits a multitude of volatile organic compounds (VOCs) via tissues and various bodily fluids or exhaled breath. These compounds collectively create a distinctive chemical profile, which can potentially be employed to identify changes in human metabolism associated with colorectal cancer (CRC) and, consequently, facilitate the diagnosis of this disease. The main goal of this study was to investigate and characterize the VOCs’ chemical patterns associated with the breath of CRC patients and controls and identify potential expiratory markers of this disease. For this purpose, gas chromatography–mass spectrometry was applied. Collectively, 1656 distinct compounds were identified in the breath samples provided by 152 subjects. Twenty-two statistically significant VOCs (p-xylene; hexanal; 2-methyl-1,3-dioxolane; 2,2,4-trimethyl-1,3-pentanediol diisobutyrate; hexadecane; nonane; ethylbenzene; cyclohexanone; diethyl phthalate; 6-methyl-5-hepten-2-one; tetrahydro-2H-pyran-2-one; 2-butanone; benzaldehyde; dodecanal; benzothiazole; tetradecane; 1-dodecanol; 1-benzene; 3-methylcyclopentyl acetate; 1-nonene; toluene) were observed at higher concentrations in the exhaled breath of the CRC group. The elevated levels of these VOCs in CRC patients’ breath suggest the potential for these compounds to serve as biomarkers for CRC.en
dc.description.statusPeer reviewed
dc.format.extent987970
dc.identifier.citationKononova, E, Mežmale, L, Poļaka, I, Veliks, V, Anarkulova, L, Vilkoite, I, Tolmanis, I, Ļeščinska, A M, Stonāns, I, Pčolkins, A, Mochalski, P & Leja, M 2024, 'Breath Fingerprint of Colorectal Cancer Patients Based on the Gas Chromatography–Mass Spectrometry Analysis', International Journal of Molecular Sciences, vol. 25, no. 3, 1632. https://doi.org/10.3390/ijms25031632
dc.identifier.doi10.3390/ijms25031632
dc.identifier.issn1661-6596
dc.identifier.urihttps://dspace.rsu.lv/jspui/handle/123456789/17110
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=85184680604&partnerID=8YFLogxK
dc.language.isoeng
dc.relation.ispartofInternational Journal of Molecular Sciences
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectbreath test
dc.subjectcolorectal cancer
dc.subjectCRC
dc.subjectCRC marker
dc.subjectGC-MS
dc.subjectscreening
dc.subjectVOCs
dc.subjectvolatile organic compounds
dc.subject3.2 Clinical medicine
dc.subject3.1 Basic medicine
dc.subject1.1. Scientific article indexed in Web of Science and/or Scopus database
dc.subjectCatalysis
dc.subjectMolecular Biology
dc.subjectSpectroscopy
dc.subjectComputer Science Applications
dc.subjectPhysical and Theoretical Chemistry
dc.subjectOrganic Chemistry
dc.subjectInorganic Chemistry
dc.subjectSDG 3 - Good Health and Well-being
dc.titleBreath Fingerprint of Colorectal Cancer Patients Based on the Gas Chromatography–Mass Spectrometry Analysisen
dc.type/dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article

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