Case Report - Stauffer’s Syndrome in Patient with Metastatic Prostate Cancer
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Date
2020
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Volume Title
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Rīgas Stradiņa universitāte
Rīga Stradiņš University
Rīga Stradiņš University
Abstract
Holestāze ir simptoms, kas var būt daudzas patoloģijas, piemēram, žultsvada aizsprostojums ļaundabīgu masu ietekmē, žultsakmeņu aizsprostojums, akūts un hronisks vīrusu hepatīts un autoimūnas slimības, piemēram, primārā žultsceļu un sklerozējošais holangīts. Staufers sindroms ir reti sastopams paraneoplastiskā sindroma veids, kas izpaužas, kā holestāze bez primāras slimības. Nieru šūnu vēža pacientiem ir aprakstīts klasisks Stauffer sindroms. Literatūrā holestāze, kā paraneoplastiskā sindroma izpausme aprakstīta arī pacientiem ar prostatas adenokarcinomu un aizkuņģa dziedzera un bronhogēno karcinomu. Secinājumi. Pacientiem, kuriem ir holestāze bez pamata cēloņa, jāpatur prātā Stauffer sindroms. Mēs iesakām izslēgt iespējamos holestāzes cēloņus, piemēram, žultsvada aizsprostojumu.
Cholestasis is a symptom that can be present in many conditions, such as bile duct obstruction by malignant mases, obstruction by gallstone, acute and chronic viral hepatitis, and autoimmune disorders, such as primary biliary and sclerosing cholangitis. Stauffer syndrome is a rare type of paraneoplastic syndrome that presents as cholestasis with absence of underlying disease. Classically Stauffer syndrome has been described in renal cell cancer patients. In literature cholestasis as manifestation of paraneoplastic syndrome has also been described in patients with prostate adenocarcinoma and pancreatic and bronchogenic carcinoma. Conclusions. Stauffer syndrome should be kept in mind in patients who present with cholestasis with no underlying cause. We advise to exclude any possible causes of cholestasis, for example, obstruction of bile duct.
Cholestasis is a symptom that can be present in many conditions, such as bile duct obstruction by malignant mases, obstruction by gallstone, acute and chronic viral hepatitis, and autoimmune disorders, such as primary biliary and sclerosing cholangitis. Stauffer syndrome is a rare type of paraneoplastic syndrome that presents as cholestasis with absence of underlying disease. Classically Stauffer syndrome has been described in renal cell cancer patients. In literature cholestasis as manifestation of paraneoplastic syndrome has also been described in patients with prostate adenocarcinoma and pancreatic and bronchogenic carcinoma. Conclusions. Stauffer syndrome should be kept in mind in patients who present with cholestasis with no underlying cause. We advise to exclude any possible causes of cholestasis, for example, obstruction of bile duct.
Description
Medicīna
Medicine
Veselības aprūpe
Health Care
Medicine
Veselības aprūpe
Health Care
Keywords
Staufera sindroms, Stauffer syndrome