Emerging blood-based biomarkers for detection of gastric cancer

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dc.contributor.authorKalnina, Zane
dc.contributor.authorMeistere, Irena
dc.contributor.authorKikuste, Ilze
dc.contributor.authorTolmanis, Ivars
dc.contributor.authorZayakin, Pawel
dc.contributor.authorLine, Aija
dc.date.accessioned2022-02-07T13:50:02Z
dc.date.available2022-02-07T13:50:02Z
dc.date.issued2015-11-07
dc.descriptionPublisher Copyright: © 2015 Baishideng Publishing Group Inc. All rights reserved.
dc.description.abstractEarly detection and efficient monitoring of tumor dynamics are prerequisites for reducing disease burden and mortality, and for improving the management of patients with gastric cancer (GC). Blood-based biomarker assays for the detection of early-stage GC could be of great relevance both for population-wide or risk groupbased screening programs, while circulating biomarkers that reflect the genetic make-up and dynamics of the tumor would allow monitoring of treatment efficacy, predict recurrences and assess the genetic heterogeneity of the tumor. Recent research to identify blood-based biomarkers of GC has resulted in the identification of a wide variety of cancer-associated molecules, including various proteins, autoantibodies against tumor associated antigens, cell-free DNA fragments, mRNAs and various non-coding RNAs, circulating tumor cells and cancer-derived extracellular vesicles. Each type of these biomarkers provides different information on the disease status, has different advantages and disadvantages, and distinct clinical usefulness. In the current review, we summarize the recent developments in blood-based GC biomarker discovery, discuss the origin of various types of biomarkers and their clinical usefulness and the technological challenges in the development of biomarker assays for clinical use.en
dc.description.statusPeer reviewed
dc.format.extent18
dc.format.extent1255766
dc.identifier.citationKalnina, Z, Meistere, I, Kikuste, I, Tolmanis, I, Zayakin, P & Line, A 2015, 'Emerging blood-based biomarkers for detection of gastric cancer', World Journal of Gastroenterology, vol. 21, no. 41, pp. 11636-11653. https://doi.org/10.3748/wjg.v21.i41.11636
dc.identifier.doi10.3748/wjg.v21.i41.11636
dc.identifier.issn1007-9327
dc.identifier.urihttps://dspace.rsu.lv/jspui/handle/123456789/7561
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=84947224850&partnerID=8YFLogxK
dc.language.isoeng
dc.relation.ispartofWorld Journal of Gastroenterology
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAutoantibodies
dc.subjectBiomarker
dc.subjectCell-free DNA
dc.subjectCell-free RNA
dc.subjectExtracellular vesicles
dc.subjectGastric cancer
dc.subjectLiquid biopsy
dc.subjectProteomics
dc.subject3.1 Basic medicine
dc.subject3.2 Clinical medicine
dc.subject1.1. Scientific article indexed in Web of Science and/or Scopus database
dc.subjectGastroenterology
dc.subjectSDG 3 - Good Health and Well-being
dc.titleEmerging blood-based biomarkers for detection of gastric canceren
dc.type/dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article

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