Combined medical treatment of chronic pancreatitis

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dc.contributor.authorUmnova, Larisa
dc.contributor.authorOrlikovs, Grigorijs
dc.contributor.authorVoicehovska, Julija
dc.contributor.authorVoicehovskis, Vladimirs
dc.contributor.authorKrustiņš, Eduards
dc.contributor.institutionDepartment of Internal Diseases
dc.date.accessioned2021-07-01T08:00:01Z
dc.date.available2021-07-01T08:00:01Z
dc.date.issued2015-04-01
dc.descriptionFunding Information: This study was supported by ESF project Nr. 2009/0147/1DP/1.1.2.1.2/09/IPIA/VIAA/009.
dc.description.abstractThe aim of the study was to determine the most effective medical treatment of patients with chronic pancreatitis, by using either pancreatin alone or in combination with proton pump inhibitor (PPI) or PPI and non-steroidal anti-inflammatory drug (NSAID). Patients with chronic pancreatitis, who did not require a surgical treatment, received medical treatment for a one-month period: 20 patients received pancreatin monotherapy; 48 patients were given a combination of pancreatin and PPI; 38 patients were treated with a combination of pancreatin, PPI and NSAID (PNP therapy group). In comparison with other groups, patients in the PNP therapy group showed improvement in body mass index, abdominal pain, bowel movements, chronic pancreatitis severity, as well as their quality of life assessment (p < 0.05). The combination of pancreatin, PPI and NSAID was the most effective among those applied in chronic pancreatitis patient treatment. A one-month long course of this therapy was safe and did not cause any significant adverse effects. The combination of pancreatin, PPI and NSAID for treatment of chronic pancreatitis can be recommended, as it is based on pathogenesis of the disease, effective, safe and economically advantageous.en
dc.description.statusPeer reviewed
dc.format.extent7
dc.format.extent224246
dc.identifier.citationUmnova, L, Orlikovs, G, Voicehovska, J, Voicehovskis, V & Krustiņš, E 2015, 'Combined medical treatment of chronic pancreatitis', Proceedings of the Latvian Academy of Sciences, Section B: Natural, Exact, and Applied Sciences, vol. 69, no. 1/2, pp. 20-26. https://doi.org/10.2478/prolas-2014-0012
dc.identifier.doi10.2478/prolas-2014-0012
dc.identifier.issn1407-009X
dc.identifier.urihttps://dspace.rsu.lv/jspui/handle/123456789/5781
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=84947917504&partnerID=8YFLogxK
dc.language.isoeng
dc.relation.ispartofProceedings of the Latvian Academy of Sciences, Section B: Natural, Exact, and Applied Sciences
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectMedical treatment of chronic pancreatitis
dc.subjectPanccreatic index
dc.subjectQuality of life
dc.subject3.2 Clinical medicine
dc.subject1.1. Scientific article indexed in Web of Science and/or Scopus database
dc.subjectGeneral
dc.titleCombined medical treatment of chronic pancreatitisen
dc.type/dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article

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