Brodmann Areas, V1 Atlas and Cognitive Impairment : Assessing Cortical Thickness for Cognitive Impairment Diagnostics

Simple item page
dc.contributor.authorTrišins, Maksims
dc.contributor.authorZdanovskis, Nauris
dc.contributor.authorPlatkājis, Ardis
dc.contributor.authorŠneidere, Kristīne
dc.contributor.authorKostiks, Andrejs
dc.contributor.authorKarelis, Guntis
dc.contributor.authorStepens, Ainārs
dc.contributor.institutionDepartment of Radiology
dc.contributor.institutionMilitārās medicīnas pētījumu un studiju centrs
dc.contributor.institutionDepartment of Health Psychology and Paedagogy
dc.contributor.institutionDepartment of Infectology
dc.date.accessioned2024-05-08T08:30:01Z
dc.date.available2024-05-08T08:30:01Z
dc.date.issued2024-04
dc.descriptionPublisher Copyright: © 2024 by the authors.
dc.description.abstractBackground and Objectives: Magnetic resonance imaging is vital for diagnosing cognitive decline. Brodmann areas (BA), distinct regions of the cerebral cortex categorized by cytoarchitectural variances, provide insights into cognitive function. This study aims to compare cortical thickness measurements across brain areas identified by BA mapping. We assessed these measurements among patients with and without cognitive impairment, and across groups categorized by cognitive performance levels using the Montreal Cognitive Assessment (MoCA) test.  Materials and Methods: In this cross-sectional study, we included 64 patients who were divided in two ways: in two groups with (CI) or without (NCI) impaired cognitive function and in three groups with normal (NC), moderate (MPG) and low (LPG) cognitive performance according to MoCA scores. Scans with a 3T MRI scanner were carried out, and cortical thickness data was acquired using Freesurfer 7.2.0 software.  Results: By analyzing differences between the NCI and CI groups cortical thickness of BA3a in left hemisphere (U = 241.000, p = 0.016), BA4a in right hemisphere (U = 269.000, p = 0.048) and BA28 in left hemisphere (U = 584.000, p = 0.005) showed significant differences. In the LPG, MPG and NC cortical thickness in BA3a in left hemisphere (H (2) = 6.268, p = 0.044), in V2 in right hemisphere (H (2) = 6.339, p = 0.042), in BA28 in left hemisphere (H (2) = 23.195, p < 0.001) and in BA28 in right hemisphere (H (2) = 10.015, p = 0.007) showed significant differences.  Conclusions: Our study found that cortical thickness in specific Brodmann Areas—BA3a and BA28 in the left hemisphere, and BA4a in the right—differ significantly between NCI and CI groups. Significant differences were also observed in BA3a (left), V2 (right), and BA28 (both hemispheres) across LPG, MPG, NC groups. Despite a small sample size, these findings suggest cortical thickness measurements can serve as effective biomarkers for cognitive impairment diagnosis, warranting further validation with a larger cohort.en
dc.description.statusPeer reviewed
dc.format.extent1230306
dc.identifier.citationTrišins, M, Zdanovskis, N, Platkājis, A, Šneidere, K, Kostiks, A, Karelis, G & Stepens, A 2024, 'Brodmann Areas, V1 Atlas and Cognitive Impairment : Assessing Cortical Thickness for Cognitive Impairment Diagnostics', Medicina (Lithuania), vol. 60, no. 4, 587. https://doi.org/10.3390/medicina60040587
dc.identifier.doi10.3390/medicina60040587
dc.identifier.issn1010-660X
dc.identifier.otherMendeley: c068b75a-fbc9-3d95-836d-b6dcd196c6f9
dc.identifier.urihttps://dspace.rsu.lv/jspui/handle/123456789/15469
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=85191354759&partnerID=8YFLogxK
dc.identifier.urlhttps://www.mendeley.com/catalogue/c068b75a-fbc9-3d95-836d-b6dcd196c6f9/
dc.language.isoeng
dc.relation.ispartofMedicina (Lithuania)
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAlzheimer’s disease
dc.subjectatlas-based segmentation
dc.subjectBrodmann areas
dc.subjectcognition
dc.subjectcortical thickness
dc.subjectdementia
dc.subjectmild cognitive impairment
dc.subjectneuroimaging
dc.subjectstructural MRI
dc.subject3.2 Clinical medicine
dc.subject1.1. Scientific article indexed in Web of Science and/or Scopus database
dc.subjectGeneral Medicine
dc.titleBrodmann Areas, V1 Atlas and Cognitive Impairment : Assessing Cortical Thickness for Cognitive Impairment Diagnosticsen
dc.type/dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article

Files

Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
medicina-60-00587-v2.pdf
Size:
1.17 MB
Format:
Adobe Portable Document Format
Download

Collections

Research outputs from Pure / Zinātniskās darbības rezultāti no ZDIS Pure