Prevalence and risk factors of infection with high risk human papilloma viruses among hiv-positive women with clinical manifestations of tuberculosis in a middle-income country

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dc.contributor.authorIsaguliants, Maria
dc.contributor.authorNosik, Marina
dc.contributor.authorKarlsen, Anastasia
dc.contributor.authorPetrakova, Natalia
dc.contributor.authorEnaeva, Marina
dc.contributor.authorLebedeva, Natalia
dc.contributor.authorPodchufarova, Daria
dc.contributor.authorLaga, Vita
dc.contributor.authorGromov, Konstantin
dc.contributor.authorNazarov, Anatoly
dc.contributor.authorChowdhury, Sona
dc.contributor.authorSinitsyn, Mikhail
dc.contributor.authorSobkin, Alexander
dc.contributor.authorChistyakova, Natalya
dc.contributor.authorAleshina, Svetlana
dc.contributor.authorGrabarnik, Alexei
dc.contributor.authorPalefsky, Joel M.
dc.contributor.institutionInstitute of Microbiology and Virology
dc.date.accessioned2022-01-26T13:45:01Z
dc.date.available2022-01-26T13:45:01Z
dc.date.issued2021-06
dc.descriptionFunding Information: RFBR 17-54-30002; R01 CA217715/CA/NCI NIH HHS/United States. Publisher Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland.
dc.description.abstractWomen living with HIV-1 are at high risk of infection with human papillomavirus of high carcinogenic risk (HR HPVs). M. tuberculosis (TB) promotes HPV infection and increases the risk to develop HPV-associated cancer. Our knowledge of persisting HR HPVs genotypes, and of the factors promoting HR HPV infection in people living with HIV-1 with clinical TB manifestations is sparse. Here, we analyzed 58 women living with HIV-1 with clinical TB manifestations (WLWH with TB) followed up in specialized centers in Russia, a middle income country endemic for HIV-1 and TB, for the presence in cervical smears of DNA of twelve HR HPV genotypes. DNA encoding HPV16 E5, E6/E7 was sequenced. Sociodemographic data of patients was collected by questionnaire. All women were at C2-C3 stages of HIV-infection (by CDC). The majority were over 30 years old, had secondary education, were unemployed, had sexual partners, experienced 2–3 pregnancies and at least one abortion, and were smokers. The most prevalent was HPV16 detected in the cervical smears of 38% of study participants. Altogether 34.5% of study participants were positive for HR HPV types other than HPV16; however, but none of these types was seen in more than 7% of tested samples. Altogether, 20.7% of study participants were positive for several HR HPV types. Infections with HPVs other than HPV16 were common among WLWH with generalized TB receiving combined ART/TB-therapy, and associated with their ability to work, indirectly reflecting both their health and lifestyle. The overall prevalence of HR HPVs was associated with sexual activity of women reflected by the number of pregnancies, and of HPV 16, with young age; none was associated to CD4+-counts, route of HIV-infection, duration of life with HIV, forms of TB-infection, or duration of ART, characterizing the immune status. Thus, WLWH with TB—especially young—were predisposed to infection with HPV16, advancing it as a basis for a therapeutic HPV vaccine. Phylogenetic analysis of HPV16 E5, E6/E7 DNA revealed no common ancestry; sequences were similar to those of the European and American HPV16 strains, indicating that HPV vaccine for WLWH could be the same as HPV16 vaccines developed for the general population. Sociodemographic and health correlates of HR HPV prevalence in WLWH deserve further analysis to develop criteria/recommendations for prophylactic catch-up and therapeutic HPV vaccination of this highly susceptible and vulnerable population group.en
dc.description.statusPeer reviewed
dc.format.extent2493586
dc.identifier.citationIsaguliants, M, Nosik, M, Karlsen, A, Petrakova, N, Enaeva, M, Lebedeva, N, Podchufarova, D, Laga, V, Gromov, K, Nazarov, A, Chowdhury, S, Sinitsyn, M, Sobkin, A, Chistyakova, N, Aleshina, S, Grabarnik, A & Palefsky, J M 2021, 'Prevalence and risk factors of infection with high risk human papilloma viruses among hiv-positive women with clinical manifestations of tuberculosis in a middle-income country', Biomedicines , vol. 9, no. 6, 683. https://doi.org/10.3390/biomedicines9060683
dc.identifier.doi10.3390/biomedicines9060683
dc.identifier.issn2227-9059
dc.identifier.urihttps://dspace.rsu.lv/jspui/handle/123456789/7302
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=85108885278&partnerID=8YFLogxK
dc.language.isoeng
dc.relation.ispartofBiomedicines
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAIDS
dc.subjectART and TB treatment
dc.subjectClinical TB manifestations
dc.subjectM. tuberculosis
dc.subjectPrevalence of high risk HPVs
dc.subjectSequence of HPV 16 E6 and E7
dc.subjectSociodemographic characteristics
dc.subjectTherapeutic HPV vaccine
dc.subjectWomen living with HIV-1
dc.subject1.6 Biological sciences
dc.subject3.1 Basic medicine
dc.subject3.2 Clinical medicine
dc.subject1.1. Scientific article indexed in Web of Science and/or Scopus database
dc.subjectMedicine (miscellaneous)
dc.subjectGeneral Biochemistry,Genetics and Molecular Biology
dc.subjectSDG 3 - Good Health and Well-being
dc.titlePrevalence and risk factors of infection with high risk human papilloma viruses among hiv-positive women with clinical manifestations of tuberculosis in a middle-income countryen
dc.type/dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article

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