Lyme disease and associated nmdar encephalitis : A case report and literature review
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Date
2021-09-28
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Abstract
We present a case of a patient with positive N-methyl-D-aspartate receptor (NMDAR) IgG antibodies in their serum and cerebrospinal fluid (CSF) associated with neuroborreliosis. Clinically, the patient presented with symptoms of confusion, as well as behavioral and speech impairments. Regardless of antibacterial treatment, no significant improvement was achieved. Methylprednisolone provided a marked improvement in the patient’s clinical signs and CSF findings. The screening did not reveal any underlying neoplasm. Taking into account the marked clinical improvement after treatment with glucocorticosteroids, we suggest that NMDAR encephalitis is a possible autoimmune complication in neuroborreliosis patients requiring additional immunotherapy.
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Funding Information: This research publication was cost by Riga Stradins University, Riga, Latvia. Publisher Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland.
Keywords
Autoimmune encephalitis, Lyme disease, Neuroborreliosis, NMDAR antibodies, NMDAR encephalitis, 3.2 Clinical medicine, 1.1. Scientific article indexed in Web of Science and/or Scopus database, Clinical Neurology
Citation
Predkele, N & Mednieks, J 2021, 'Lyme disease and associated nmdar encephalitis : A case report and literature review', Neurology International, vol. 13, no. 4, pp. 487-496. https://doi.org/10.3390/neurolint13040048