From Low-Grade Inflammation in Osteoarthritis to Neuropsychiatric Sequelae : A Narrative Review
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Date
2022-12-16
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Abstract
Nowadays, osteoarthritis (OA), a common, multifactorial musculoskeletal disease, is considered to have a low-grade inflammatory pathogenetic component. Lately, neuropsychiatric sequelae of the disease have gained recognition. However, a link between the peripheral inflammatory process of OA and the development of neuropsychiatric pathology is not completely understood. In this review, we provide a narrative that explores the development of neuropsychiatric disease in the presence of chronic peripheral low-grade inflammation with a focus on its signaling to the brain. We describe the development of a pro-inflammatory environment in the OA-affected joint. We discuss inflammation-signaling pathways that link the affected joint to the central nervous system, mainly using primary sensory afferents and blood circulation via circumventricular organs and cerebral endothelium. The review describes molecular and cellular changes in the brain, recognized in the presence of chronic peripheral inflammation. In addition, changes in the volume of gray matter and alterations of connectivity important for the assessment of the efficacy of treatment in OA are discussed in the given review. Finally, the narrative considers the importance of the use of neuropsychiatric diagnostic tools for a disease with an inflammatory component in the clinical setting.
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Funding Information: This study was supported by Rīga Stradiņš University Internal Research Grant Nr. 6-ZD-22/3/2022, 2022 Fundamental and Applied Research Project Nr. Izp-2022/1-0045 “Identification of specific osteoarthritis phenotypes and disease endotypes tackled using the molecular and cellular assessment of the synovium-cartilage-bone interplay by correlation-based network analysis”. The article processing charge was covered by Rīga Stradiņš University Research Department. Publisher Copyright: © 2022 by the authors.
Keywords
osteoarthritis, low-grade inflammation, cytokines, signaling, central nervous system, neuropsychiatric disease, 3.1 Basic medicine, 3.2 Clinical medicine, 1.1. Scientific article indexed in Web of Science and/or Scopus database
Citation
Naumovs, V, Groma, V & Mednieks, J 2022, 'From Low-Grade Inflammation in Osteoarthritis to Neuropsychiatric Sequelae : A Narrative Review', International Journal of Molecular Sciences, vol. 23, no. 24, 16031. https://doi.org/10.3390/ijms232416031