Effect of Human Herpesviruses 6 and 7 Infection on the Clinical Course of Rheumatoid Arthritis

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dc.contributor.authorKadiša, Anda
dc.contributor.authorNora-Krūkle, Zaiga
dc.contributor.authorKozireva, Svetlana
dc.contributor.authorSvirskis, Simons
dc.contributor.authorStuders, Peteris
dc.contributor.authorGroma, Valerija
dc.contributor.authorLejnieks, Aivars
dc.contributor.authorMurovska, Modra
dc.contributor.institutionDepartment of Internal Diseases
dc.contributor.institutionInstitute of Microbiology and Virology
dc.contributor.institutionJoint Laboratory of Traumatology and Orthopaedics
dc.contributor.institutionInstitute of Anatomy and Anthropology
dc.date.accessioned2021-04-20T13:00:01Z
dc.date.available2021-04-20T13:00:01Z
dc.date.issued2016-08-01
dc.descriptionPublisher Copyright: © 2016 by Anda Kadiša. Copyright: Copyright 2018 Elsevier B.V., All rights reserved.
dc.description.abstractRheumatoid arthritis (RA) is a chronic systemic autoimmune inflammatory disease affecting joints and causing symmetrical chronic progressive aseptic synovitis and erosive-destructive changes. Viruses and viral infections are considered to be the main risk factors for autoimmune disease development (especially for individuals with genetic predisposition). The goal of this study was to evaluate the frequency of HHV-6 and HHV-7 persistent infection and its activity phase in RA and osteoarthritis (OA) patients, and healthy persons. We examined also the influence of HHV-6 and-7 infections on RA activity, aggressiveness, radiographical stage, and frequency of complications as well as the presence of HHV-6 infection markers in synovial fluid and synovial tissues of RA joints of affected patients. Despite the lack of significant correlation between frequency of persistent single HHV-6, single HHV-7, and concurrent HHV-6 and HHV-7 infection and RA clinical course, we found that both active and latent HHV-6 and/or HHV-7 infection increased RA activity and progression in several clinical and laboratory parameters. Regarding the severity of the course of RA, we observed also a high prevalence of RA complications in the patient group with active single HHV-6 infection and also a more severe radiographical stage in RA patients with active concurrent HHV-6 and HHV-7 infection. Moreover, viral infection markers were found in synovial fluid and synovial tissues of affected joints of RA patients. This suggests that HHV-6 and/or HHV-7 infection has effect on the disease clinical course, but virus reactivation may be a consequence of immunosuppressive treatment.en
dc.description.statusPeer reviewed
dc.format.extent10
dc.format.extent850383
dc.identifier.citationKadiša, A, Nora-Krūkle, Z, Kozireva, S, Svirskis, S, Studers, P, Groma, V, Lejnieks, A & Murovska, M 2016, 'Effect of Human Herpesviruses 6 and 7 Infection on the Clinical Course of Rheumatoid Arthritis', Proceedings of the Latvian Academy of Sciences, Section B: Natural, Exact, and Applied Sciences, vol. 70, no. 4, pp. 165-174. https://doi.org/10.1515/prolas-2016-0028
dc.identifier.doi10.1515/prolas-2016-0028
dc.identifier.issn1407-009X
dc.identifier.urihttps://dspace.rsu.lv/jspui/handle/123456789/3866
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=84983443166&partnerID=8YFLogxK
dc.language.isoeng
dc.relation.ispartofProceedings of the Latvian Academy of Sciences, Section B: Natural, Exact, and Applied Sciences
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectHHV-6
dc.subjectHHV-7
dc.subjectrheumatoid arthritis
dc.subjectviral reactivation
dc.subject3.3 Health sciences
dc.subject1.1. Scientific article indexed in Web of Science and/or Scopus database
dc.subjectGeneral
dc.titleEffect of Human Herpesviruses 6 and 7 Infection on the Clinical Course of Rheumatoid Arthritisen
dc.type/dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article

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