Human haematopoietic stem cell development : From the embryo to the dish

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dc.contributor.authorIvanovs, Andrejs
dc.contributor.authorRybtsov, Stanislav
dc.contributor.authorNg, Elizabeth S.
dc.contributor.authorStanley, Edouard G.
dc.contributor.authorElefanty, Andrew G.
dc.contributor.authorMedvinsky, Alexander
dc.date.accessioned2021-05-14T09:20:01Z
dc.date.available2021-05-14T09:20:01Z
dc.date.issued2017
dc.descriptionPublisher Copyright: © 2017. Published by The Company of Biologists Ltd.
dc.description.abstractHaematopoietic stem cells (HSCs) emerge during embryogenesis and give rise to the adult haematopoietic system. Understanding how early haematopoietic development occurs is of fundamental importance for basic biology and medical sciences, but our knowledge is still limited compared with what we know of adult HSCs and their microenvironment. This is particularly true for human haematopoiesis, and is reflected in our current inability to recapitulate the development of HSCs from pluripotent stem cells in vitro. In this Review, we discuss what is known of human haematopoietic development: the anatomical sites at which it occurs, the different temporal waves of haematopoiesis, the emergence of the first HSCs and the signalling landscape of the haematopoietic niche. We also discuss the extent to which in vitro differentiation of human pluripotent stem cells recapitulates bona fide human developmental haematopoiesis, and outline some future directions in the field.en
dc.description.statusPeer reviewed
dc.format.extent15
dc.format.extent4940451
dc.identifier.citationIvanovs, A, Rybtsov, S, Ng, E S, Stanley, E G, Elefanty, A G & Medvinsky, A 2017, 'Human haematopoietic stem cell development : From the embryo to the dish', Development (Cambridge), vol. 144, no. 13, pp. 2323-2337. https://doi.org/10.1242/dev.134866
dc.identifier.doi10.1242/dev.134866
dc.identifier.issn0950-1991
dc.identifier.urihttps://dspace.rsu.lv/jspui/handle/123456789/4245
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=85021730953&partnerID=8YFLogxK
dc.language.isoeng
dc.relation.ispartofDevelopment (Cambridge)
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectEmbryo
dc.subjectHPSC
dc.subjectHSC
dc.subjectHuman
dc.subjectReprogramming
dc.subject1.6 Biological sciences
dc.subject3.1 Basic medicine
dc.subject3.2 Clinical medicine
dc.subject1.1. Scientific article indexed in Web of Science and/or Scopus database
dc.subjectMolecular Biology
dc.subjectDevelopmental Biology
dc.subjectSDG 3 - Good Health and Well-being
dc.titleHuman haematopoietic stem cell development : From the embryo to the dishen
dc.type/dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/systematicreview

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