Phenolic Content and Anti-Inflammatory Activity of Cultivated and Wild-Type Galium odoratum Extracts in Murine Bone Marrow-Derived Macrophages

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dc.contributor.authorRazživina, Valērija
dc.contributor.authorVasiljeva, Anna
dc.contributor.authorKronberga, Arta
dc.contributor.authorSkudrins, Gundars
dc.contributor.authorNakurte, Ilva
dc.contributor.authorŽogota, Marta
dc.contributor.authorMezaka, Ieva
dc.contributor.authorPugovics, Osvalds
dc.contributor.authorGrinberga, Solveiga
dc.contributor.authorDambrova, Maija
dc.contributor.authorSīle, Inga
dc.contributor.institutionDepartment of Pharmaceutical Chemistry
dc.contributor.institutionLaboratory of Finished Dosage Forms
dc.contributor.institutionDepartment of Applied Pharmacy
dc.date.accessioned2024-12-06T08:25:01Z
dc.date.available2024-12-06T08:25:01Z
dc.date.issued2024-11-25
dc.descriptionPublisher Copyright: © 2024 by the authors.
dc.description.abstractGalium odoratum, commonly known as sweet woodruff, is a perennial herbaceous plant that contains coumarin and is recognized for its medicinal properties. In this study, the influence of sunlight exposure on the phytochemical composition and anti-inflammatory potential of G. odoratum extracts is assessed. The extracts from cultivated and wild-grown plants were analyzed via chromatographic and mass spectrometric methods. In addition, the total phenolic content, antioxidant activity, and effects on macrophage polarization were assessed. The results revealed that while coumarin levels remain stable regardless of environmental conditions, phenolic content and antioxidant activity increase significantly under sun-grown conditions, with chlorogenic acid and rutin identified as major contributing compounds. Additionally, the extracts exhibited anti-inflammatory activity, effectively reducing the M1 macrophage population involved in inflammatory responses. These findings suggest that controlled sunlight exposure can enhance the bioactive profile of G. odoratum. This research highlights the critical role of environmental management in optimizing the medicinal properties of G. odoratum, providing a foundation for its future use in natural therapeutic applications.en
dc.description.statusPeer reviewed
dc.format.extent1885367
dc.identifier.citationRazživina, V, Vasiljeva, A, Kronberga, A, Skudrins, G, Nakurte, I, Žogota, M, Mezaka, I, Pugovics, O, Grinberga, S, Dambrova, M & Sīle, I 2024, 'Phenolic Content and Anti-Inflammatory Activity of Cultivated and Wild-Type Galium odoratum Extracts in Murine Bone Marrow-Derived Macrophages', Antioxidants, vol. 13, no. 12, 1447. https://doi.org/10.3390/antiox13121447
dc.identifier.doi10.3390/antiox13121447
dc.identifier.issn2076-3921
dc.identifier.urihttps://dspace.rsu.lv/jspui/handle/123456789/16956
dc.identifier.urlhttps://www.mdpi.com/2076-3921/13/12/1447
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=85213240790&partnerID=8YFLogxK
dc.language.isoeng
dc.relation.ispartofAntioxidants
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectGalium odoratum
dc.subjectphytochemical composition
dc.subjectcoumarin
dc.subjectLC-MS analysis
dc.subjectessential oils
dc.subjectGC-MS analysis
dc.subjectpro-inflammatory activity
dc.subject3.1 Basic medicine
dc.subject1.1. Scientific article indexed in Web of Science and/or Scopus database
dc.subjectGeneral Chemistry
dc.titlePhenolic Content and Anti-Inflammatory Activity of Cultivated and Wild-Type Galium odoratum Extracts in Murine Bone Marrow-Derived Macrophagesen
dc.type/dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article

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