Accuracy of 68Ga-PSMA-11 PET/CT and multiparametric MRI for the detection of local tumor and lymph node metastases in early biochemical recurrence of prostate cancer

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dc.contributor.authorRadzina, Maija
dc.contributor.authorTirane, Mara
dc.contributor.authorRoznere, Lilita
dc.contributor.authorZemniece, Liene
dc.contributor.authorDronka, Laura
dc.contributor.authorKalnina, Marika
dc.contributor.authorMamis, Edgars
dc.contributor.authorBiederer, Juergen
dc.contributor.authorLietuvietis, Vilnis
dc.contributor.authorFreimanis, Arvis
dc.contributor.authorVjaters, Egils
dc.contributor.institutionDepartment of Radiology
dc.date.accessioned2023-12-05T12:20:01Z
dc.date.available2023-12-05T12:20:01Z
dc.date.issued2020
dc.descriptionAJNMMI Copyright © 2020.
dc.description.abstractAnatomical and functional imaging plays a decisive role for detection and staging, of prostate cancer both primarily and post-treatment. While multiparametric MRI offers anatomic imaging with excellent soft tissue contrast, hybrid imaging based on positron emission tomography in combination with computed tomography (PET/CT) contributes functional imaging capacities. Since 68Ga-PSMA-11 was expected to be more efficient than the prior Choline-based PET radiotracers, it was the aim of the study to evaluate the diagnostic performance of the 68Ga-PSMA-11 PET/CT and multiparametric MRI in patients with recurrent prostate cancer and low PSA levels. 32 out of a cohort of 128 prostate cancer patients with biochemical relapse were referred for 68Ga-PSMA-11 PET/CT, MRI and bone scintigraphy. According to the histopathologically or clinically defined reference standard all results were classified as true positive, false positive, true negative or false negative. Local recurrence was present in 11/32 patients, lymph node metastases - in 13/32 patients and, bone metastases - in 6/32 patients. Against the standard of reference, sensitivity, specificity and accuracy for local recurrence of PET/CT were 63.6 %; 73.7%; 77.8%, respectively. MRI reached 90.9%; 94.7%; 92.3%, respectively. For local lymph node metastases PET/CT - 83.3%; 80.0% and 90.6%, respectively. MRI - 41.7%; 94.4%; 72.0%, respectively. For evaluation of bone metastases in PET/CT - 83.3%; 92.0%; 71.0%, respectively. Bone scintigraphy - 50.0%; 84.0%; 77.4%, respectively. In conclusion, mpMRI offered the better diagnostic accuracy in the detection of local recurrence and while PSMA PET/CT was superior in the detection of distant and lymph node metastases.en
dc.description.statusPeer reviewed
dc.format.extent13
dc.format.extent800693
dc.identifier.citationRadzina, M, Tirane, M, Roznere, L, Zemniece, L, Dronka, L, Kalnina, M, Mamis, E, Biederer, J, Lietuvietis, V, Freimanis, A & Vjaters, E 2020, 'Accuracy of 68Ga-PSMA-11 PET/CT and multiparametric MRI for the detection of local tumor and lymph node metastases in early biochemical recurrence of prostate cancer', American journal of nuclear medicine and molecular imaging, vol. 10, no. 2, pp. 106-118.
dc.identifier.issn2160-8407
dc.identifier.otherPubMedCentral: PMC7218697
dc.identifier.urihttps://dspace.rsu.lv/jspui/handle/123456789/15029
dc.identifier.urlhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7218697/pdf/ajnmmi0010-0106.pdf
dc.language.isoeng
dc.relation.ispartofAmerican journal of nuclear medicine and molecular imaging
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectPSMA-PET/CT
dc.subjectMRI
dc.subjectprostate cancer
dc.subjectrecurrence
dc.subjectrestaging
dc.subject68Ga-PSMA
dc.subject3.2 Clinical medicine
dc.subject1.1. Scientific article indexed in Web of Science and/or Scopus database
dc.subjectSDG 3 - Good Health and Well-being
dc.titleAccuracy of 68Ga-PSMA-11 PET/CT and multiparametric MRI for the detection of local tumor and lymph node metastases in early biochemical recurrence of prostate canceren
dc.type/dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article

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