Plasma acylcarnitine concentrations reflect the acylcarnitine profile in cardiac tissues

Simple item page
dc.contributor.authorMakrecka-Kuka, Marina
dc.contributor.authorSevostjanovs, Eduards
dc.contributor.authorVilks, Karlis
dc.contributor.authorVolska, Kristine
dc.contributor.authorAntone, Unigunde
dc.contributor.authorKuka, Janis
dc.contributor.authorMakarova, Elina
dc.contributor.authorPugovics, Osvalds
dc.contributor.authorDambrova, Maija
dc.contributor.authorLiepinsh, Edgars
dc.contributor.institutionFaculty of Pharmacy
dc.date.accessioned2021-04-28T11:25:01Z
dc.date.available2021-04-28T11:25:01Z
dc.date.issued2017-12-01
dc.descriptionFunding Information: This study was supported by the Latvian National Research Program BIOMEDICINE. E. Liepinsh was supported by the FP7 project InnovaBalt [grant Nr. 316149]. We would like to thank Dr. Reinis Vilskersts and Gita Dambrova for help with the isolated skeletal muscle experiments. Publisher Copyright: © 2017 The Author(s).
dc.description.abstractIncreased plasma concentrations of acylcarnitines (ACs) are suggested as a marker of metabolism disorders. The aim of the present study was to clarify which tissues are responsible for changes in the AC pool in plasma. The concentrations of medium- and long-chain ACs were changing during the fed-fast cycle in rat heart, muscles and liver. After 60 min running exercise, AC content was increased in fasted mice muscles, but not in plasma or heart. After glucose bolus administration in fasted rats, the AC concentrations in plasma decreased after 30 min but then began to increase, while in the muscles and liver, the contents of medium- and long-chain ACs were unchanged or even increased. Only the heart showed a decrease in medium- and long-chain AC contents that was similar to that observed in plasma. In isolated rat heart, but not isolated-contracting mice muscles, the significant efflux of medium- and long-chain ACs was observed. The efflux was reduced by 40% after the addition of glucose and insulin to the perfusion solution. Overall, these results indicate that during fed-fast cycle shifting the heart determines the medium- and long-chain AC profile in plasma, due to a rapid response to the availability of circulating energy substrates.en
dc.description.statusPeer reviewed
dc.format.extent1410308
dc.identifier.citationMakrecka-Kuka, M, Sevostjanovs, E, Vilks, K, Volska, K, Antone, U, Kuka, J, Makarova, E, Pugovics, O, Dambrova, M & Liepinsh, E 2017, 'Plasma acylcarnitine concentrations reflect the acylcarnitine profile in cardiac tissues', Scientific Reports, vol. 7, no. 1, 17528. https://doi.org/10.1038/s41598-017-17797-x
dc.identifier.doi10.1038/s41598-017-17797-x
dc.identifier.issn2045-2322
dc.identifier.urihttps://dspace.rsu.lv/jspui/handle/123456789/3974
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=85038414985&partnerID=8YFLogxK
dc.language.isoeng
dc.relation.ispartofScientific Reports
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subject3.1 Basic medicine
dc.subject1.1. Scientific article indexed in Web of Science and/or Scopus database
dc.subjectGeneral
dc.titlePlasma acylcarnitine concentrations reflect the acylcarnitine profile in cardiac tissuesen
dc.type/dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article

Files

Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
Plasma_acylcarnitine.pdf
Size:
1.34 MB
Format:
Adobe Portable Document Format
Download

Collections

Research outputs from Pure / Zinātniskās darbības rezultāti no ZDIS Pure