Ķīmijterapijas toksicitātes ietekme uz pacientiem vecuma grupā virs 80 gadu vecuma
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Date
2023
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Rīgas Stradiņa universitāte
Rīga Stradiņš University
Rīga Stradiņš University
Abstract
Latvijas sabiedrības novecošanās tendence ir līdzvērtīga Eiropā novērotajai, pieaug populācijas daļa, kura sasniegusi vecumu virs 80 gadiem. Retrospektīvā pētījumā analizēta ķīmijterapijas toksicitātes ietekme uz pacientiem vecuma grupā virs 80 gadu vecuma, kas terapiju saņēmuši Rīgas Austrumu klīniskās universitātes slimnīcas, Latvijas Onkoloģias centra 9A ķīmijterapijas nodaļā laika periodā no 01.01.2021. līdz 31.12.2022.
Pētījumā iekļauti 24 pacienti no 204, kuri atbilst iekļaušanas kritērijiem. Apkopojot datus, rezultāti par ķīmijterapijas tokcisitātes ietekmi uz pacientiem, nehematoloģiski efekti, kas vērtējami kā 3- 4 pakāpes (Grade 3- 4), pacientus skar biežāk 63,29%, nekā tāda paša līmeņa hematoloģiskie efekti. Daļā gadījumu, terapijas iespējamā toksicitāte ir paredzama pirms uzsākta terapija, plānotā ķīmijpreparāta dēļ. Rezultāti ļauj secināt, ka smagas pakāpes (grade-4-5) ķīmijterapijas toksicitāte sastopama < 36,7% un nav iemesls terapijas pārtraukšanai.
The aging trend of Latvian society is equivalent to that observed in Europe, i.e. the population size that has reached the age of over 80 is increasing. This retrospective study analyzes the effect of chemotherapy toxicity in patients in the age group of over 80 years of age, who received therapy at Riga East University Hospital, Latvian Oncology Center, 9A chemotherapy department in the period from 01.01.2021. until 31.12.2022. Out of 204 patients, 24 met the inclusion criteria and were used for the study. After summarizing data, the results estimated as Grade 3-4 of the effects in chemotherapy toxicity on patients, nonhematological effects, affect more often 63,29%, than hematological effects of the same level. In some cases, the possible toxicity of the therapy can be forseen before the start of therapy due to the planned chemotherapy medicine. From the results we can conclude that the toxicity of severe grade (Grade4-5) in chemotherapy toxicity occurs in < 36,7% and should not be a reason to stop therapy.
The aging trend of Latvian society is equivalent to that observed in Europe, i.e. the population size that has reached the age of over 80 is increasing. This retrospective study analyzes the effect of chemotherapy toxicity in patients in the age group of over 80 years of age, who received therapy at Riga East University Hospital, Latvian Oncology Center, 9A chemotherapy department in the period from 01.01.2021. until 31.12.2022. Out of 204 patients, 24 met the inclusion criteria and were used for the study. After summarizing data, the results estimated as Grade 3-4 of the effects in chemotherapy toxicity on patients, nonhematological effects, affect more often 63,29%, than hematological effects of the same level. In some cases, the possible toxicity of the therapy can be forseen before the start of therapy due to the planned chemotherapy medicine. From the results we can conclude that the toxicity of severe grade (Grade4-5) in chemotherapy toxicity occurs in < 36,7% and should not be a reason to stop therapy.
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Geriatrs
Geriatrician
Geriatrician
Keywords
Chemotherapy, ECOG, hematologic, nonhematologic, Karnofsky Performance Status, toxicity, ECOG skala, Karnofska fiziskās aktivitātes statuss, ķīmijterapija, hematoloģiska, nehematoloģiska, toksicitāte