Ectopic Adipose Tissue Storage in the Left and the Right Renal Sinus is Asymmetric and Associated With Serum Kidney Injury Molecule-1 and Fibroblast Growth Factor-21 Levels Increase
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Date
2016-11-01
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Abstract
Objective A potential mechanism by which obesity could promote hypertension and kidney diseases is through accumulation of adipose tissue in the renal sinus (RS). The aim of the study was to quantify RS and abdominal adipose tissue volumes and to evaluate serum kidney injury molecule (sKIM)-1 and fibroblast growth factor (FGF)-21 association with different adipose tissue compartments. Methods The cross-sectional study included 280 and follow-up study-40 asymptomatic participants; aged 38.30 ± 4.10. For all study participants computed tomography examination was performed, sKIM-1 and FGF-21 levels were measured. Results The results indicated asymmetrical deposition of adipose tissue into the RS even after corresponding kidney volume adjustment. The cross-sectional and the follow-up studies showed that sKIM-1 level was positively associated with RS adipose tissue volume increase for both genders. FGF-21 was positively associated with RS and retroperitoneal adipose tissue amount. Conclusions Regardless of gender adipose tissue in RS accumulates asymmetrically–the left RS accumulates a significantly higher amount of adipose tissue. Thus, primarily RS adipose tissue effects should be assessed on the left kidney. Accumulation of adipose tissue in the RS is related with the visceral adipose amount, KIM-1 and FGF-21 concentration increase in the blood serum.
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Funding Information: Research relating to this abstract were funded by the European Social Fund within the project “Innovative technologies for acquisition and processing of biomedical images” No. 2013/0009/1DP/1.1.1.2.0/13/APIA/VIAA/014 , European Social Fund within the project “Support for Doctoral Studies at University of Latvia”, and by the grant No. 2014.10-4/VPP-5/16 BIOMEDICINE of the framework of the Latvian National Program. These funding sources had no role in the study design; collection, analysis and interpretation of data; writing of the manuscript; and decision to submit the manuscript for publication. Publisher Copyright: © 2016 The Authors
Keywords
Asymmetry, FGF-21, KIM-1, Obesity, Renal sinus, Visceral adipose tissue, 3.1 Basic medicine, 1.1. Scientific article indexed in Web of Science and/or Scopus database, General Biochemistry,Genetics and Molecular Biology, SDG 3 - Good Health and Well-being
Citation
Krievina, G, Tretjakovs, P, Skuja, I, Silina, V, Keisa, L, Krievina, D & Bahs, G 2016, 'Ectopic Adipose Tissue Storage in the Left and the Right Renal Sinus is Asymmetric and Associated With Serum Kidney Injury Molecule-1 and Fibroblast Growth Factor-21 Levels Increase', EBioMedicine, vol. 13, pp. 274-283. https://doi.org/10.1016/j.ebiom.2016.10.020