Reproducibility and predictive value of scoring stromal tumour infiltrating lymphocytes in triple-negative breast cancer : a multi-institutional study

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dc.contributor.authorO’Loughlin, Mark
dc.contributor.authorAndreu, Xavier
dc.contributor.authorBianchi, Simonetta
dc.contributor.authorChemielik, Ewa
dc.contributor.authorCordoba, Alicia
dc.contributor.authorCserni, Gábor
dc.contributor.authorFigueiredo, Paulo
dc.contributor.authorFloris, Giuseppe
dc.contributor.authorFoschini, Maria P.
dc.contributor.authorHeikkilä, Päivi
dc.contributor.authorKulka, Janina
dc.contributor.authorLiepniece-Karele, Inta
dc.contributor.authorRegitnig, Peter
dc.contributor.authorReiner, Angelika
dc.contributor.authorRyska, Ales
dc.contributor.authorSapino, Anna
dc.contributor.authorShalaby, Aliaa
dc.contributor.authorStovgaard, Elisabeth Specht
dc.contributor.authorQuinn, Cecily
dc.contributor.authorWalsh, Elaine M.
dc.contributor.authorZolota, Vicky
dc.contributor.authorGlynn, Sharon A.
dc.contributor.authorCallagy, Grace
dc.date.accessioned2021-12-13T09:25:01Z
dc.date.available2021-12-13T09:25:01Z
dc.date.issued2018-08-01
dc.descriptionFunding Information: Funding This work was funded by Breast Cancer Now (2013MayPR019 and 2015NovPhD643), Science Foundation Ireland (17/CDA/4638) and Irish Cancer Society (SG); Breast Cancer Research (EW), and an NUI Galway School of Medicine Scholarship (EW). Publisher Copyright: © 2018, The Author(s).
dc.description.abstractBackground: Several studies have demonstrated a prognostic role for stromal tumour infiltrating lymphocytes (sTILs) in triple-negative breast cancer (TNBC). The reproducibility of scoring sTILs is variable with potentially excellent concordance being achievable using a software tool. We examined agreement between breast pathologists across Europe scoring sTILs on H&E-stained sections without software, an approach that is easily applied in clinical practice. The association between sTILs and response to anthracycline-taxane NACT was also examined. Methodology: Pathologists from the European Working Group for Breast Screening Pathology scored sTILs in 84 slides from 75 TNBCs using the immune-oncology biomarker working group guidance in two circulations. There were 16 participants in the first and 19 in the second circulation. Results: Moderate agreement was achieved for absolute sTILs scores (intraclass correlation coefficient (ICC) = 0.683, 95% CI 0.601–0.767, p-value < 0.001). Agreement was less when a 25% threshold was used (ICC 0.509, 95% CI 0.416–0.614, p-value < 0.001) and for lymphocyte predominant breast cancer (LPBC) (ICC 0.504, 95% CI 0.412–0.610, p-value < 0.001). Intra-observer agreement was strong for absolute sTIL values (Spearman ρ = 0.727); fair for sTILs ≥ 25% (κ = 0.53) and for LPBC (κ = 0.49), but poor for sTILs as 10% increments (κ = 0.24). Increasing sTILs was significantly associated with an increased likelihood of a pathological complete response (pCR) on multivariable analysis. Conclusion: Increasing sTILs in TNBCs improves the likelihood of a pCR. However, inter-observer agreement is such that H&E-based assessment is not sufficiently reproducible for clinical application. Other methodologies should be explored, but may be at the cost of ease of application.en
dc.format.extent9
dc.format.extent2011343
dc.identifier.citationO’Loughlin, M, Andreu, X, Bianchi, S, Chemielik, E, Cordoba, A, Cserni, G, Figueiredo, P, Floris, G, Foschini, M P, Heikkilä, P, Kulka, J, Liepniece-Karele, I, Regitnig, P, Reiner, A, Ryska, A, Sapino, A, Shalaby, A, Stovgaard, E S, Quinn, C, Walsh, E M, Zolota, V, Glynn, S A & Callagy, G 2018, 'Reproducibility and predictive value of scoring stromal tumour infiltrating lymphocytes in triple-negative breast cancer : a multi-institutional study', Breast Cancer Research and Treatment, vol. 171, no. 1, pp. 1-9. https://doi.org/10.1007/s10549-018-4825-8
dc.identifier.doi10.1007/s10549-018-4825-8
dc.identifier.issn0167-6806
dc.identifier.urihttps://dspace.rsu.lv/jspui/handle/123456789/7031
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=85047135321&partnerID=8YFLogxK
dc.language.isoeng
dc.relation.ispartofBreast Cancer Research and Treatment
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectInter-observer agreement
dc.subjectNeoadjuvant chemotherapy
dc.subjectPathological complete response
dc.subjectsTILs
dc.subjectStromal tumour infiltrating lymphocytes
dc.subjectTriple-negative breast cancer
dc.subject3.1 Basic medicine
dc.subject3.2 Clinical medicine
dc.subject1.1. Scientific article indexed in Web of Science and/or Scopus database
dc.subjectOncology
dc.subjectCancer Research
dc.subjectSDG 3 - Good Health and Well-being
dc.titleReproducibility and predictive value of scoring stromal tumour infiltrating lymphocytes in triple-negative breast cancer : a multi-institutional studyen
dc.type/dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/editorial

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