Lack of association between polymorphisms in genes MTHFR and MDR1 with risk of childhood acute lymphoblastic leukemia
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Date
2014
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Abstract
Background: Acute lymphoblastic leukemia (ALL) is a complex disease caused by interactions between hazardous exogenous or/and endogenous agents and many mild effect inherited susceptibility mutations. Some of them are known, but their functional roles still requireinvestigation. Age is a recognized risk factor; children with disease onset after the age of ten have worse prognosis, presumably also triggered by inherited factors. Materials and Methods: The MDR1 gene polymorphisms rs1045642, rs2032582 and MTHFR gene polymorphisms rs1801131 and rs1801133 were genotyped in 68 ALL patients in remission and 102 age and gender matched controls; parental DNA samples were also available for 42 probands. Results: No case control association was found between analyzed polymorphisms and a risk of childhood ALL development. Linkage disequilibrium was not observed in a family-based association study either. Only marginal association was observed between genetic marker rs2032582A and later disease onset (p=0.04). Conclusions: Our data suggest that late age of ALL onset could be triggered by mild effect common alleles.
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Keywords
Childhood cases, Lymphoblastic leukemia, MDR1, MTHFR, Polymorphisms, 3.2 Clinical medicine, 3.3 Health sciences, 1.1. Scientific article indexed in Web of Science and/or Scopus database, Epidemiology, Oncology, Public Health, Environmental and Occupational Health, Cancer Research, SDG 3 - Good Health and Well-being
Citation
Kreile, M, Rots, D, Piekuse, L, Cebura, E, Grutupa, M, Kovalova, Z & Lace, B 2014, 'Lack of association between polymorphisms in genes MTHFR and MDR1 with risk of childhood acute lymphoblastic leukemia', Asian Pacific Journal of Cancer Prevention, vol. 15, no. 22, pp. 9707-9711. https://doi.org/10.7314/APJCP.2014.15.22.9707