Large Parathyroid Tumor 8 Years after Thyroid Surgery : A Case Report

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dc.contributor.authorRatniece, Madara
dc.contributor.authorTauvena, Elina
dc.contributor.authorPavlovics, Sergejs
dc.contributor.authorNiciporuka, Rita
dc.contributor.authorLiepa, Mara
dc.contributor.authorPrieditis, Peteris
dc.contributor.authorOzolins, Arturs
dc.contributor.authorGardovskis, Janis
dc.contributor.authorRadzina, Maija
dc.contributor.authorNarbuts, Zenons
dc.contributor.institutionDepartment of Radiology
dc.contributor.institutionFaculty of Medicine
dc.contributor.institutionDepartment of Surgery
dc.date.accessioned2022-08-16T21:03:15Z
dc.date.available2022-08-16T21:03:15Z
dc.date.issued2022-05-16
dc.descriptionFunding Information: This case report was funded by the Fundamental and Useful Research Project (FLPP) within the project “Multiparametric ultrasound correlation with morphology in patients with primary hyperparathyroidism [Nr. lzp-2020/2-0297].” The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Publisher Copyright: © 2022 S. Karger AG. All rights reserved.
dc.description.abstractThis report represents an unusually large parathyroid carcinoma (PC) mimicking thyroid nodule recurrence after hemithyroidectomy. PC is a rare endocrine malignancy accounting for less than 1% of hyperparathyroidism cases. This is the first case report where contrast-enhanced ultrasound (CEUS) was performed on a PC. A 63-year-old female presented with an enlarged mass on the left side of the neck. In 2012, left-side hemithyroidectomy was done due to a benign goiter. In 2020, laboratory analysis showed markedly elevated parathyroid hormone and calcium. Multiparametric neck ultrasonography was performed including B-mode, color Doppler, shear wave elastography, and CEUS. Computed tomography revealed an irregular mass in proximity to the trachea, esophagus, and dislocation of the common carotid artery. Perifocal fatty tissue appeared normal. Scintigraphy displayed a suspected parathyroid tumor or a suspected left lobe nodule of thyroid. Based on the biochemical diagnosis of primary hyperparathyroidism and radiological examinations, a suspected parathyroid tumor was considered. Intraoperative findings demonstrated an unusually large 9 × 6 cm tumor (84 g) adjacent to the common carotid artery anterolaterally and the recurrent laryngeal nerve medially. Pathohistological examination revealed a tumor solid in structure, with focal necrosis penetrating the capsule. Immunohistochemical analysis was positive for chromogranin, CD56, and Ki-67 (8–10%) and negative for CK20 and CK7. The morphological and immunohistochemical results correspond to PC. PC is a challenging diagnosis requiring a multidisciplinary approach, especially in the case of previous neck surgery. The only curative treatment for PC is radical surgery. Lifelong monitoring of PCs is mandatory due to the high recurrence rate.en
dc.description.statusPeer reviewed
dc.format.extent7
dc.format.extent1139772
dc.identifier.citationRatniece, M, Tauvena, E, Pavlovics, S, Niciporuka, R, Liepa, M, Prieditis, P, Ozolins, A, Gardovskis, J, Radzina, M & Narbuts, Z 2022, 'Large Parathyroid Tumor 8 Years after Thyroid Surgery : A Case Report', Case Reports in Oncology, vol. 15, no. 2, pp. 528-534. https://doi.org/10.1159/000524070
dc.identifier.doi10.1159/000524070
dc.identifier.issn1662-6575
dc.identifier.othercrossref: 10.1159/000524070
dc.identifier.otherMendeley: c3e90330-6915-3aae-931c-35fb3e272dd1
dc.identifier.urihttps://dspace.rsu.lv/jspui/handle/123456789/9423
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=85139934455&partnerID=8YFLogxK
dc.language.isoeng
dc.relation.ispartofCase Reports in Oncology
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectParathyroid surgery
dc.subjectParathyroid carcinoma
dc.subjectHyperparathyroidism
dc.subjectParathyroid hormone
dc.subjectContrast-enhanced ultrasound
dc.subject3.2 Clinical medicine
dc.subject1.1. Scientific article indexed in Web of Science and/or Scopus database
dc.subjectOncology
dc.titleLarge Parathyroid Tumor 8 Years after Thyroid Surgery : A Case Reporten
dc.type/dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article

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