Maximal Fat Oxidation Rate Is Higher in Fit Women and Unfit Women with Obesity, Compared to Normal-weight Unfit Women
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Date
2021-11-01
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Abstract
Context: The maximal fat oxidation rate (MFO) is higher in aerobically fit vs unfit young men, but this training-related increase in MFO is attenuated in middle-aged men. Further, it has also been found that unfit men with obesity may have an elevated MFO compared to unfit normal-weight men. Objective: Based hereupon, we aimed to investigate whether a fitness-related higher MFO were attenuated in middle-aged women compared to young women. Also, we aimed to investigate if unfit women with obesity have a higher MFO compared to unfit normal-weight women. We hypothesized that the training-related elevated MFO was attenuated in middle-aged women, but that unfit women with obesity would have an elevated MFO compared to unfit normal-weight women. Methods: We recruited 70 women stratified into 6 groups: young fit (n = 12), young unfit (n = 12) middle-aged fit (n = 12), middle-aged unfit (n = 12), unfit young women with obesity (n = 12), and unfit middle-aged women with obesity (n = 10). Body composition and resting blood samples were obtained and MFO was measured by a graded exercise test on a cycle ergometer via indirect calorimetry. Subsequently, a maximal exercise test was performed to establish peak oxygen uptake (V˙O2peak). Results: Young and middle-aged fit women had a higher MFO compared to age-matched unfit women, and young fit women had a higher MFO compared to fit middle-aged women. Unfit women with obesity, independent of age, had a higher MFO compared to their normal-weight and unfit counterparts. Conclusion: The training-related increase in MFO seems maintained in middle-aged women, and we find that unfit women with obesity, independent of age, have a higher MFO compared to unfit normal-weight women.
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Publisher Copyright: © 2021 The Author(s). Published by Oxford University Press on behalf of the Endocrine Society. All rights reserved.
Keywords
aging, fat oxidation, obesity, women, 3.1 Basic medicine, 1.1. Scientific article indexed in Web of Science and/or Scopus database, Endocrinology, Diabetes and Metabolism, Biochemistry, Endocrinology, Clinical Biochemistry, Biochemistry, medical, SDG 3 - Good Health and Well-being
Citation
Frandsen, J, Hansen, I M D, Wismann, J F, Olsen, M H, Brage-Andersen, M R, Sahl, R E, Hansen, M, Ingersen, A, Modvig, J L, Schmücker, M, Grauslund, C H, Dela, F, Larsen, S & Helge, J W 2021, 'Maximal Fat Oxidation Rate Is Higher in Fit Women and Unfit Women with Obesity, Compared to Normal-weight Unfit Women', Journal of Clinical Endocrinology and Metabolism, vol. 106, no. 11, pp. E4389-E4399. https://doi.org/10.1210/clinem/dgab473