HLA B27 allele types in homogeneous groups of juvenile idiopathic arthritis patients in Latvia

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dc.contributor.authorStanevicha, Valda
dc.contributor.authorEglite, Jelena
dc.contributor.authorZavadska, Dace
dc.contributor.authorSochnevs, Arturs
dc.contributor.authorLazareva, Arina
dc.contributor.authorGuseinova, Dinara
dc.contributor.authorShantere, Ruta
dc.contributor.authorGardovska, Dace
dc.contributor.institutionDepartment of Paediatrics
dc.contributor.institutionKlīniskās imunoloģijas un imunoģenētikas starpkatedru laboratorija
dc.date.accessioned2021-04-22T12:15:01Z
dc.date.available2021-04-22T12:15:01Z
dc.date.issued2010-10-14
dc.descriptionCopyright: Copyright 2010 Elsevier B.V., All rights reserved.
dc.description.abstractObjective: to investigate HLA B27 positive JIA patients clinical characteristics, determined HLA B27 allele types and their connection with antirheumatic treatment in homogenous patient groups.Materials and methods: 56 patients diagnosed with JIA and observed over the period 2006 to 2009 included in the study. HLAB27 allele types were determined using PCR method.Results: In HLA B27 positive JIA patients mean disease onset was 12.34 ± 3.3 years. Most common (44%) JIA type was enthesitis related arthritis. Positive response to the treatment with SS was found in 32% of patients, Methotrexate (MTX) - in 43%, combined treatment - SS with MTX was effective in 12.5%. 12.5% of patients required combination MTX with Enbrel.Eight HLA B27 allele types were found in JIA patients in Latvia: *2702, *2703, *2704, *2705, *2710, *2715, *2717, *2728. The most common was *2705 - in 55% of cases. Among all the patients enthesitis related arthritis most commonly occurred in patients with HLAB*2705 allele (OR = 2.01, p < 0.02), oligoarthritis in patients with *2710 allele (OR = 3.0, p < 0.04) and polyarthritis with *2717 allele (OR = 3.0, p < 0.05). In patients with *2705 allele effective treatment was MTX (OR = 1.13, p < 0.03) and MTX with SS (OR = 2.02, p < 0.05), but in patients having *2703 allele - MTX with Enbrel (OR = 2.94, p < 0.02).Conclusions: There are 8 different HLA B27 alleles in JIA patients in Latvia and the most common is *2705, but in order to assert them to be disease associated alleles, more extensive studies are needed, including control group of HLA B27 positive healthy individuals. Standard treatment approach with SS proves to be unsatisfactory in the majority of JIA patients. To improve children's quality of life achieving rapid disease control, the first line treatment in HLA B27 positive patients should be MTX. In order to start with the most appropriate drug it is necessary to determine HLAB 27 type at the onset of disease.en
dc.description.statusPeer reviewed
dc.format.extent365856
dc.identifier.citationStanevicha, V, Eglite, J, Zavadska, D, Sochnevs, A, Lazareva, A, Guseinova, D, Shantere, R & Gardovska, D 2010, 'HLA B27 allele types in homogeneous groups of juvenile idiopathic arthritis patients in Latvia', Pediatric Rheumatology, vol. 8, 26. https://doi.org/10.1186/1546-0096-8-26
dc.identifier.doi10.1186/1546-0096-8-26
dc.identifier.issn1546-0096
dc.identifier.urihttps://dspace.rsu.lv/jspui/handle/123456789/3902
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=77957779897&partnerID=8YFLogxK
dc.language.isoeng
dc.relation.ispartofPediatric Rheumatology
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subject3.2 Clinical medicine
dc.subject3.3 Health sciences
dc.subject1.1. Scientific article indexed in Web of Science and/or Scopus database
dc.subjectPediatrics, Perinatology, and Child Health
dc.subjectRheumatology
dc.subjectImmunology and Allergy
dc.titleHLA B27 allele types in homogeneous groups of juvenile idiopathic arthritis patients in Latviaen
dc.type/dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article

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