Renal Survival and Validation of Novel International Immunoglobulin A Nephropathy Prediction Tool in Latvian Population: Preliminary Data
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Date
2021-10
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Abstract
The aim of the study was to determine kidney survival and validate the novel international immunoglobulin A nephropathy (IgAN) prediction tool (PT) in the Latvian population. Adults with morphologically confirmed IgAN were included. Kidney survival was analysed with the Kaplan–Meier method. PT-assigned risk was compared with calculated risk by the Cox regression model. The Kaplan–Meier analysis included 95 patients. The five-year kidney survival Q3 was 24 months. Women had longer median kidney-survival time (> 60 months) than men (58 months). Median kidney survival in participants with MEST T0 was longer than 60 months; T1 and T2 were 40 and 18 months, respectively. Median kidney survival in participants with diastolic blood pressure (DBP) < 99 mmHg was longer than 60 months, whereas in patients with DBP 100–109 and 110 mmHg, it was 40 and 24 months, respectively. Cox regression analysis included 68 patients. A moderate degree of correlation was found between predicted and observed five-year risk (p = 0.001). Gender, tubular atrophy/interstitial fibrosis, DBP are significant factors affecting kidney survival. Since there was statistically significant correlation and reliability between PT and follow-up analysis data, we conclude that PT could be applied for use in the Latvian population
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Affiliations in Web of Science publication are different from those provided in Scopus database and the original journal publication. Here are given the affiliations from Scopus/original publication in "Proceedings of the Latvian Academy of Sciences. Section B. Natural, Exact, and Applied Sciences".
Keywords
end-stage kidney disease, immunoglobulin A nephropathy, kidney survival risk factors, novel IgAN prediction tool, 3.2 Clinical medicine, 1.1. Scientific article indexed in Web of Science and/or Scopus database
Citation
Saulīte, A J, Popova, A, Erts, R, Rācenis, K, Kučāne, L, Pētersons, A, Laurinavičius, A, Čerņevskis, H & Kuzema, V 2021, 'Renal Survival and Validation of Novel International Immunoglobulin A Nephropathy Prediction Tool in Latvian Population: Preliminary Data', Proceedings of the Latvian Academy of Sciences. Section B. Natural, Exact, and Applied Sciences., vol. 75, no. 5, pp. 379-386. https://doi.org/10.2478/prolas-2021-0055