Assessment of Serum Pepsinogens with and without Co-Testing with Gastrin-17 in Gastric Cancer Risk Assessment—Results from the GISTAR Pilot Study

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dc.contributor.authorRobles, Claudia
dc.contributor.authorRudzite, Dace
dc.contributor.authorPolaka, Inese
dc.contributor.authorSjomina, Olga
dc.contributor.authorTzivian, Lilian
dc.contributor.authorKikuste, Ilze
dc.contributor.authorTolmanis, Ivars
dc.contributor.authorVanags, Aigars
dc.contributor.authorIsajevs, Sergejs
dc.contributor.authorLiepniece-Karele, Inta
dc.contributor.authorRazuka-Ebela, Danute
dc.contributor.authorParshutin, Sergej
dc.contributor.authorMurillo, Raul
dc.contributor.authorHerrero, Rolando
dc.contributor.authorYoung Park, Jin
dc.contributor.authorLeja, Marcis
dc.date.accessioned2023-01-22T11:25:01Z
dc.date.available2023-01-22T11:25:01Z
dc.date.issued2022-07
dc.descriptionFunding Information: The work was partly supported by the Latvian Council of Science (Project No. LZP-2018/1-0135, “Research on implementation of a set of measures for prevention of gastric cancer mortality by eradication of H. pylori and timely recognition of precancerous lesions”). Publisher Copyright: © 2022 by the authors.
dc.description.abstractIntroduction––Serum pepsinogen tests for gastric cancer screening have been debated for decades. We assessed the performance of two pepsinogen assays with or without gastrin-17 for the detection of different precancerous lesions alone or as a composite endpoint in a Latvian cohort. Methods––Within the intervention arm of the GISTAR population-based study, participants with abnormal pepsinogen values by ELISA or latex-agglutination tests, or abnormal gastrin-17 by ELISA and a subset of subjects with all normal biomarker values were referred for upper endoscopy with biopsies. Performance of biomarkers, corrected by verification bias, to detect five composite outcomes based on atrophy, intestinal metaplasia, dysplasia or cancer was explored. Results––Data from 1045 subjects were analysed, of those 273 with normal biomarker results. Both pepsinogen assays showed high specificity (>93%) but poor sensitivity (range: 18.4–31.1%) that slightly improved when lesions were restricted to corpus location (40.5%) but decreased when dysplasia and prevalent cancer cases were included (23.8%). Adding gastrin-17 detection, sensitivity reached 33–45% while specificity decreased (range: 61.1–62%) and referral rate for upper endoscopy increased to 38.6%. Conclusions––Low sensitivity of pepsinogen assays is a limiting factor for their use in population-based primary gastric cancer screening, however their high specificity could be useful for triage.en
dc.description.statusPeer reviewed
dc.format.extent11
dc.format.extent913454
dc.identifier.citationRobles, C, Rudzite, D, Polaka, I, Sjomina, O, Tzivian, L, Kikuste, I, Tolmanis, I, Vanags, A, Isajevs, S, Liepniece-Karele, I, Razuka-Ebela, D, Parshutin, S, Murillo, R, Herrero, R, Young Park, J & Leja, M 2022, 'Assessment of Serum Pepsinogens with and without Co-Testing with Gastrin-17 in Gastric Cancer Risk Assessment—Results from the GISTAR Pilot Study', Diagnostics, vol. 12, no. 7, 1746, pp. 1-11. https://doi.org/10.3390/diagnostics12071746
dc.identifier.doi10.3390/diagnostics12071746
dc.identifier.issn2075-4418
dc.identifier.urihttps://dspace.rsu.lv/jspui/handle/123456789/10164
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=85137376630&partnerID=8YFLogxK
dc.language.isoeng
dc.relation.ispartofDiagnostics
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectgastric cancer prevention
dc.subjectgastrin-17
dc.subjectpublic health
dc.subjectscreening
dc.subjectserum pepsinogens
dc.subject3.2 Clinical medicine
dc.subject3.1 Basic medicine
dc.subject1.1. Scientific article indexed in Web of Science and/or Scopus database
dc.subjectClinical Biochemistry
dc.subjectSDG 3 - Good Health and Well-being
dc.titleAssessment of Serum Pepsinogens with and without Co-Testing with Gastrin-17 in Gastric Cancer Risk Assessment—Results from the GISTAR Pilot Studyen
dc.type/dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article

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