Mandibular chondroblastic type osteosarcoma primarily diagnosed as chondrosarcoma as a result of radiation therapy : a case report

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dc.contributor.authorRone, Alise Elizabete
dc.contributor.authorBāgante, Ieva
dc.contributor.authorVasilcenko, Irina
dc.contributor.authorZariņš, Jānis
dc.contributor.authorDeksnis, Renārs
dc.contributor.authorHasnere, Sigita
dc.contributor.institutionDepartment of Oral and Maxillofacial Surgery and Oral Medicine
dc.date.accessioned2025-03-17T10:10:01Z
dc.date.available2025-03-17T10:10:01Z
dc.date.issued2025-03
dc.description.abstractRadiation therapy is a recognized etiological factor for osteomyelitis, osteoradionecrosis and multiple sarcomas such as chondrosarcoma and osteosarcoma. Here we present a case of mandibular chondroblastic type osteosarcoma induced by radiotherapy which was primarily misdiagnosed as chondrosarcoma. A female presented with main complaint of pain at the extraction site following multiple teeth extraction and sequestrectomy on the right lower jaw. Medical history revealed stage IV squamous cell carcinoma of the base of the tongue which was treated by surgical excision, chemotherapy and radiotherapy ten years ago. Four recurring sequestrectomies were performed, but only histological material from the fourth sequestrectomy revealed grade 2 chondrosarcoma. This was followed by resection of the tumour and floor of the mouth, mandibular, lip and facial skin reconstruction and operation material through histology was again confirmed to be grade 2 chondrosarcomas. In a year’s time, pathological nodule in thyroid gland was found on CT, surgery was performed. Operation material now revealed high grade chondroblastic type osteosarcoma and additional radiotherapy and chemotherapy was prescribed. This case illustrated chondrosarcoma and chondroblastic type osteosarcoma as a rare malignant incidence, with diagnostical difficulties and treatment. Differential diagnosis should be considered if no positive changes are observed after the designated therapy as well as importance of immunohistological evaluation. One treated malignancy does not exclude development of another unrelated malignancy.en
dc.description.statusPeer reviewed
dc.format.extent5
dc.format.extent306650
dc.identifier.citationRone, A E, Bāgante, I, Vasilcenko, I, Zariņš, J, Deksnis, R & Hasnere, S 2025, 'Mandibular chondroblastic type osteosarcoma primarily diagnosed as chondrosarcoma as a result of radiation therapy : a case report', International Journal of Scientific Reports, vol. 11, no. 3, pp. 139-143. https://doi.org/10.18203/issn.2454-2156.IntJSciRep20250351
dc.identifier.doi10.18203/issn.2454-2156.IntJSciRep20250351
dc.identifier.issn2454-2156
dc.identifier.urihttps://dspace.rsu.lv/jspui/handle/123456789/17181
dc.language.isoeng
dc.relation.ispartofInternational Journal of Scientific Reports
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectChondroblastic type osteosarcoma
dc.subjectLingual carcinoma
dc.subjectMandibular chondrosarcoma
dc.subjectRadiation therapy
dc.subject3.2 Clinical medicine
dc.subject1.4. Reviewed scientific article published in Latvia or abroad in a scientific journal with an editorial board (including university editions)
dc.titleMandibular chondroblastic type osteosarcoma primarily diagnosed as chondrosarcoma as a result of radiation therapy : a case reporten
dc.type/dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article

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