Wild-Grown and Cultivated Glechoma hederacea L. : Chemical Composition and Potential for Cultivation in Organic Farming Conditions

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dc.contributor.authorSile, Inga
dc.contributor.authorKrizhanovska, Valerija
dc.contributor.authorNakurte, Ilva
dc.contributor.authorMezaka, Ieva
dc.contributor.authorKalane, Laura
dc.contributor.authorFilipovs, Jevgenijs
dc.contributor.authorVecvanags, Alekss
dc.contributor.authorPugovics, Osvalds
dc.contributor.authorGrinberga, Solveiga
dc.contributor.authorDambrova, Maija
dc.contributor.authorKronberga, Arta
dc.contributor.institutionDepartment of Applied Pharmacy
dc.contributor.institutionDepartment of Pharmaceutical Chemistry
dc.date.accessioned2022-08-16T21:02:48Z
dc.date.available2022-08-16T21:02:48Z
dc.date.issued2022-03-01
dc.descriptionFunding Information: Funding: This work was supported by the European Regional Development Fund project “Innovative solutions for growing technologies and applications of spring medicinal and aromatic plants” (Nr. 1.1.1.1/18/A/043). Publisher Copyright: © 2022 by the authors. Licensee MDPI, Basel, Switzerland.
dc.description.abstractGlechoma hederacea L. is a medicinal plant that is known in traditional medicine for its anti-inflammatory, antibacterial, antiviral, and anticancer properties. This study evaluated the potential for commercial production of G. hederacea and compared the chemical composition and activity of 70% ethanol extracts and steam-distilled essential oils from wild-grown and cultivated G. hederacea collected in different harvesting periods. The main compounds identified in the 70% ethanol extracts were phenolic acids (chlorogenic and rosmarinic acids) and flavonoid O-glycosides. The essential oil varied in the three accessions in the range of 0.32-2.98 mL/kg -1 of dry weight. The extracts possessed potent antioxidant and anti-inflammatory properties in LPS-treated bone-marrow-derived macrophages. The results of flow cytometry show that extracts from different vegetation periods reduced the conversion of macrophages to the proinflammatory phenotype M1. The chemical composition varied the most with the different harvesting periods, and the most suitable periods were the flowering and vegetative phases for the polyphenolic compounds and essential oils, respectively. G. hederacea can be successfully grown under organic farming conditions, and cultivation does not significantly affect the chemical composition and biological activity compared to wild-grown plants.en
dc.description.statusPeer reviewed
dc.format.extent3125218
dc.identifier.citationSile, I, Krizhanovska, V, Nakurte, I, Mezaka, I, Kalane, L, Filipovs, J, Vecvanags, A, Pugovics, O, Grinberga, S, Dambrova, M & Kronberga, A 2022, 'Wild-Grown and Cultivated Glechoma hederacea L. Chemical Composition and Potential for Cultivation in Organic Farming Conditions', Plants, vol. 11, no. 6, 819. https://doi.org/10.3390/plants11060819
dc.identifier.doi10.3390/plants11060819
dc.identifier.issn2223-7747
dc.identifier.otherPubMedCentral: PMC8949430
dc.identifier.otherMendeley: ea4ae360-60fe-3ecd-a4fb-f0b276f334d3
dc.identifier.urihttps://dspace.rsu.lv/jspui/handle/123456789/9395
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=85126642990&partnerID=8YFLogxK
dc.language.isoeng
dc.relation.ispartofPlants
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectChemical composition
dc.subjectCultivation
dc.subjectEssential oils
dc.subjectGlechoma hederacea
dc.subjectHarvesting period
dc.subject1.6 Biological sciences
dc.subject3.1 Basic medicine
dc.subject1.1. Scientific article indexed in Web of Science and/or Scopus database
dc.titleWild-Grown and Cultivated Glechoma hederacea L. : Chemical Composition and Potential for Cultivation in Organic Farming Conditionsen
dc.type/dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article

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