What we need to learn when exploring the mixed basal cell carcinoma of head and neck

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dc.contributor.authorMoisejenko- Goluboviča, Jeļena
dc.contributor.authorVolkovs, Oļegs
dc.contributor.authorIvanova, Anna
dc.contributor.authorPetrošina, Eva
dc.contributor.authorGroma, Valērija
dc.contributor.institutionRīga Stradiņš University
dc.contributor.institutionInstitute of Anatomy and Anthropology
dc.contributor.institutionStatistics Unit
dc.date.accessioned2021-06-04T05:55:01Z
dc.date.available2021-06-04T05:55:01Z
dc.date.issued2021-04-01
dc.descriptionPublisher Copyright: © 2021 Sciendo. All rights reserved.
dc.description.abstractCoexistence of different histopathological types of basal cell carcinomas (BCC) in the same anatomical localisation is rare, and, therefore, is engaging for histopathologists and clinicians. In many cases, the determination of a neoplasm type remains difficult, since BCC may consist of more than one histopathological subtype. Mixed BCCs often present with an aggressive course and recurrence when compared to other subtypes of a tumour. Furthermore, tumours of this type are associated with time-consuming treatment and not a very satisfactory cosmetic result, thus worsening the quality of the patient’s life. Several clinical studies have been published regarding the histopathologically diverse tumours developed in the same anatomical region; however, largely peculiarities of mixed BCCs are not explored sufficiently. The purpose of this study was to substantiate the use of dermoscopy and morphology, assessing mixed type BCC of the head and neck. The tumours were removed with a surgical excision of 1 cm margins, and the tumour sites were assessed in a 24-month-long follow-up period. The dermoscopic characteristics of mixed and aggressive BCC are analysed in this study. Finally, to better estimate the invading cone of the tumour, a complex morphology, which included collagen type IV and podoplanin immunohistochemistry, and electron microscopy were used.en
dc.description.statusPeer reviewed
dc.format.extent11
dc.format.extent8940126
dc.identifier.citationMoisejenko- Goluboviča, J, Volkovs, O, Ivanova, A, Petrošina, E & Groma, V 2021, 'What we need to learn when exploring the mixed basal cell carcinoma of head and neck', Proceedings of the Latvian Academy of Sciences, Section B: Natural, Exact, and Applied Sciences, vol. 75, no. 2, pp. 75-85. https://doi.org/10.2478/prolas-2021-0013
dc.identifier.doi10.2478/prolas-2021-0013
dc.identifier.issn1407-009X
dc.identifier.urihttps://dspace.rsu.lv/jspui/handle/123456789/4701
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=85106255082&partnerID=8YFLogxK
dc.language.isoeng
dc.relation.ispartofProceedings of the Latvian Academy of Sciences, Section B: Natural, Exact, and Applied Sciences
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectCollagen IV immunohistochemistry
dc.subjectDermoscopy
dc.subjectElectron microscopy
dc.subjectMixed type
dc.subjectPodoplanin
dc.subject3.1 Basic medicine
dc.subject3.2 Clinical medicine
dc.subject1.1. Scientific article indexed in Web of Science and/or Scopus database
dc.subjectGeneral
dc.titleWhat we need to learn when exploring the mixed basal cell carcinoma of head and necken
dc.type/dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article

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