Nieru transplantāta kvalitātes salīdzinājums starp multi-orgānu donoriem un nieru donoriem
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Date
2022
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Rīgas Stradiņa universitāte
Rīga Stradiņš University
Rīga Stradiņš University
Abstract
Nieres visbiežāk tiek iegūtas no mirušiem donoriem, kas ir vainu tikai nieru donori vai multi-orgānu donori, un tie krietni atšķiras ar išēmijas laiku. Pētījuma mērķis bija noskaidrot, vai šī atšķirība ietekmē transplantāta funkcijas iznākumu, un vai būtu nepieciešams apsvērt kādus transplantāta ieguves metožu uzlabojumus. Šāda atradne palīdzētu izveidot piemērotākus donoru-recipientu pārus un palīdzētu sasniegt transplantātu pilno potenciālu.
Petījuma rezultāti liecina, ka nepastāv nozīmīgas atšķirības nieru transplantāta funkcionalitātē starp abām grupām. Lai gan donoru sagatavošanas laiks ir divreiz augstāks multi-orgānu grupā, laboratorās analīzes liecina, ka nieres, kas iegūtas no šīs grupas donoriem, funkcionē mazliet labāk, tomēr tas varētu būt saistīts arī ar donoru vecuma atšķirību.
Kidneys are most commonly obtained from deceased donors, which can be either kidney-only donors (KOD) or multi-organ donors (MOD), which significantly differ in the time of ischemia. Our aim was to determine whether this difference affects the outcome of the graft functionality and if there should be any method improvements considered. Such findings could assist in creating more suitable donor-recipient pairs and help maximise full potential of the grafts. To conclude - there are no statistically significant differences in the results of kidney graft function between the two groups. Although the time of donor preparation is twice as high in the MOD group, laboratory analysis indicate that the grafts received from this group function slightly better, however, this may be due to the donor age difference.
Kidneys are most commonly obtained from deceased donors, which can be either kidney-only donors (KOD) or multi-organ donors (MOD), which significantly differ in the time of ischemia. Our aim was to determine whether this difference affects the outcome of the graft functionality and if there should be any method improvements considered. Such findings could assist in creating more suitable donor-recipient pairs and help maximise full potential of the grafts. To conclude - there are no statistically significant differences in the results of kidney graft function between the two groups. Although the time of donor preparation is twice as high in the MOD group, laboratory analysis indicate that the grafts received from this group function slightly better, however, this may be due to the donor age difference.
Description
Medicīna
Medicine
Veselības aprūpe
Health Care
Medicine
Veselības aprūpe
Health Care
Keywords
nieru transplantācija, nieru transplantāts, multi-orgānu donors, tikai nieru donors, transplantāta funkcija, kidney transplantation, kidney graft, multi-organ donor, kidney-only donor, graft function