A novel sol-gel Bi2-xHfxO3+x/2 radiopacifier for mineral trioxide aggregates (MTA) as dental filling materials

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dc.contributor.authorYang, Tzu Sen
dc.contributor.authorChen, May Show
dc.contributor.authorHuang, Cheng Jyun
dc.contributor.authorChen, Chin Yi
dc.contributor.authorBrangule, Agnese
dc.contributor.authorZarkov, Aleksej
dc.contributor.authorKareiva, Aivaras
dc.contributor.authorLin, Chung Kwei
dc.contributor.authorYang, Jen Chang
dc.contributor.institutionDepartment of Pharmaceutical Chemistry
dc.date.accessioned2021-08-19T10:40:01Z
dc.date.available2021-08-19T10:40:01Z
dc.date.issued2021-08-02
dc.descriptionFunding Information: The authors would like to thank Taipei Medical University Hospital for financially sup-porting this work under grant no. 110TMU-TMUH-16 and partially supported by MOST 109-2221-E-038-014. Publisher Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland.
dc.description.abstractMineral trioxide aggregate (MTA) is well known as an effective root canal filling material for endodontics therapy. Within MTA, bismuth oxide (Bi2O3) serving as the radiopacifier still has biocompatibility concerns due to its mild cytotoxicity. In the present study, we tried to modify the Bi2O3 radiopacifier by doping hafnium ions via the sol-gel process and investigated the effects of different doping ratios (Bi2-xHfxO3+x/2, x = 0–0.3) and calcination temperatures (400–800 °C). We mixed various precursor mixtures of bismuth nitrate (Bi(NO3)3·5H2O) and hafnium sulfate (Hf(SO4)2) and controlled the calcination temperatures. The as-prepared Hf-doped Bi2O3 radiopaci-fier powders were investigated by thermogravimetric analysis (TGA), X-ray diffraction (XRD), field-emission scanning electron microscopy (FESEM), and transmission electron microscopy (TEM). Portland cement/radiopacifier/calcium sulfate (75/20/5) were mixed and set by deionized water (powder to water ratio = 3:1). Changes in radiopacity, diametral tensile strength (DTS), and in vitro cell viability of the hydrated MTA-like cement were carried out. The experimental results showed that the group containing radiopacifier from sol-gelled Bi/Hf (90/10) exhibited significantly higher radiopacity (6.36 ± 0.34 mmAl), DTS (2.54 ± 0.29 MPa), and cell viability (84.0±8.1%) (p < 0.05) when compared to that of Bi/Hf (100/0) powders. It is suggested that the formation of β-Bi7.78Hf0.22O12.11 phase with hafnium addition and calcining at 700 °C can prepare novel bismuth/haf-nium composite powder that can be used as an alternative radiopacifier for root canal filling mate-rials.en
dc.description.statusPeer reviewed
dc.format.extent4330145
dc.identifier.citationYang, T S, Chen, M S, Huang, C J, Chen, C Y, Brangule, A, Zarkov, A, Kareiva, A, Lin, C K & Yang, J C 2021, 'A novel sol-gel Bi 2-x Hf x O 3+x/2 radiopacifier for mineral trioxide aggregates (MTA) as dental filling materials', Applied Sciences (Switzerland), vol. 11, no. 16, 7292. https://doi.org/10.3390/app11167292
dc.identifier.doi10.3390/app11167292
dc.identifier.issn2076-3417
dc.identifier.urihttps://dspace.rsu.lv/jspui/handle/123456789/6050
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=85112329261&partnerID=8YFLogxK
dc.language.isoeng
dc.relation.ispartofApplied Sciences (Switzerland)
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectBiocompatibility
dc.subjectMineral trioxide aggregate
dc.subjectRadiopacity
dc.subjectSol-gel
dc.subject3.1 Basic medicine
dc.subject3.4 Medical biotechnology
dc.subject1.4 Chemical sciences
dc.subject1.1. Scientific article indexed in Web of Science and/or Scopus database
dc.subjectGeneral Materials Science
dc.subjectInstrumentation
dc.subjectGeneral Engineering
dc.subjectProcess Chemistry and Technology
dc.subjectComputer Science Applications
dc.subjectFluid Flow and Transfer Processes
dc.titleA novel sol-gel Bi2-xHfxO3+x/2 radiopacifier for mineral trioxide aggregates (MTA) as dental filling materialsen
dc.type/dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article

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