Il-6 and Il-10 Expression in Brain Tissue in Children and Adults after Fatal Traumatic Brain Injury

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dc.contributor.authorBārzdiņa, Arta
dc.contributor.authorPilmane, Māra
dc.contributor.authorPētersons, Aigars
dc.contributor.institutionRīga Stradiņš University
dc.contributor.institutionInstitute of Anatomy and Anthropology
dc.date.accessioned2021-12-10T09:30:01Z
dc.date.available2021-12-10T09:30:01Z
dc.date.issued2011
dc.description.abstractIntroduction. One of the leading secondary damage processes determining the outcome of head injury is cerebral ischemia. The inflammatory reactions are important factors in cases of ischemic brain damage. Some studies characterize generalized reactions of cytokines in brain, but there are less studies about inflammatory reactions in the determined areas of the brain in different time points. Aim of the study. To determine the reaction of brain tissue after fatal brain injury in different time points after the trauma, by detecting IL-6 in the pyramidal neurons of CNS gray matter (GM) and in the white substance (WS) and IL-10 in the WS of the impact and counterstroke areas. Materials and methods. We used brain tissue material from the trauma and counterstroke spots of 11 patients died after fatal traumatic brain injury in different time points. Brain tissue specimens were routinely fixed, embedded into paraffin, cut in 5 μm thick slides. For immunohistochemistry we used monoclonal antibodies against recombinant IL-6 of human origin and polyclonal rabbit antibodies against IL-10 of human. Results. There were found statistically significant differences in IL-6 positive neurons in the GM, and IL-6 and IL-10 positive glial cell numbers in the WS in the spot of counterstroke and in the spot of direct impact in both patient groups (Mann-Whitney U Test p ≤ 0,001 for all groups). Conclusions. The IL-6 and IL-10 positive glial cell numbers correlate with the outcome of trauma. The inflammatory reaction in the WS in the spot of counterstroke was more marked than in the spot of direct impact. The activity of inflammatory reaction depends on the time period after the traumatic event.en
dc.description.statusPeer reviewed
dc.format.extent6378853
dc.identifier.citationBārzdiņa, A, Pilmane, M & Pētersons, A 2011, 'Il-6 and Il-10 Expression in Brain Tissue in Children and Adults after Fatal Traumatic Brain Injury', Acta Chirurgica Latviensis, no. 11, pp. 67-73.
dc.identifier.issn2199-5737
dc.identifier.urihttps://dspace.rsu.lv/jspui/handle/123456789/7019
dc.language.isoeng
dc.relation.ispartofActa Chirurgica Latviensis
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectTraumatic brain injury
dc.subjectcerebral ischemia
dc.subjectsecondary brain damage
dc.subjectcytokine IL-6
dc.subjectcytokine IL-10
dc.subjectinflammatory reactions
dc.subject3.1 Basic medicine
dc.subject3.2 Clinical medicine
dc.subject1.4. Reviewed scientific article published in Latvia or abroad in a scientific journal with an editorial board (including university editions)
dc.titleIl-6 and Il-10 Expression in Brain Tissue in Children and Adults after Fatal Traumatic Brain Injuryen
dc.type/dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article

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