Browsing by Author "Voicehovskis, Vladimirs"
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Item Atrial fibrillation, oral anticoagulants and health related quality of life(2018-12) Apsite, Ketija; Luriņa, Baiba; Tupahins, Andris; Voicehovskis, Vladimirs; Ivascenko, Tarass; Kalejs, Oskars; Lejnieks, Aivars; Faculty of Medicine; Department of Internal Diseases; Department of Doctoral StudiesIntroduction: Atrial fibrillation (AFib) is a disease that can influence the health related quality of life. Also oral anticoagulants can influence it both because of its therapeutic benefits or complications as well as how the anticoagulant usage influence the person's life style by regular laboratory test necessity or diet restrictions. Aim: Determine and analyze whether there is a statistically significant difference comparing health related quality of life between K vitamin antagonist, warfarin, users, novel anticoagulant (NOAC), rivaroxaban, dabigatran, users and patients, who do not use any kind of oral anticoagulant. Materials and methods: A cross-sectional analytic research was made in Pauls Stradins Clinical university hospital, Center of Cardiology in Riga, Latvia during the time period from October 2016 till June 2017. Persons with high-risk non-valvular atrial fibrillation were offered to participate in this research. If the person agreed, an oral interview with questions about disease anamnesis, demographic data, laboratory test results, echocardiography results, modified SF-36 survey, used oral anticoagulant type was held. Data were precised with the help of the case anamnesis information. For statistical data analysis was used SPSS Statistics database. Results: Altogether 218 patients were enrolled, of which 56.9% were female and 43.1% – male, mean age – 70.4 years, mean CHA2D2-VASc score – 4.4. Warfarin used 37.6%, 33.0% – novel oral anticoagulants, but 29.4% did not use any kind of oral anticoagulant. A statistically significant difference was discovered between the mean ranks in physical functioning sections comparing warfarin (mean rank 95.85) with NOACs (mean rank 124.57); p = 0.012. Also a statistically significant difference was in social functioning comparing warfarin (mean rank 96.16) with NOACs (mean rank 119.08); p = 0.026. Age had low negative correlation (r = −0.23) with physical functioning. Duration of atrial fibrillation diagnosis did not have correlations with the results. Conclusion: NOAC usage correlates with the best health related quality of life scores, gaining a statistically significant difference compared to warfarin users in physical functioning (warfarin – 95.85, NOACs – 124.57; p = 0.012) and social functioning mean ranks (warfarin – 95.16, NOACs – 119.08; p = 0.026). Age had low negative correlation with physical functioning scores.Item Biomarkers in community-acquired pneumonia assessment(2017-04) Voskresenska, Natalja; Babikovs, Sergejs; Voicehovska, Julija; Sķesters, Andrejs; Silova, Alise; Voicehovskis, Vladimirs; Aleksejeva, Renija; Lejnieks, Aivars; Karpovs, Jurijs; Department of Internal Diseases; Bioķīmijas zinātniskā laboratorijaThe paper presents information on pneumonia (P) patients with features of oxidative stress (OS). Identifying features of OS in patients with P is of interest not only for diagnosis, but also for monitoring of treatment efficiency. We recruited 73 patients with community-acquired P (CAP), previously healthy adults, both males and females with mean age of 68.0 ± 15.2, hospitalised, and 61 healthy control patients matched for age. For quantitative evaluation of lipid peroxidation in CAP patients, the levels of aldehydic lipid peroxidation products like malondialdehyde (MDA) and 4-hydroxynon-2-enal (HNE) were quantified. Furthermore, concentrations of reduced glutathione (GSH) and several antioxidant enzymes and selenium in plasma were determined. In CAP patients, decreased levels of GSH and plasma selenium were observed. Plasma levels of MDA, and HNE did significantly differ between patient and control groups. We also noted reduced activity of antioxidant enzymes, namely, glutation peroxidase and superoxide dismutase. Low antioxidant enzymes activity was associated with a more severe CAP pattern. Both GSH and antioxidant enzymes may serve as markers for inflammation-related OS in CAP patients, and measurement of these biomarkers may be a valid indentifier for its management.Item Combined medical treatment of chronic pancreatitis(2015-04-01) Umnova, Larisa; Orlikovs, Grigorijs; Voicehovska, Julija; Voicehovskis, Vladimirs; Krustiņš, Eduards; Department of Internal DiseasesThe aim of the study was to determine the most effective medical treatment of patients with chronic pancreatitis, by using either pancreatin alone or in combination with proton pump inhibitor (PPI) or PPI and non-steroidal anti-inflammatory drug (NSAID). Patients with chronic pancreatitis, who did not require a surgical treatment, received medical treatment for a one-month period: 20 patients received pancreatin monotherapy; 48 patients were given a combination of pancreatin and PPI; 38 patients were treated with a combination of pancreatin, PPI and NSAID (PNP therapy group). In comparison with other groups, patients in the PNP therapy group showed improvement in body mass index, abdominal pain, bowel movements, chronic pancreatitis severity, as well as their quality of life assessment (p < 0.05). The combination of pancreatin, PPI and NSAID was the most effective among those applied in chronic pancreatitis patient treatment. A one-month long course of this therapy was safe and did not cause any significant adverse effects. The combination of pancreatin, PPI and NSAID for treatment of chronic pancreatitis can be recommended, as it is based on pathogenesis of the disease, effective, safe and economically advantageous.Item Gpx and MDA Oxidative Stress Markers and Severity of Depression as Predictives of Recurrent Stable Coronary Heart Disease. Doctoral Thesis(Rīga Stradiņš University, 2023) Ivaščenko, Tarass; Voicehovskis, Vladimirs; Kalējs, OskarsBackground. Cardiovascular disease is a major cause of death globally, taking over one-third of all deaths worldwide. Multiple research results are confirming coronary heart disease and depression as highly comorbid, associating depression with an increased risk of incidents of coronary heart disease and vice versa, and depression is a strong predictor of coronary heart disease outcome. One of the mechanisms that may explain the interaction between depression and cardiovascular diseases is oxidative stress. Assessment of oxidative stress markers could modify risk stratification, diagnosis and prevention, and treatment of coronary heart disease and depression patients. Aim. To investigate the relationships between oxidative stress biomarkers, the prevalence of depression, and the risk of recurrent stable coronary heart disease. Methods. A retrospective case-control study, comparing patients with primary stable coronary heart disease with patients who have recurrent stable coronary heart disease by determining oxidative markers levels and depression signs and severity. Medical record analysis, structured interview, Geriatric Depression Scale, and blood samples to detect oxidative stress markers MDA and GPx were used as investigation methods. Results and discussion. 174 patients were included in this study – 49.4% with primary coronary heart disease and 50.6% with recurrent. The majority of the sample (83.9%) had high levels of MDA and for the rest of them, the MDA level was considered normal. MDA level was slightly higher in primary stable coronary heart disease group without depression. For the majority of the patients (72.4%) the GPx level was normal, for 17.8% it was high, and for 9.8% – low. Slightly more than half of the patients were experiencing depression (44.3% – mild and 6.9% – severe). Oxidative stress is a risk factor for coronary heart recurrence, especially in depressed patients. The prevalence of depression was higher in patients with recurrent coronary heart disease. Patients with both high GPx and depression had 10.6 times higher chances of recurrent stable coronary heart disease compared to those with normal GPx and without depression. Conclusions. Elevated GPx level was more common among patients with recurrent stable coronary heart disease. GPx levels were also higher in depressed patients with recurrent stable coronary heart disease. The majority of patients had high levels of MDA with higher rates in patients with primary stable coronary heart disease. More than a half of patients were experiencing mild or severe depression symptoms with higher rates among patients with recurrent stable coronary heart disease. Patients with high GPx and depression have higher chances of recurrent stable coronary heart disease. Increased MDA level is a risk factor for stable coronary heart disease in general but it does not link to depression severity and recurrence of stable coronary heart disease. Hence antioxidant enzyme GPx is a more significant marker of the risk of depression and recurrence of stable coronary heart disease.Item Gpx and MDA Oxidative Stress Markers and Severity of Depression as Predictives of Recurrent Stable Coronary Heart Disease. Summary of the Doctoral Thesis(Rīga Stradiņš University, 2023) Ivaščenko, Tarass; Voicehovskis, Vladimirs; Kalējs, OskarsBackground. Cardiovascular disease is a major cause of death globally, taking over one-third of all deaths worldwide. Multiple research results are confirming coronary heart disease and depression as highly comorbid, associating depression with an increased risk of incidents of coronary heart disease and vice versa, and depression is a strong predictor of coronary heart disease outcome. One of the mechanisms that may explain the interaction between depression and cardiovascular diseases is oxidative stress. Assessment of oxidative stress markers could modify risk stratification, diagnosis and prevention, and treatment of coronary heart disease and depression patients. Aim. To investigate the relationships between oxidative stress biomarkers, the prevalence of depression, and the risk of recurrent stable coronary heart disease. Methods. A retrospective case-control study, comparing patients with primary stable coronary heart disease with patients who have recurrent stable coronary heart disease by determining oxidative markers levels and depression signs and severity. Medical record analysis, structured interview, Geriatric Depression Scale, and blood samples to detect oxidative stress markers MDA and GPx were used as investigation methods. Results and discussion. 174 patients were included in this study – 49.4% with primary coronary heart disease and 50.6% with recurrent. The majority of the sample (83.9%) had high levels of MDA and for the rest of them, the MDA level was considered normal. MDA level was slightly higher in primary stable coronary heart disease group without depression. For the majority of the patients (72.4%) the GPx level was normal, for 17.8% it was high, and for 9.8% – low. Slightly more than half of the patients were experiencing depression (44.3% – mild and 6.9% – severe). Oxidative stress is a risk factor for coronary heart recurrence, especially in depressed patients. The prevalence of depression was higher in patients with recurrent coronary heart disease. Patients with both high GPx and depression had 10.6 times higher chances of recurrent stable coronary heart disease compared to those with normal GPx and without depression. Conclusions. Elevated GPx level was more common among patients with recurrent stable coronary heart disease. GPx levels were also higher in depressed patients with recurrent stable coronary heart disease. The majority of patients had high levels of MDA with higher rates in patients with primary stable coronary heart disease. More than a half of patients were experiencing mild or severe depression symptoms with higher rates among patients with recurrent stable coronary heart disease. Patients with high GPx and depression have higher chances of recurrent stable coronary heart disease. Increased MDA level is a risk factor for stable coronary heart disease in general but it does not link to depression severity and recurrence of stable coronary heart disease. Hence antioxidant enzyme GPx is a more significant marker of the risk of depression and recurrence of stable coronary heart disease.Item Oksidatīvā stresa marķieri GPx un MDA un depresijas smagums kā atkārtotu stabilas koronārās sirds slimības notikumu prognostiskie faktori. Promocijas darba kopsavilkums(Rīgas Stradiņa universitāte, 2023) Ivaščenko, Tarass; Voicehovskis, Vladimirs; Kalējs, OskarsIevads. Kardiovaskulārās slimības ir galvenais nāves cēlonis pasaulē – vairāk nekā trešdaļai visu nāvju. Vairāki pētījumu dati apstiprina, ka koronārajai sirds slimībai un depresijai ir augsta komorbiditāte, depresija ir saistīta ar paaugstinātu koronārās sirds slimības attīstības risku, un otrādi, kā arī depresija ir spēcīgs koronārās sirds slimības iznākuma prognostiskais faktors. Viens no galvenajiem mehānismiem, kas izskaidro mijiedarbību starp depresiju un koronāro sirds slimību, ir oksidatīvais stress. Oksidatīvā stresa marķieru novērtēšana var savlaicīgi mazināt atkārtotas hospitalizācijas risku sakarā ar koronāro sirds slimību, uzlabot diagnozes noteikšanu, ārstēšanu un profilaksi pacientiem ar koronāro sirds slimību un depresiju. Mērķis. Izpētīt oksidatīvā stresa biomarķieru līmeņa izmaiņas un to iespējamo prevalējošo korelāciju ar depresiju un atkārtotu stabilas koronārās sirds slimības (SKSS) notikumu riskiem. Metodes. Retrospektīvs gadījumu kontroles pētījums, kurā salīdzināti pacienti ar primāru un atkārtotu koronārās sirds slimības notikumu, nosakot oksidatīvā stresa marķieru līmeni un depresijas smagumu. Tika izmantotas šādas metodes: medicīnisko ierakstu analīze, strukturētas pacientu intervijas, geriatrijas depresijas skala, asins analīzes MDA un GPx līmeņa noteikšanai. Rezultāti un diskusija. Pētījumā tika iekļauti 174 pacienti: 49,4 % ar primāru stabilu koronārās sirds slimības notikumu un 50,6 % ar atkārtotu notikumu. Lielākajai izlases daļai (83,9 %) bija augsti MDA rādītāji, bet pārējiem MDA bija normas robežās. MDA līmenis bija nedaudz augstāks pacientiem bez depresijas ar primāru stabilu koronāro sirds slimību. Lielākajai daļai pacientu (72,4 %) GPx līmenis bija normāls, 17,8 % tas bija augsts, bet 9,8 % – zems. Nedaudz vairāk nekā pusei pacientu konstatēja depresiju (44,3 % vidēji smagu un 6,9 % smagu). Oksidatīvais stress ir viens no riska faktoriem atkārtotai stabilai koronārajai sirds slimībai, it īpaši pacientiem ar depresiju. Depresijas izplatība bija augstāka pacientiem ar atkārtotu stabilas koronārās sirds slimības notikumu. Pacientiem ar augstu GPx līmeni un depresiju ir 10,6 reizes augstāks risks, ka koronārā sirds slimība attīstīsies atkārtoti salīdzinājumā ar pacientiem bez depresijas un ar normālu GPx līmeni. Secinājumi. Paaugstināts GPx līmenis ir biežāk sastopams pacientiem ar atkārtotu stabilas koronārās sirds slimības notikumu. GPx līmenis bija augstāks depresīviem pacientiem ar atkārtotu stabilas koronārās sirds slimības notikumu. Lielākajai daļai pacientu bija augsts MDA ar augstākiem rādītājiem pacientiem ar primāru stabilu koronāro sirds slimību. Vairāk nekā pusei pacientu tika konstatēti vidēji smagas vai smagas depresijas simptomi ar augstākiem rādītājiem pacientiem ar atkārtotu stabilu koronāro sirds slimību. Pacientiem ar augstu GPx līmeni un depresiju ir augstāki atkārtotu stabilas koronārās sirds slimības notikumu riski. Paaugstināts MDA līmenis ir riska faktors stabilai koronārajai sirds slimībai kopumā, bet nav saistīts ar depresijas smagumu un atkārtotu stabilas koronārās sirds slimības notikumu varbūtību. Līdz ar to GPx ir nozīmīgāks depresijas un atkārtotu stabilas koronārās sirds slimības notikumu riska faktors.Item Oxidative stress parameters in Posttraumatic Stress Disorder risk group patients(2012) Voicehovskis, Vladimirs; Ancane, Gunta; Voicehovska, Julija; Orlikovs, Grigorijs; Karpovs, Jurijs; Ivanovs, Igors; Škesters, Andrejs; Ancans, Andrejs; Silova, Alise; Ivaščenko, Tarass; Micans, Janis; Vaivads, Normunds; Umnova, Larisa; Department of Psychosomatic Medicine and Psychotherapy; Department of Internal Diseases; Bioķīmijas zinātniskā laboratorija; Department of PathologyIncreased excitotoxity in response to stressors leads to oxidative stress (OS) due to accumulation of excess reactive oxygen/nitrogen species. Neuronal membrane phospholipids are especially susceptible to oxidative damage, which alters signal transduction mechanisms. The Contingent of International Operations (CIO) has been subjected to various extreme stressors that could cause Posttraumatic Stress Disorder (PTSD). Former studies suggest that heterogeneity due to gender, race, age, nutritional condition and variable deployment factors and stressors produce challenges in studying these processes. The research aim was to assess OS levels in the PTSD risk group in CIO. In a prospective study, 143 participants who were Latvian CIO, regular personnel, males, Europeans, average age of 27.4, with the same tasks during the mission, were examined two months before and immediately after a six-month Peace Support Mission (PSM) in Afghanistan. PCL-M questionnaire, valid Latvian language "Military" version was used for PTSD evaluation. Glutathione peroxidase (GPx), superoxide dismutase (SOD) and lipid peroxidation intensity and malondialdehyde (MDA) as OS indicators in blood were determined. Data were processed using SPSS 20.0. The MDA baseline was 2.5582 μM, which after PSM increased by 24.36% (3.1815 μM). The GPx baseline was 8061.98 U/L, which after PSM decreased by 9.35% (7308.31 U/L). The SOD baseline was 1449.20 U/gHB, which after PSM increased by 2.89% (1491.03 U/gHB). The PTSD symptom severity (total PCL-M score) baseline was 22.90 points, which after PSM increased by 14.45% (26.21 points). The PTSD Prevalence rate (PR) baseline was 0.0357, which after PSM increased by 147.06% (0.0882). We conclude that there is positive correlation between increase of OS, PTSD symptoms severity level, and PTSD PR in a group of patients with risk of PTSD - CIO. PTSD PR depends on MDA intensity and OS severity. OS and increased free radical level beyond excitotoxity, is a possible causal factor for clinical manifestation of PTSD.Item Posttraumatic Stress Disorder and Oxidative Stress Parameters Assessment and Correction by Means of Antioxidants in Contingent of International Operations. Summary of the Doctoral Thesis(Rīga Stradiņš University, 2012) Voicehovskis, Vladimirs; Ancāne, Gunta; Šķesters, AndrejsThe Contingent of International Operations Combats are a subject for several extreme stressors that can cause Posttraumatic stress disorder (PTSD). PTSD changes the quality of life to a significantly lower level, worsens forecast and progress of comorbid disorders. This problem is of a medically social kind and is up to date in all the countries whose armed forces take part in the Peace Support Missions. The basis of PTSD pathogenesis is hyperactivation of neurones under stress factors influence, socalled excitotoxicity, that causes oxidative stress (OS), because of an accumulation of free radicals. Neurons are especially susceptible to OS, changing signal transduction mechanisms that can cause PTSD. Research aim: to access PTSD incidence, OS parameters and their adjustment advances using antioxidants in PTSD risk group patients. Prospective placebo-controlled randomized study was realized in Riga Stradins University in cooperation with Latvian National armed forces Medical support centre. 143 participants of one 6-months mission, Latvian CIO, were examined two months before mission and immediately after the return. “Selenium” group received organic selenium during the mission. Questionnaires PCL-M were used for PTSD evaluation; OS rates and Se in blood were determined. Basing on the research results, we can conclude that: 1) there is a statistically reliable correlations between the incidence of PTSD and OS parameters, between PTSD symptomatic severity and OS parameters; 2) the use of antioxidant Selenium during the mission can reduce the OS parameters, minimize the incidence of PTSD and reduce the PTSD symptomatic severity. The novelty and practical significance of the research: 1) intellectual property related with study results is protected with the Latvian and the International patents “Preparation that effectively reduces high glutamate level in blood”; 2) PCL-M questionnaire validated Latvian language version can be recommended for use as an effective instrument for PTSD diagnostics and screening in military contingent; 3) invented practical method of PTSD risk groups morbidity diminishing (in field conditions as well) is recommended for use to mission combats and widespread use; 4) the first OS and PTSD parameters correlation assessment; 5) the first study Se using advances to reduce PTSD incidence in a risk group; 6) the first wide-scaled research in Latvian Military medicine and Psychosomatic medicine branches.Item Starptautisko operāciju kontingenta dažu oksidatīvā stresa rādītāju kā posttraumatiskā stresa sindroma izpausmes noteikšana un korekcija, izmantojot antioksidantus. Promocijas darba kopsavilkums(Rīgas Stradiņa universitāte, 2012) Voicehovskis, Vladimirs; Ancāne, Gunta; Šķesters, AndrejsStarptautisko operāciju kontingenta karavīri ir pakļauti dažādiem ekstremāliem faktoriem, kas var izraisīt posttraumatisko stresa sindromu (PTSS). PTSS būtiski pazemina dzīves kvalitāti, pasliktina komorbīdu stāvokļu prognozi un norisi. Šai problēmai ir medicīniski sociāls raksturs, tā ir aktuāla visām tām valstīm, kuru bruņotie spēki piedalās miera uzturēšanas misijās. PTSS patoģenēzes pamatā ir neironu hiperaktivācija stresoru ietekmē – eksaitotoksicitāte, kas izraisa oksidatīvo stresu (OS), jo uzkrājas brīvie radikāļi. Neironi ir īpaši jutīgi pret OS, tāpēc notiek signālu pārraides traucējumi, kas var izraisīt PTSS. Darba mērķis: pacientiem ar PTSS attīstības risku izpētīt saslimstību ar PTSS, dažus OS rādītājus un korekcijas iespējas, izmantojot antioksidantus. Prospektīvais placebo kontrolētais randomizētais pētījums veikts Rīgas Stradiņa universitātē sadarbībā ar LR Nacionālo bruņoto spēku Militārās medicīnas centru. Tika pētīti 143 vienas misijas (6 mēn.) dalībnieki, Latvijas starptautisko operāciju kontingents. “Selēna” grupa misijas laikā saņēma organisko selēnu. Divus mēnešus pirms misijas un tūlīt pēc atgriešanās tika veikta klīniskā izmeklēšana: PTSS diagnostika, izmantojot PCL-M anketu, OS rādītāji un Se saturs asinīs. Balstoties uz darba rezultātiem, varam secināt, ka: 1) ir statistiski ticama sakarība starp saslimstību ar PTSS un OS rādītājiem, starp PTSS simptomātikas smaguma pakāpi un OS rādītājiem; 2) antioksidanta selēna lietošana misijas laikā ļauj pazemināt OS rādītājus, minimizēt saslimstību ar PTSS un pazemināt PTSS simptomātikas smaguma pakāpi. Darba novitāte un praktiskā nozīme: 1) ar pētījuma rezultātiem saistītais intelektuālais īpašums ir aizsargāts ar Latvijas un starptautisko patentiem ”Līdzeklis efektīvai augsta glutamāta līmeņa pazemināšanai asinīs” un “Preparation that effectively reduces high glutamate level in blood”; 2) validizētā PCL-M anketa latviešu valodā tiek rekomendēta kā ērts un efektīvs instruments militārā kontingenta PTSS diagnostikai un skrīningam; 3) izstrādātā praktiskā metode PTSS saslimstības samazināšanai riska grupām (tajā skaitā lauka apstākļos) tiek rekomendēta misijas dalībniekiem un plašai izmantošanai; 4) pirmo reizi tiek veikts OS un PTSS rādītāju savstarpējās saistības novērtējums; 5) pirmo reizi tiek pētīta iespēja izmantot selēnu PTSS saslimstības samazināšanai riska grupās; 6) pirmais plaša mēroga zinātnisks pētījums Latvijā kara medicīnas un psihosomatiskās medicīnas nozarē.Item Starptautisko operāciju kontingenta dažu oksidatīvā stresa rādītāju kā posttraumatiskā stresa sindroma izpausmes noteikšana un korekcija, izmantojot antioksidantus. Promocijas darbs(Rīgas Stradiņa universitāte, 2012) Voicehovskis, Vladimirs; Ancāne, Gunta; Šķesters, AndrejsStarptautisko operāciju kontingenta karavīri ir pakļauti dažādiem ekstremāliem faktoriem, kas var izraisīt posttraumatisko stresa sindromu (PTSS). PTSS būtiski pazemina dzīves kvalitāti, pasliktina komorbīdu stāvokļu prognozi un norisi. Šai problēmai ir medicīniski sociāls raksturs, tā ir aktuāla visām tām valstīm, kuru bruņotie spēki piedalās miera uzturēšanas misijās. PTSS patoģenēzes pamatā ir neironu hiperaktivācija stresoru ietekmē – eksaitotoksicitāte, kas izraisa oksidatīvo stresu (OS), jo uzkrājas brīvie radikāļi. Neironi ir īpaši jutīgi pret OS, tāpēc notiek signālu pārraides traucējumi, kas var izraisīt PTSS. Darba mērķis: pacientiem ar PTSS attīstības risku izpētīt saslimstību ar PTSS, dažus OS rādītājus un korekcijas iespējas, izmantojot antioksidantus. Prospektīvais placebo kontrolētais randomizētais pētījums veikts Rīgas Stradiņa universitātē sadarbībā ar LR Nacionālo bruņoto spēku Militārās medicīnas centru. Tika pētīti 143 vienas misijas (6 mēn.) dalībnieki, Latvijas starptautisko operāciju kontingents. “Selēna” grupa misijas laikā saņēma organisko selēnu. Divus mēnešus pirms misijas un tūlīt pēc atgriešanās tika veikta klīniskā izmeklēšana: PTSS diagnostika, izmantojot PCL-M anketu, OS rādītāji un Se saturs asinīs. Balstoties uz darba rezultātiem, varam secināt, ka: 1) ir statistiski ticama sakarība starp saslimstību ar PTSS un OS rādītājiem, starp PTSS simptomātikas smaguma pakāpi un OS rādītājiem; 2) antioksidanta selēna lietošana misijas laikā ļauj pazemināt OS rādītājus, minimizēt saslimstību ar PTSS un pazemināt PTSS simptomātikas smaguma pakāpi. Darba novitāte un praktiskā nozīme: 1) ar pētījuma rezultātiem saistītais intelektuālais īpašums ir aizsargāts ar Latvijas un starptautisko patentiem ”Līdzeklis efektīvai augsta glutamāta līmeņa pazemināšanai asinīs” un “Preparation that effectively reduces high glutamate level in blood”; 2) validizētā PCL-M anketa latviešu valodā tiek rekomendēta kā ērts un efektīvs instruments militārā kontingenta PTSS diagnostikai un skrīningam; 3) izstrādātā praktiskā metode PTSS saslimstības samazināšanai riska grupām (tajā skaitā lauka apstākļos) tiek rekomendēta misijas dalībniekiem un plašai izmantošanai; 4) pirmo reizi tiek veikts OS un PTSS rādītāju savstarpējās saistības novērtējums; 5) pirmo reizi tiek pētīta iespēja izmantot selēnu PTSS saslimstības samazināšanai riska grupās; 6) pirmais plaša mēroga zinātnisks pētījums Latvijā kara medicīnas un psihosomatiskās medicīnas nozarē.