Browsing by Author "Straume, Zane"

Now showing 1 - 5 of 5
  • No Thumbnail Available
    Item
    Exploring the Impact of COVID-19 on Ulcerative Colitis Patients : A Lifestyle Perspective
    (2024-01) Straume, Zane; Krūmiņa, Nikola; Elbere, Ilze; Rozenberga, Maija; Rudzīte, Dace; Proskurina, Anna; Juliana, Ozoliņa; Kloviņš, Jānis; Skuja, Vita; Krūmiņa, Angelika; Department of Internal Diseases; Department of Infectology
    Background and Objectives: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the new coronavirus that caused the coronavirus disease 2019 (COVID-19) outbreak. Studies have increasingly reported the involvement of organs outside the respiratory system, including the gastrointestinal tract. Data on the association between COVID-19 and ulcerative colitis (UC) are lacking. Materials and Methods: In this one-centre cross-sectional study, 49 patients with UC from the Riga East Clinical University Hospital outpatient clinic were included from June 2021 to December 2021. The patients were divided into two groups according to their history of a confirmed positive or negative COVID-19 status. Data on their lifestyle, diet, and medications and the food supplements used by the patients were collected during interviews and analysed using the R 4.2.1 software. Results: Out of 49 patients, 33 (63.3%) were male and 13 (36.7%) were female, with a mean age of 32.33 ± 8.6 years. Fourteen patients (28.6%) had a confirmed COVID-19 infection in the last year. The most common COVID-19-related symptoms were a fever and rhinorrhoea. A third of patients followed the inflammatory bowel disease diet (16; 32.7%); out of these patients, 12 (34.3%) did not contract COVID-19 (OR: 0.78 (0.18; 2.98), p > 0.05). In the COVID-19-positive group, the majority of patients did not use vitamin D (11; 79% vs. 3; 21%, (OR: 0.38 (0.07; 1.51), p = 0.28) or probiotics (11; 78.6% vs. 3; 21.4%, OR: 1.33 (0.23; 6.28), p = 0.7). In the COVID-19-positive group, most patients did not smoke (12; 85.7% vs. 2; 14.3%, p = 0.475) and did not use alcohol (9; 64.3% vs. 5; 35.7%, OR: 0.63 (0.16; 2.57), p = 0.5). Most of the patients who participated in sports activities were COVID-negative (18; 51.4% vs. 6; 42.9%, p = 0.82). Conclusions: There were no statistically significant differences in the use of food supplements, probiotics, or vitamins; the lifestyle habits; or the COVID-19 status in patients with UC.
  • No Thumbnail Available
    Item
    Gut Microbiome Differences Regarding Lifestyle and the History of COVID-19 Disease in Ulcerative Colitis Patients
    (2024-08) Straume, Zane; Krūmiņa, Nikola; Elbere, Ilze; Rozenberga, Maija; Blomniece, Laura; Erts, Renārs; Rudzīte, Dace; Kloviņš, Jānis; Krūmiņa, Angelika; Department of Internal Diseases; Department of Infectology
    The microbiome's role in ulcerative colitis pathogenesis is established. The influence of lifestyle on gut microbiome composition remains unclear, and interplay with COVID-19 disease warrants investigation. In a cross-sectional study conducted from June to December 2021, 49 outpatients from Rîga East Clinical University Hospital were included. Patients were categorised based on COVID-19 disease status (positive vs. negative) within the preceding six months. Lifestyle factors (smoking, alcohol consumption, physical activity, stress levels, and dietary patterns) were assessed and evaluated. Taxonomic classification of gut microbiome metagenome data was performed using MetaPhlAn v.2.6.0, with subsequent analysis conducted using SPSS 20.0. Thirty-one (63%) were male, and 18 (37%) were female patients. Fourteen patients (28.6%) tested positive for COVID-19. Gut microbiome composition differences were not observed between COVID-19 disease groups. Twenty-four (49%) patients engaged in sports activities and 30 (61.2%) patients reported a history of smoking. No significant microbiome differences were observed in groups regarding physical activity or smoking. Thirty-five (71.4%) were alcohol users, for whom Firmicutes abundance was significantly higher compared to non-users, p = 0.041. Patients reporting lower stress levels (18, 36.7%) exhibited higher Actinobacteria abundance compared to those with higher stress levels (31, 63.3%), p = 0.03. COVID-19 disease status did not affect gut microbiome composition, alcohol consumption and stress levels demonstrated significant associations.
  • No Thumbnail Available
    Item
    Quality of Life in Patients with Ulcerative Colitis During the Covid-19 Outbreak : A Cross-Sectional Study in a Single Centre in Latvia
    (2024-08-01) Straume, Zane; Krūmiņa, Nikola; Elbere, Ilze; Rozenberga, Maija; Blomniece, Laura; Erts, Renārs; Rudzīte, Dace; Kloviņš, Jānis; Krūmiņa, Angelika; Department of Internal Diseases; Department of Infectology
    Patients with ulcerative colitis (UC), also known as inflammatory bowel disease (IBD), have a higher risk of anxiety and depression compared to healthy individuals. Therefore, it is important to investigate whether the COVID-19 outbreak influenced inflammatory bowel disease-specific quality of life. In total 49 ulcerative colitis (UC) outpatients from Rîga East Clinical University Hospital were included in a cross-sectional study from June to December 2021. The patients were divided according to COVID-19 status (COVID-19 positive vs COVID-19 negative) in the last six months. Patients were interviewed and data from the Short Inflammatory Bowel Disease Questionnaire (SIBDQ), questionnaire about daily life aspects and subjective health evaluation score were collected. Of the 49 patients, 33 (63.3%) were males and 13 (36.7%) were females; median age was 38.0 (IQR = 17) years. Fourteen patients (28.6%) were COVID-19+ within the last six months. The median SIBDQ score was 62 (IQR = 11), for men 63 (IQR = 7.5) and women 58 [(IQR = 13.8), p > 0.05. SIBDQ score was 63 (IQR = 10) for COVID-19 negative and 60 (IQR = 15.6), p > 0.05 for positive patients. Sleep was not influenced by gender, p = 0.008. Three (16.7%) female patients reported a great negative impact on working stability (p = 0.044) and a slightly negative influence on income (p = 0.039). The COVID-19 outbreak may have an influence on daily life aspects by predisposing females more negatively.
  • No Thumbnail Available
    Item
    T-Cell lymphoma misdiagnosed as Crohn's disease : Case report
    (2020) Straume, Zane; Māliņa, Justīne; Proskurina, Anna; Nazarovs, Jurijs; Derovs, Aleksejs; Dubois, Patrick; Rīga Stradiņš University
    For many years, there has been a concern that inflammatory bowel disease carries an increased lymphoma risk. At the same time, patients with intestinal lymphomas are occasionally misdiagnosed as having Crohn's disease. We report a case of T-cell lymphoma of the bowel misdiagnosed as Crohn's disease, which illustrates the diagnostic challenges posed by peripheral extranodal lymphomas. A 68-year old female presented with clinical symptoms (diarrhoea, abdominal pain, poor appetite and significant weight loss), and colonoscopic and initial histological findings that were similar to inflammatory bowel disease. She was diagnosed with Crohn's disease and received treatment with sulfasalazine with subsequent improvement of symptoms. Eight months after the initial diagnosis the patient experienced sudden abdominal pain. Laparotomy revealed necrosis in the small and large intestine and ileostomy was performed. On day 10 of a complicated postoperative period the patient died. Post-mortem histopathological examination of small and large intestine revealed highly malignant peripheral T-cell lymphoma, not otherwise specified. Differentiation of intestinal T-cell lymphoma from Crohn's disease continues to be a challenge, because clinical, colonoscopic, radiological and histopathological findings can mimic Crohn's disease. Careful multi-disciplinary assessment and knowledge of this rare disorder is crucial for timely diagnosis.
  • No Thumbnail Available
    Item
    Острая почечная недостаточность у детей с врожденными пороками сердца после их хирургической коррекции с искуственным кровообращением
    (2014) Krastiņš, Jēkabs; Straume, Zane; Auziņš, Jānis; Pētersons, Aigars; Pētersons, Aivars; Department of Paediatric Surgery; Department of Internal Diseases
    The article presents the research based on data of 30 children with congenital heart disease. The mean age of the patients was 7 months. It was shown that open cardiac surgery caused an expressed but transitory expression of renal biomarkers, creatinine clearance and serum creatinine level. The frequency of occurrences of acute renal failure was 46.6%. Both biomarkers returned to normal values before discharge from the hospital.