Browsing by Author "Sokolova, Marina"

Now showing 1 - 3 of 3
  • No Thumbnail Available
    Item
    Antibacterial Efficiency of Hydroxyapatite Biomaterials with Biodegradable Polylactic Acid and Polycaprolactone Polymers Saturated with Antibiotics
    (2016-08-01) Kroiča, Juta; Skadiņš, Ingus; Salma, Ilze; Reinis, Aigars; Sokolova, Marina; Rostoka, Dagnija; Berza, Natalija; Department of Biology and Microbiology
    Infections continue to spread in all fields of medicine, and especially in the field of implant biomaterial surgery, and not only during the surgery, but also after surgery. Reducing the adhesion of bacteria could decrease the possibility of biomaterial-associated infections. Bacterial adhesion could be reduced by local antibiotic release from the biomaterial. In this in vitro study, hydroxyapatite biomaterials with antibiotics and biodegradable polymers were tested for their ability to reduce bacteria adhesion and biofilm development. This study examined the antibacterial efficiency of hydroxyapatite biomaterials with antibiotics and biodegradable polymers against Staphylococcus epidermidis and Pseudomonas aeruginosa. The study found that hydroxyapatite biomaterials with antibiotics and biodegradable polymers show longer antibacterial properties than hydroxyapatite biomaterials with antibiotics against both bacterial cultures. Therefore, the results of this study demonstrated that biomaterials that are coated with biodegradable polymers release antibiotics from biomaterial samples for a longer period of time and may be useful for reducing bacterial adhesion on orthopedic implants.
  • No Thumbnail Available
    Item
    Influence of antibiotic-impregnated biomaterials on inflammatory cytokines
    (2019) Skadiņš, Ingus; Kroiča, Juta; Šalma, Ilze; Reinis, Aigars; Sokolova, Marina; Rostoka, Dagnija; Department of Biology and Microbiology; Department of Oral and Maxillofacial Surgery and Oral Medicine
  • No Thumbnail Available
    Item
    Mechanical Properties and Biocompatibility of a Biomaterial Based on Deproteinized Hydroxyapatite and Endodentine Cement
    (2016-05-01) Rupeks, Lauris; Filipenkovs, Viktors; Knēts, Ivars; Vītiņš, Visvaldis; Sokolova, Marina; Stīpniece, Līga; Pilmane, Māra; Rīga Stradiņš University
    Hydroxyapatite is used for bone reconstruction, in order to improve its mechanical properties different substances can be added. In our study new biomaterial is created from deproteinised hydroxyaptite and endodentic cement, its mechanical properties were tested. Material was implanted subcutaneous in rats, then histological and biocompatability tests were performed. Results indicate that stuff has good mechanical properties, short setting time and gradual resorption creating porosity and ability to integrate in bone.