Browsing by Author "Plinta, Aelita"

Now showing 1 - 4 of 4
  • No Thumbnail Available
    Item
    Association of Body Mass Index, Blood Pressure and Interictal Serum Levels of Cytokines in Migraine with and without Aura
    (2022) Tretjakovs, Pēteris; Plinta, Aelita; Svirskis, Šimons; Logina, Ināra; Gersone, Gita; Jurka, Antra; Mikelsone, Indra; Blumfelds, Leons; Mackēvičs, Vitolds; Bahs, Guntis; Faculty of Medicine
  • No Thumbnail Available
    Item
    Association of Body Mass Index, Blood Pressure, and Interictal Serum Levels of Cytokines in Migraine with and without Aura
    (2022-10) Plinta, Aelita; Tretjakovs, Pēteris; Svirskis, Šimons; Logina, Ināra; Gersone, Gita; Jurka, Antra; Mikelsone, Indra; Blumfelds, Leons; Mackēvičs, Vitolds; Bahs, Guntis; Faculty of Medicine
    The aim of the study was to clarify correlations between body mass index (BMI), blood pressure (BP), and serum levels of cytokines in female migraine patients. A total of 14 migraineurs with aura, and 12 without aura during their interictal period were compared with 25 controls. Interleukin-8 (IL-8), soluble intercellular adhesion molecule-1 (sICAM-1), soluble vascular cell adhesion molecule-1 (sVCAM-1), matrix metalloproteinase-9 (MMP-9), interferon gamma (IFN-γ), monocyte chemoattractant protein-1 (MCP-1), transforming growth factor alpha (TGF-α), and plasminogen activator inhibitor-1 (PAI-1) were measured. Migraineurs have elevated levels of IL-8, but decreased serum levels of PAI-1 and sICAM-1 during the interictal period, regardless of aura. BMI correlates with BP, and also with IFN-γ and MMP-9 only in patients with aura. There are three correlations in migraine patients with aura that are absent in patients without aura: between IL-8 and PAI-1; MMP-9 and IL-8; and IL-8 and sICAM-1. Migraineurs without aura, on the other hand, have correlations that patients with aura do not have (between PAI-1 and MCP-1, sICAM-1; between MMP-9 and sICAM-1, MCP-1; between TGF-α and PAI-1, MMP-9, sICAM-1; between sICAM-1 and MMP-9, PAI-1, MCP-1; as well as between sVCAM-1 and MCP-1). PAI-1, TGF, and MMP-9 could be used as biomarkers to distinguish migraineurs from healthy individuals.
  • No Thumbnail Available
    Item
    Body Mass Index, Blood Pressure and Interictal Serum Levels of Cytokines in Migraine with and without Aura
    (2023-10) Tretjakovs, Pēteris; Plinta, Aelita; Svirskis, Šimons; Logina, Ināra; Gersone, Gita; Jurka, Antra; Miķelsone, Indra; Blumfelds, Leons; Mackēvičs, Vitolds; Bahs, Guntis; Faculty of Medicine
  • No Thumbnail Available
    Item
    Influence of Migraine on Axon Reflex-Mediated and Endothelial-Dependent Vasodilatation in the Skin
    (2021-06-01) Plinta, Aelita; Tretjakovs, Peteris; Logina, Inara; Miķelsone, Indra; Blumfelds, Leons; Bahs, Guntis; Rīga Stradiņš University
    The aim of the study was to evaluate the changes in skin blood flow as a result of local heating tests in migraine patients during the interictal period, measured by laser Doppler perfusion imaging (LDI). The aim of the study was also to estimate the correlations between the results of these tests and interleukin (IL)-8 levels. Twelve migraine patients during their interictal period were compared with twelve healthy control subjects. Only women were included in the study. Both groups were matched with regard of their age, body mass index and blood pressure. For the purpose of measuring cutaneous microvascular blood flow, heating (+44 °C) of the dorsal side of the palm as a response to the local LDI was used. IL-8 was measured in serum by ELISA method. The findings suggested that migraine patients have a cutaneous vasomotor dysfunction during the interictal period. The results showed a significant decrease in the initial peak of vasodilation and the second peak of vasodilation (plateau phase). Also there were significant changes observed in the length of the time interval required to reach the first and second vasodilation peak. It is known that migraine patients have a shorter time interval to reach the first perfusion peak (axonal reflex-mediated) and longer time interval to reach the second peak (endothelium-dependent). The results confirmed the correlation between proinflammatory chemokine IL-8 levels, and the time interval till the second peak of blood flow in all study subjects.