Browsing by Author "Pahomova, Natalija"

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    Limbs joint position sense in patients with chronic non-specific back pain
    (EDP Sciences, 2018) Pahomova, Natalija; Smite, Daina; Berķis, Uldis; Vilka, Lolita; Rīga Stradiņš University
    To analyze limbs joint positions’ sense and its relationship with pain intensity and duration in patients with chronic non-specific back pain. Methods: Study design: cross-sectional study. For assessment of patients, the following elements were used: general data collection protocol; evaluation of pain intensity using the Visual Analogue Scale; assessment of limb kinesthesia: determination of reposition precision of a 90-degree flexion angle in shoulder, elbow, hip and knee joints. Subjects. The study included 100 patients (88 women, 12 men) with chronic nonspecific back pain, who met the selection criteria for the study. The average age of patients was 45.9 ± 11.6 years, and it ranged from 19 to 64 years. Results: All participants of the study were found to have diminished upper and lower limbs kinesthesia. The study results showed plausible (p < 0.05) relation between limbs kinesthesia and pain intensity and duration, and these correlations were significantly determined by pain localization. Conclusion: Limb kinesthesia is plausibly related to the manifestation of pain in patients with chronic non-specific back pain.
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    Oxidative stress, depression, and risk of recurrence of stable coronary heart disease
    (2021) Ivascenko, Tarass; Voicehovskis, Vladimirs V.; Voicehovska, Julija G.; Skesters, Andrejs; Apsite, Ketija; Grigorjeva, Julija; Kivite-Urtane, Anda; Pahomova, Natalija; Kalejs, Oskars; Rīga Stradiņš University
    Aim: The aim of the study was to investigate the relationships between a level of oxidative stress (OS), depression (D) and risk of recurrence of stable coronary heart disease (SCHD). Methods: A retrospective study was conducted on 174 participants, at the age 45+ years: 86 in-patients of the cardiology department with a recurrent SCHD and 88 in-patients of the cardiology department with primary SCHD. The severity of depressive symptoms was assessed using the long 30-item form of Geriatric Depression Scale (GDS), valid Latvian version of GDS-LAT. The blood samples were taken from each patient to measure oxidative stress parameters malondialdehyde (MDA) and glutathione peroxidase (GPx). Results: 83.9% of the sample had high level of MDA. In 72.4% of the sample the GPx level was normal, in 17.8% it was high and in 9.8% low. Slightly more than a half of the patients were experiencing depression (44.3% – mild D and 6.9% – severe D). GPx was found statistically differing between primary and recurrent SCHD (p = 0,003). Patients with both D and high GPx had 10.6 times higher chances of recurrent SHCD compared to those without D and normal GPx (p = patients with present D were experiencing both – high levels of MDA and GPx – more often than responders with no D, but this wasn’t statistically significant [p = 0.51]). Conclusion: In the present study it was found that level of antioxidant (AO) enzyme GPx was significantly higher in depressed patients with recurrent SCHD compared to patients without D and to patients with primary SCHD and patients with both D and high GPx had higher chances of recurrent SCHD compared to those without D and normal GPx. It could be supposed that GPx is a more significant marker of risk of D and recurrence of SCHD. The high level of MDA in most of both (primary and recurrent SCHD) groups patients could evidence that increased OS is a risk factor for CHD in general. Monitoring OS biomarkers seems to be important in the management of SCHD comorbidity with D. Further studies are warranted to confirm these findings.