Browsing by Author "Padberg, Frank"

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    Clinician treatment choices for post-traumatic stress disorder : ambassadors survey of psychiatrists in 39 European countries
    (2024-03-07) Rojnic Kuzman, Martina; Padberg, Frank; Amann, Benedikt L; Schouler-Ocak, Meryam; Bajic, Zarko; Melartin, Tarja; James, Adrian; Beezhold, Julian; Artigue Gómez, Jordi; Arango, Celso; Jendricko, Tihana; Ismayilov, Jamila; Flannery, William; Chumakov, Egor; Başar, Koray; Vahip, Simavi; Dudek, Dominika; Samochowiec, Jerzy; Mihajlovic, Goran; Rota, Fulvia; Stoppe, Gabriela; Dom, Geert; Catthoor, Kirsten; Chkonia, Eka; Heitor Dos Santos, Maria João; Telles, Diogo; Falkai, Peter; Courtet, Philippe; Patarák, Michal; Izakova, Lubomira; Skugarevski, Oleg; Barjaktarov, Stojan; Babic, Dragan; Racetovic, Goran; Fiorillo, Andrea; Carpiniello, Bernardo; Taube, Māris; Melamed, Yuval; Chihai, Jana; Cozman, Doina Constanta Maria; Mohr, Pavel; Szekeres, György; Delic, Mirjana; Mazaliauskienė, Ramunė; Tomcuk, Aleksandar; Maruta, Nataliya; Gorwood, Philip; Department of Psychiatry and Narcology
    BACKGROUND: Considering the recently growing number of potentially traumatic events in Europe, the European Psychiatric Association undertook a study to investigate clinicians' treatment choices for post-traumatic stress disorder (PTSD). METHODS: The case-based analysis included 611 participants, who correctly classified the vignette as a case of PTSD, from Central/ Eastern Europe (CEE) (n = 279), Southern Europe (SE) (n = 92), Northern Europe (NE) (n = 92), and Western Europe (WE) (N = 148). RESULTS: About 82% woulduse antidepressants (sertraline being the most preferred one). Benzodiazepines and antipsychotics were significantly more frequently recommended by participants from CEE (33 and 4%, respectively), compared to participants from NE (11 and 0%) and SE (9% and 3%). About 52% of clinicians recommended trauma-focused cognitive behavior therapy and 35% psychoeducation, irrespective of their origin. In the latent class analysis, we identified four distinct "profiles" of clinicians. In Class 1 (N = 367), psychiatrists would less often recommend any antidepressants. In Class 2 (N = 51), clinicians would recommend trazodone and prolonged exposure therapy. In Class 3 (N = 65), they propose mirtazapine and eye movement desensitization reprocessing therapy. In Class 4 (N = 128), clinicians propose different types of medications and cognitive processing therapy. About 50.1% of participants in each region stated they do not adhere to recognized treatment guidelines. CONCLUSIONS: Clinicians' decisions for PTSD are broadly similar among European psychiatrists, but regional differences suggest the need for more dialogue and education to harmonize practice across Europe and promote the use of guidelines.
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    Examining the synergistic effects of a cognitive control video game and a home-based, self-administered non-invasive brain stimulation on alleviating depression : the DiSCoVeR trial protocol
    (2023-02) Dechantsreiter, Esther; Padberg, Frank; Morash, Alon; Kumpf, Ulrike; Nguyen, Arthur; Menestrina, Zeno; Windel, Fabienne; Burkhardt, Gerrit; Goerigk, Stephan; Morishita, Takuya; Soldini, Aldo; Ahissar, Shira; Cohen, Tamar; Pasqualotto, Angela; Rubene, Linda; Konosonoka, Liene; Keeser, Daniel; Zill, Peter; Assi, Razan; Gardier, Rémy; Viñals, Roser; Thiran, Jean-Philippe; Segman, Ronen; Benjamini, Yuval; Bonne, Omer; Hummel, Friedhelm Christoph; Bavelier, Daphne; Rancans, Elmars; Nahum, Mor; Department of Psychiatry and Narcology
    Enhanced behavioral interventions are gaining increasing interest as innovative treatment strategies for major depressive disorder (MDD). In this study protocol, we propose to examine the synergistic effects of a self-administered home-treatment, encompassing transcranial direct current stimulation (tDCS) along with a video game based training of attentional control. The study is designed as a two-arm, double-blind, randomized and placebo-controlled multi-center trial (ClinicalTrials.gov: NCT04953208). At three study sites (Israel, Latvia, and Germany), 114 patients with a primary diagnosis of MDD undergo 6 weeks of intervention (30 × 30 min sessions). Patients assigned to the intervention group receive active tDCS (anode F3 and cathode F4; 2 mA intensity) and an action-like video game, while those assigned to the control group receive sham tDCS along with a control video game. An electrode-positioning algorithm is used to standardize tDCS electrode positioning. Participants perform their designated treatment at the clinical center (sessions 1-5) and continue treatment at home under remote supervision (sessions 6-30). The endpoints are feasibility (primary) and safety, treatment efficacy (secondary, i.e., change of Montgomery-Åsberg Depression Rating Scale (MADRS) scores at week six from baseline, clinical response and remission, measures of social, occupational, and psychological functioning, quality of life, and cognitive control (tertiary). Demonstrating the feasibility, safety, and efficacy of this novel combined intervention could expand the range of available treatments for MDD to neuromodulation enhanced interventions providing cost-effective, easily accessible, and low-risk treatment options.ClinicalTrials.gov: NCT04953208.