Browsing by Author "Lurins, Juris"

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    Increased serum chemerin level to predict early onset of aortic valve stenosis
    (2018-01) Lurins, Juris; Lurina, Dace; Tretjakovs, Peteris; Mackevics, Vitolds; Lejnieks, Aivars; Rapisarda, Venerando; Baylon, Vincenzo; Department of Human Physiology and Biochemistry; Department of Internal Diseases
    Inflammation appears to be the cause of aortic valve (AoV) stenosis and identification of predictive biomarkers is therefore imperative. The aim of the current study was to evaluate the potential role of serum chemerin and fibroblast growth factor-21 (FGF-21) in the pathogenesis of the disease. A total of 102 patients were selected based on certain criteria and divided into an aortic stenosis group and a control group. Patients with AoV stenosis were subdivided into three groups depending on the severity according to the echocardiography criteria: Aortic jet velocity, Vmax (m/ sec); mean pressure gradient, PG (mmHg); aortic valve area (AVA), cm2; and indexed AVA, cm2/m2. Patients were graded as: Severe: Vmax >4 m/sec, PG >40 mmHg, AVA <1.0 cm2, indexed AVA <0.6; moderate: Vmax 3.0-4.0 m/sec, PG 20-40 mmHg, AVA 1.0-1.5 cm2, indexed AVA 0.60-0.85; mild: Vmax 2.5-2.9 m/sec, PG <20 mmHg, AVA >1.5 cm2, indexed AVA >0.85. ELISA was used for the detection of chemerin and FGF-21. Post-hoc analysis with Tukey's correction was performed. The highest chemerin levels were found in mild and moderate AoV stenosis and decreased along with the grade of severity, compared with the control group. The FGF-21 level was increased in all the stenosis groups, reaching the highest level at severe stenosis. Receiver-operating characteristic analysis of chemerin in all the AoV stenosis groups without grading the severity included, area under the curve (AUC)=0.76; 0.70-0.80= fair; P<0.001 and for mild AoV stenosis was AUC=0.82; 0.80-0.90= good; P<0.001. In conclusion, chemerin is a good diagnostic biomarker for mild AoV stenosis, while FGF-21 is a moderate diagnostic marker.
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    Thioredoxin‐1 and correlations of the plasma cytokines regarding aortic valve stenosis severity
    (2021-08-18) Tretjakovs, Peteris; Lurins, Juris; Svirskis, Simons; Gersone, Gita; Lurina, Dace; Rozenberga, Ulla; Blumfelds, Leons; Bahs, Guntis; Lejnieks, Aivars; Mackevics, Vitolds; Faculty of Medicine
    Aortic valve stenosis (AS) develops not only with a pronounced local inflammatory re-sponse, but also oxidative stress is involved. The aim of this study was to evaluate the plasma levels of thioredoxin‐1 (TRX1), myeloperoxidase (MPO), chemerin, growth differentiation factor 15 (GDF‐ 15), angiopoietin‐2 (Ang‐2), vascular endothelial growth factor A (VEGF‐A), fibroblast growth factor 2 (FGF‐2), fibroblast growth factor 21 (FGF‐21), and metalloproteinase (MMP)‐1, ‐3, and ‐9 in acquired AS patients as well as to clarify the correlations of TXR1 and the plasma inflammatory biomarkers regarding AS severity. AS patients were classified into three groups: 16 patients with mild AS stenosis, 19 with moderate and 11 with severe AS, and 30 subjects without AS were selected as a control group. AS patients had significantly higher plasma levels of TRX1 compared to controls, but the highest difference was found in mild AS patients compared to the controls. We conclude that AS is associated with significantly increased plasma TRX1 levels, and TRX1 might serve as a specific and sensitive biomarker of AS. TRX1 and also chemerin, GDF‐15, VEGF‐A, FGF‐2 and FGF‐ 21 significantly correlate with AS severity degrees. TRX1 also showed positive association with FGF‐2, VEGF‐A, and MMP‐3 in all AS patients.