Browsing by Author "Lansiaux, Edouard"

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    Group A streptococcal (GAS) infections amongst children in Europe : Taming the rising tide
    (2023-01) Jain, Nityanand; Lansiaux, Edouard; Reinis, Aigars; Faculty of Medicine
    A rising tide of Group A streptococcal infections is being reported in several European countries including the UK, Spain, Sweden, France, and Ireland. In this editorial, we shed light on the current scenario and present the discussion on the latest available interim clinical guidelines. We further explore the cause of this sudden rise and the interventional measures needed to tame the rising tide.
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    The new face of monkeypox virus : an emerging global emergency
    (2022-05-27) Jain, Nityanand; Lansiaux, Edouard; Simanis, Raimonds; Faculty of Medicine; Department of Infectology
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    Understanding the complexities of space anaemia in extended space missions : revelations from microgravitational odyssey
    (2024-03-11) Lansiaux, Edouard; Jain, Nityanand; Yatin chodnekar, Swarali; Siddiq, Abdelmomen; Ibrahim, Muiz; Yèche, Mathieu; Kantane, Inara; Statistics Unit
    Space travel exposes astronauts to several environmental challenges, including microgravity and radiation exposure. To overcome these stressors, the body undergoes various adaptations such as cardiovascular deconditioning, fluid shifts, metabolic changes, and alterations in the state of the bone marrow. Another area of concern is the potential impact of these adaptations on erythrocyte and haemoglobin concentrations, which can lead to what is commonly referred to as space anaemia or microgravity-induced anaemia. It is known that anaemia may result in impaired physical and cognitive performance, making early detection and management crucial for the health and wellbeing of astronauts during extended space missions. However, the effects and mechanisms of space anaemia are not fully understood, and research is underway to determine the extent to which it poses a challenge to astronauts. Further research is needed to clarify the long-term effects of microgravity on the circulatory system and to investigate possible solutions to address spaceflight-induced anaemia. This article reviews the potential link between spaceflight and anaemia, based on existing evidence from simulated studies (e.g., microgravity and radiation studies) and findings from spaceflight studies (e.g., International Space Station and space shuttle missions).
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    The virology of human monkeypox virus (hMPXV) : A brief overview
    (2022-12) Lansiaux, Edouard; Jain, Nityanand; Laivacuma, Sniedze; Reinis, Aigars; Faculty of Medicine; Department of Infectology; Department of Biology and Microbiology
    First described in 1958, the human monkeypox virus (hMPXV) is a neglected zoonotic pathogen closely associated with the smallpox virus. The virus usually spreads via close contact with the infected animal or human and has been endemic mostly in parts of the African continent. However, with the recent increase in trade, tourism, and travel, the virus has caused outbreaks in countries outside Africa. The recent outbreak in 2022 has been puzzling given the lack of epidemiological connection and the possible sexual transmission of the virus. Furthermore, there is limited understanding of the structural and pathogenetic mechanisms that are employed by the virus to invade the host cells. Henceforth, it is critical to understand the working apparatus governing the viral-immune interactions to develop effective therapeutical and prophylactic modalities. Hence, in the present short communication, we summarize the previously reported research findings regarding the virology of the human monkeypox virus.