Browsing by Author "Lagzdiņa, Rudīte"
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Item Circulating Levels of IL-8 and MCP-1 in Healthy Adults : Changes after an Acute Aerobic Exercise and Association with Body Composition and Energy Metabolism(2023-10) Lagzdiņa, Rudīte; Rumaka, Maija; Gersone, Gita; Tretjakovs, Pēteris; Department of Human Physiology and BiochemistryThe most recent WHO recommendations about physical activity emphasise the importance of total exercise volume above the significance of the duration of each bout. This study examined whether acute aerobic exercise changes circulating levels of IL-8 and MCP-1 and if these changes are associated with body composition and energy metabolism. Healthy adult volunteers completed a 10 min walking–running exercise on a treadmill. Indirect calorimetry was used to determine their resting metabolic rate (RMR) and energy expenditure (EE) during the exercise. Pre-exercise levels of IL-8 and MCP-1 were similar in both sexes. There were positive correlations of pre-exercise IL-8 with body mass, waist circumference, and lean body mass in men and pre-exercise MCP-1 with RMR in women. The exercise led to an increase in IL-8 of 68% and a decrease in MCP-1 of 74% of participants. An increase in post-exercise IL-8 in men was associated with greater walking EE and a greater increase in walking EE. The increase in post-exercise MCP-1 was associated with a lower RMR and running EE in women. There are both sex and individual variations in changes in chemokine secretion in response to the same exercise situation and their associations with values of metabolic parameters.Item Habitual physical activity pattern and its association with gender and body composition in healthy adults(2019-01-04) Lagzdiņa, Rudīte; Rumaka, Maija; Department of Human Physiology and BiochemistryAn appropriate level of physical activity (PA) is beneficial for health and weight management. This study examines the relationship of habitual PA and activity energy expenditure (AEE) in a typical week with gender and body composition parameters. Data of habitual PA of 72 healthy adults were collected with the heart rate and motion sensor (Actiheart). Total and segmental body fat was measured with bioelectrical impedance analyser. Men were more active in total and on working days and had shorter light and longer moderate and vigorous PA on working days than females (p<0.05). Females had less inactive and sitting time on days off. Inactive and sitting time in working days for both genders correlated positively with visceral fat rating, body and leg fat % (p<0.05). In male’s duration of working days’ moderate PA correlated inversely, but light PA positively with these parameters (p<0.05). Males with more vigorous PA in working day and AEE in days off had lower body fat % (p<0.05). A distinctive PA pattern on working days and days off indicates a gender-related differences. Decrease of time of inactivity and light PA and increase of duration of moderate and vigorous PA was associated with lower body and segmental fat amountItem Pharmacological properties of polyphenols : Bioavailability, mechanisms of action and biological effects in in vitro studies, animal models and humans(2021-08) Stromsnes, Kristine; Lagzdiņa, Rudīte; Olaso‐Gonzalez, Gloria; Gimeno‐Mallench, Lucia; Gambini, Juan; Department of Human Physiology and BiochemistryDrugs are bioactive compounds originally discovered from chemical structures present in both the plant and animal kingdoms. These have the ability to interact with molecules found in our body, blocking them, activating them, or increasing or decreasing their levels. Their actions have allowed us to cure diseases and improve our state of health, which has led us to increase the longevity of our species. Among the molecules with pharmacological activity produced by plants are the polyphenols. These, due to their molecular structure, as drugs, also have the ability to interact with molecules in our body, presenting various pharmacological properties. In addition, these compounds are found in multiple foods in our diet. In this review, we focused on discussing the bioavailability of these compounds when we ingested them through diet and the specific mechanisms of action of polyphenols, focusing on studies carried out in vitro, in animals and in humans over the last five years. Knowing which foods have these pharmacological activities could allow us to prevent and aid as concomitant treatment against various pathologies.Item Physical Activity Habits of Latvian Nursing Students : A Cross-Sectional Study(2022-12) Veseta, Una; Lagzdiņa, Rudīte; Rumaka, Maija; Reide, Lāsma; Arnis, Voldemārs; Kampara, Mara; Vīnberga, Indra; Upeniece, Irēna; Zolovs, Maksims; Department of Sports and Nutrition; Department of Human Physiology and Biochemistry; Statistics UnitIt is important to integrate knowledge about the need for physical activities (PA) in the prevention and care of human health in nursing study programs so that nurses can promote PA among their patients. This study aims to evaluate the PA habits of Latvian nursing students. Participants were students of three universities in Latvia who were enrolled in a four-year bachelor study program, “Nursing”, with a total of 341 after the data cleaning (population size n = 1554). The questionnaire contained questions about sociodemographic variables derived from the survey of the Centre for Disease Prevention and Control of Latvia “Health Behaviour among Latvian Adult Population”, habits of PA, and International Physical Activity Questionnaire-Short Form. The data were collected between September and November 2021. Both descriptive and inferential statistics (difference between groups, correlation, and association tests) were calculated to analyse the data. Of the study population, 39% did not reach the minimum WHO-recommended PA. Increased PA level in the later study years is related to more frequent engagement in work and fewer table activities in the curriculum study process, but the higher intensity and total PA could be related to the specifics of nurse and nurse assistant work, which could be especially intense due to the overloaded health care system during the COVID-19 pandemic.Item Physical activity in healthy urban adults and its association with body composition parameters(EDP Sciences, 2019-11-25) Lagzdiņa, Rudīte; Rumaka, Maija; Berķis, Uldis; Vilka, Lolita; Department of Human Physiology and BiochemistryAn adequate amount of physical activity (PA) in adults improves cardio-respiratory fitness, metabolic health and helps maintain a normal body weight and composition. Here we examined sex- and occupation-related PA patterns and their association with body composition parameters. Healthy volunteers (n = 97) aged 21–49 years completed a self-administered PA questionnaire and characterized their occupational duties depending on the volume of the physical work involved. A bio-impedance analyser was used to determine body composition. Men reported more metabolic equivalent of task (MET) minutes/week of vigorous PA than women (p < 0.05). Participants with low occupational PA had less walking, moderate and total MET minutes/week, and more sitting time than those with moderate and vigorous occupational PA (p < 0.05), but their body composition parameters did not differ. In males, negative correlations were found between body fat percentage, visceral fat range, segmental fat mass, and moderate MET minutes/week, whereas positive associations were observed between muscle mass in legs and vigorous MET minutes/week (p<0.05). In females, negative correlations were found between visceral fat and vigorous MET minutes/week but positive – between lean body mass, trunk and leg muscle mass, and moderate PA (p < 0.05). These observed associations might be used to develop interventions to promote sex- and occupation-specific PA.