Browsing by Author "Kalniņa, Marika"

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    Deliverable 5.1 - Questionnaire on industrial and clinical key players and needs (v1.0).
    (2022-09-30) Radzina, Maija; Mamis, Edgars; Saule, Laura; Pajuste, Elīna; Kalniņa, Marika; Cocolios, Thomas; Talip, Zeynep; Stora, Thierry
    This document is a summary of responses received from the public known European industrial manufacturing and research institution and clinical facility representatives. The responses were given to the PRISMAP Consortium questionnaire disseminated in January-August 2022, approaching radionuclides and radiopharmaceutical manufacturers, research institutions and clinical end users in nuclear medicine, with the aim to identify potential stakeholders in the industrial and clinical communities interested by a coordinated approach in Europe such as PRISMAP. The summary from PRISMAP questionnaire stratifies the feedback from 114 respondents: radionuclide and radiopharmaceutical producers, research facilities and preclinical/clinical end users. In addition, it gives an insight into the location and capabilities of the main isotope-producing cyclotron facilities, many of which are known from the IAEA cyclotron database [2]). The questionnaire was offered with an opportunity to make new research and international collaboration partners, where all parties could benefit from harmonised supply and legislation procedures, expanding network and distribution routes, and subsequently gain visibility within the PRISMAP User Forum map at www.prismap.eu. The questionnaire was focused on the radionuclide use in medicine with emphasis on future needs for specific radionuclides and possible research developments with awareness of legislation, logistics and involved personnel education challenges and future perspectives.
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    Ewing Sarcoma of the Lumbar Spine With Lung Metastases in A 20-Year-Old Adult : A Rare Case Report
    (2024-03-12) Balodis, Arturs; Eglīte , Everita; Zarembo, Zane; Raits , Uldis; Dolgopolova, Jūlija; Kalniņa, Marika; Lapse, Daire; Department of Radiology
    Background: Ewing sarcoma (ES), a rare bone tumor primarily affecting adolescents and young adults, exhibits aggressive behavior, typically originating from bones or nearby soft tissues. Histopathology reveals a small round cell tumour, posing a challenge in distinguishing from small cell carcinoma, sarcomas, or lymphoma. This report outlines a 20-year-old man’s case of lumbar spine ES with lung metastases. 1.2. Case Report: A 20-year-old male complained of back pain radiating to both legs, particularly the right. No signs of paralysis were evident. Magnetic Resonance Imaging revealed a lumbar mass with extradural spread in the spinal canal, compressing the dural sac and extending through the intervertebral foramen, auto necrosis areas were identified which led to working diagnosis of Schwannoma. The surgical extraction of the lumbar mass was performed. Immunohistochemical analysis of operative material revealed small round tumour cells with CD99 positivity. Subsequently, a t (11; 22) (q24.3; q12.2) translocation was identified, confirming the histopathological diagnosis of Ewing sarcoma. Two months post-surgery, lung metastases and hypermetabolism in L2 vertebra, spinal cord, and TH11-TH12 tissue were detected. The next step in the patient’s treatment plan involves chemotherapy. 1.3. Conclusion: Ewing’s sarcoma, a fast-growing malignancy, requires a multidisciplinary approach due to its clinical and radiographic features. This report underscores the challenge of distinguishing primary bone Ewing sarcoma from bone metastasis of other small round cell malignancies. The tumour’s unusual location may complicate diagnosis, potentially leading to confusion with schwannoma. Early, precise diagnosis is crucial for prompt treatment