Browsing by Author "Kakar, Jagriti"

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    Analysing Clinical and Demographic Data from a Study on Oral Lichen Planus Patients
    (2024-08-01) Kakar, Jagriti; Sokolovska, Lība; Dabuzinskiene, Anita; Murovska, Modra; Čēma, Ingrīda; Department of Oral and Maxillofacial Surgery and Oral Medicine; Institute of Microbiology and Virology
    Oral lichen planus (OLP) is a common mucocutaneous disorder affecting approximately 1–2% of the population, predominantly middle-aged women. This study aims to analyse the demographic and clinical characteristics of OLP patients treated at the Oral Medicine Centre of Institute of Stomatology, Rīga Stradiņš University. The cohort comprised adult patients diagnosed with OLP, who underwent structured clinical evaluations. The study identified significant patterns in age, gender distribution, clinical forms, and associated discomfort levels. Females constituted 75.76% of the cohort, with a mean age of 60 years. The reticular form of OLP was most prevalent, while the erosive form, associated with considerable discomfort, was more common in females. Treatment regimens varied, with Sol Kenalog 0.2% and Ointment Clobetasol 0.05% being the primary therapies. Sol Kenalog 0.2% was more effective in providing symptom relief and reducing relapse frequency. Chronic diseases and stress were prevalent among patients, complicating management and treatment outcomes. The study emphasises the need for personalised treatment strategies that consider the severity of the clinical form, patient comfort, and comorbid conditions. Further research is recommended to validate these findings and explore the underlying mechanisms of gender differences and the impact of comorbidities on OLP. The insights from this study aim to enhance clinical practices and improve patient outcomes.
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    Immunological Aspects of EBV and Oral Mucosa Interactions in Oral Lichen Planus
    (2023-06-01) Čēma, Ingrīda; Kakar, Jagriti; Dzudzilo, Madara; Murovska, Modra; Department of Oral and Maxillofacial Surgery and Oral Medicine; Department of Doctoral Studies; Institute of Microbiology and Virology
    Oral lichen planus (OLP) is considered a T cell-mediated chronic inflammatory process activated by an unknown antigen, making basal keratinocytes vulnerable to a cytotoxic cell mediated immune response. The aim of this review is to summarize information on the role and pathways of Epstein–Barr virus (EBV) and immune cells in inducing OLP as an autoimmune lesion. The pathogenesis of OLP is analyzed from immunological aspects of interactions between EBV and oral mucosa. The results of the available studies allow us to assume that EBV can act both as an exogenous and an endogenous antigen in the pathogenesis of OLP. We emphasized the role of antigen-presenting cells (APC), such as dendritic cells (Langerhans cells, LC), in detecting and capturing antigens and modulating the adaptive immune response. Although EBV shows tropism for B cells and epithelial cells, under certain conditions it can infect monocytes, LCs, NK, and T lymphocytes. It means that under some circumstances of the chronic inflammatory process, EBV particles can react as endogenous agents. During the development of the autoimmune process, a decisive role is played by the loss of immune tolerance. Factors like the activity of cytokines, chemokines, and autoantibodies secreted by EBV-positive plasma cells, autoantigens formed due to virus protein mimicry of human proteins, new self-peptides released from damaged tissues, self-reactive B and T cells, dysregulation of LC function, the anti-apoptotic effect of EBV early lytic antigens, and an imbalance between inflammatory and anti-inflammatory immune cells facilitate the development of an autoimmune process.