Browsing by Author "Godderis, Lode"

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    Harmonized definition of occupational burnout : A systematic review, semantic analysis, and Delphi consensus in 29 countries
    (2021-03-01) Guseva Canu, Irina; Marca, Sandy Carla; Dell'Oro, Francesca; Balázs, Ádám; Bergamaschi, Enrico; Besse, Christine; Bianchi, Renzo; Bislimovska, Jovanka; Koscec Bjelajac, Adrijana; Bugge, Merete; Busneag, Carmen Iliana; Çağlayan, Çiğdem; Cernițanu, Mariana; Costa Pereira, Cristiana; Dernovšček Hafner, Nataša; Droz, Nadia; Eglite, Maija; Godderis, Lode; Gündel, Harald; Hakanen, Jari J; Iordache, Raluca Maria; Khireddine-Medouni, Imane; Kiran, Sibel; Larese-Filon, Francesca; Lazor-Blanchet, Catherine; Légeron, Patrick; Loney, Tom; Majery, Nicole; Merisalu, Eda; Mehlum, Ingrid Sivesind; Michaud, Laurent; Mijakoski, Dragan; Minov, Jordan; Modenese, Alberto; Molan, Marija; van der Molen, Henk; Nena, Evangelia; Nolimal, Dusan; Otelea, Marina; Pletea, Elisabeta; Pranjic, Nurka; Rebergen, David; Reste, Jelena; Schernhammer, Eva; Wahlen, Anny; Department of Occupational and Environmental Medicine; Institute of Occupational Safety and Environmental Health
    Objective A consensual definition of occupational burnout is currently lacking. We aimed to harmonize the definition of occupational burnout as a health outcome in medical research and reach a consensus on this definition within the Network on the Coordination and Harmonisation of European Occupational Cohorts (OMEGA-NET). Methods First, we performed a systematic review in MEDLINE, PsycINFO and Embase (January 1990 to August 2018) and a semantic analysis of the available definitions. We used the definitions of burnout and burnout-related concepts from the Systematized Nomenclature of Medicine Clinical Terms (SNOMED-CT) to formulate a consistent harmonized definition of the concept. Second, we sought to obtain the Delphi consensus on the proposed definition. Results We identified 88 unique definitions of burnout and assigned each of them to 1 of the 11 original definitions. The semantic analysis yielded a first proposal, further reformulated according to SNOMED-CT and the panelists` comments as follows: "In a worker, occupational burnout or occupational physical AND emotional exhaustion state is an exhaustion due to prolonged exposure to work-related problems". A panel of 50 experts (researchers and healthcare professionals with an interest for occupational burnout) reached consensus on this proposal at the second round of the Delphi, with 82% of experts agreeing on it. Conclusion This study resulted in a harmonized definition of occupational burnout approved by experts from 29 countries within OMEGA-NET. Future research should address the reproducibility of the Delphi consensus in a larger panel of experts, representing more countries, and examine the practicability of the definition.
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    HBM4EU E-waste study – An untargeted metabolomics approach to characterize metabolic changes during E-waste recycling
    (2025-02) Kozlowska, Lucyna; Viegas, Susana; Scheepers, Paul T.J.; Duca, Radu C.; Godderis, Lode; Martins, Carla; Ciura, Krzesimir; Jagiello, Karolina; João Silva, Maria; Mahiout, Selma; Mārtiņsone, Inese; Matisāne, Linda; Nieuwenhuyse, An van; Puzyn, Tomasz; Sijko-Szpanska, Monika; Verdonck, Jelle; Santonen, Tiina; the HBM4EU E-waste Study Team; Institute of Occupational Safety and Environmental Health
    E-waste contains hazardous chemicals that may be a direct health risk for workers involved in recycling. We conducted an untargeted metabolomics analysis of urine samples collected from male e-waste processing workers to explore metabolic changes associated with chemical exposures in e-waste recycling in Belgium, Finland, Latvia, Luxembourg, the Netherlands, Poland, and Portugal. Questionnaire data and urine samples were obtained from workers involved in the processing of e-waste (sorting, dismantling, shredding, pre-processing, metal, and non-metal processing), as well as from controls with no known occupational exposure. Pre- and post-shift urine samples were collected and analysed using ultrahigh-performance liquid chromatography-mass spectrometry (UPLC-MS). A total of 32 endogenous urinary metabolites were annotated with a Variable Importance in Projection (VIP) above 2, indicating that e-waste recycling is mainly associated with changes in steroid hormone and neurotransmitter metabolism, energy metabolism, bile acid biosynthesis, and inflammation. The highest VIP was observed for dopamine-o-quinone, which is linked to Parkinson's disease. These and other changes in metabolism in workers employed in the processing of e-waste need further verification in targeted studies.
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    HBM4EU Occupational Biomonitoring Study on e-Waste—Study Protocol
    (2021-12-02) Scheepers, Paul T. J.; Duca, Radu Corneliu; Galea, Karen S.; Godderis, Lode; Hardy, Emilie; Akūlova, Lāsma; Knudsen, Lisbeth E.; Komarovska, Laura; Leese, Elizabeth; Matisāne, Linda; Paegle, Linda; Mārtiņsone, Inese; Seile, Anita; Louro, Henriqueta; Mahiout, Selma; Ndaw, Sophie; Poels, Katrien; Porras, Simo P.; Silva, Maria J.; Tavares, Ana Maria; Verdonck, Jelle; Viegas, Susana; Santonen, Tiina; Rīga Stradiņš University
    Workers involved in the processing of electronic waste (e-waste) are potentially exposed to toxic chemicals. If exposure occurs, this may result in uptake and potential adverse health effects. Thus, exposure surveillance is an important requirement for health risk management and prevention of occupational disease. Human biomonitoring by measurement of specific biomarkers in body fluids is considered as an effective method of exposure surveillance. The aim of this study is to investigate the internal exposure of workers processing e-waste using a human biomonitoring approach, which will stimulate improved work practices and contribute to raising awareness of potential hazards. This exploratory study in occupational exposures in e-waste processing is part of the European Human Biomonitoring Initiative (HBM4EU). Here we present a study protocol using a cross sectional survey design to study worker’s exposures and compare these to the exposure of subjects preferably employed in the same company but with no known exposure to industrial recycling of e-waste. The present study protocol will be applied in six to eight European countries to ensure standardised data collection. The target population size is 300 exposed and 150 controls. Biomarkers of exposure for the following chemicals will be used: chromium, cadmium and lead in blood and urine; brominated flame retardants and polychlorobiphenyls in blood; mercury, organophosphate flame retardants and phthalates in urine, and chromium, cadmium, lead and mercury in hair. In addition, the following effect biomarkers will be studied: micronuclei, epigenetic, oxidative stress, inflammatory markers and telomere length in blood and metabolomics in urine. Occupational hygiene sampling methods (airborne and settled dust, silicon wristbands and handwipes) and contextual information will be collected to facilitate the interpretation of the biomarker results and discuss exposure mitigating interventions to further reduce exposures if needed. This study protocol can be adapted to future European-wide occupational studies