Browsing by Author "Dāvidsone, Zane"
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Item 2016 Classification Criteria for Macrophage Activation Syndrome Complicating Systemic Juvenile Idiopathic Arthritis : A European League Against Rheumatism/American College of Rheumatology/Paediatric Rheumatology International Trials Organisation Collaborative Initiative(2016-03-01) Paediatric Rheumatology International Trials Organisation, the Childhood Arthritis andRheumatology Research Alliance, the Pediatric Rheumatology Collaborative Study Group,and the Histiocyte Societ; Dāvidsone, ZaneObjective To develop criteria for the classification of macrophage activation syndrome (MAS) in patients with systemic juvenile idiopathic arthritis (JIA). Methods A multistep process, based on a combination of expert consensus and analysis of real patient data, was conducted. A panel of 28 experts was first asked to classify 428 patient profiles as having or not having MAS, based on clinical and laboratory features at the time of disease onset. The 428 profiles comprised 161 patients with systemic JIA-associated MAS and 267 patients with a condition that could potentially be confused with MAS (active systemic JIA without evidence of MAS, or systemic infection). Next, the ability of candidate criteria to classify individual patients as having MAS or not having MAS was assessed by evaluating the agreement between the classification yielded using the criteria and the consensus classification of the experts. The final criteria were selected in a consensus conference. Results Experts achieved consensus on the classification of 391 of the 428 patient profiles (91.4%). A total of 982 candidate criteria were tested statistically. The 37 best-performing criteria and 8 criteria obtained from the literature were evaluated at the consensus conference. During the conference, 82% consensus among experts was reached on the final MAS classification criteria. In validation analyses, these criteria had a sensitivity of 0.73 and a specificity of 0.99. Agreement between the classification (MAS or not MAS) obtained using the criteria and the original diagnosis made by the treating physician was high (κ = 0.76). Conclusion We have developed a set of classification criteria for MAS complicating systemic JIA and provided preliminary evidence of its validity. Use of these criteria will potentially improve understanding of MAS in systemic JIA and enhance efforts to discover effective therapies, by ensuring appropriate patient enrollment in studies.Item Children's rights in healthcare : The influence of age on involvement(EDP Sciences, 2024) Popeiko, Poļina; Puķīte, Ieva; Dāvidsone, Zane; Dzīvīte-Krišāne, Iveta; Visnevska, Inta; Gardovska, Dace; Vilka, L.; Krūmiņa, J.; Rīga Stradiņš UniversityThe aim of this article is to highlight the significance of actively involving young children in their own healthcare and paediatric healthcare planning. Based on a study conducted in a hospital setting, which revealed a lack of personalized care and inadequate understanding among younger children, this article discusses the potential benefits of empowering young patients. The theoretical framework explores various dimensions, including child-centred care, communication strategies, child development, and the impact of involving children in decision-making processes. By fostering children’s participation and creating a safe environment, healthcare professionals can enhance the overall quality of care and promote positive health outcomes for young patients.Item Defining Criteria for Disease Activity States in Systemic Juvenile Idiopathic Arthritis Based on the Systemic Juvenile Arthritis Disease Activity Score(2024-09) Rosina, Silvia; Rebollo-Giménez, Ana I; Tarantola, Letizia; Pistorio, Angela; Vyzhga, Yulia; El Miedany, Yasser; Lotfy, Hala M; Abu-Shady, Hend; Eissa, Mervat; Osman, Naglaa S; Hassan, Waleed; Mahgoub, Marwa Y; Fouad, Nermeen A; Mosa, Doaa M; Adel, Yasmin; Mohamed, Sheren E M; Radwan, Ahmed R; Abu-Zaid, Mohamed H; Tabra, Samar A A; Shalaby, Radwa H; Nasef, Samah I; Khubchandani, Raju; Khan, Archana; Maldar, Naziya P; Ozen, Seza; Bayindir, Yagmur; Alsuweiti, Motasem; Alzyoud, Raed; Almaaitah, Hiba; Vilaiyuk, Soamarat; Lerkvaleekul, Butsabong; Alexeeva, Ekaterina; Dvoryakovskaya, Tatyana; Kriulin, Ivan; Bracaglia, Claudia; Pardeo, Manuela; De Benedetti, Fabrizio; Licciardi, Francesco; Montin, Davide; Robasto, Francesca; Minoia, Francesca; Filocamo, Giovanni; Rossano, Martina; Simonini, Gabriele; Marrani, Edoardo; Abu-Rumeileh, Sarah; Kostik, Mikhail M; Belozerov, Konstantin E; Pal, Priyankar; Bathia, Jigna N; Katsicas, María M; Villarreal, Giselle; Marino, Achille; Costi, Stefania; Sztajnbok, Flavio; Silva, Rodrigo M; Maggio, Maria C; El-Ghoneimy, Dalia H; El Owaidy, Rasha; Civino, Adele; Diomeda, Federico; Al-Mayouf, Sulaiman M; Al-Sofyani, Fuad; Dāvidsone, Zane; Patrone, Elisa; Saad-Magalhães, Claudia; Consolaro, Alessandro; Ravelli, AngeloOBJECTIVE: Our objective was to develop and validate cutoff values in the systemic Juvenile Arthritis Disease Activity Score 10 (sJADAS10) that distinguish the states of inactive disease (ID), minimal disease activity (MDA), moderate disease activity (MoDA), and high disease activity (HDA) in children with systemic juvenile idiopathic arthritis, based on subjective disease state assessment by the treating pediatric rheumatologist. METHODS: The cutoff definition cohort was composed of 400 patients enrolled at 30 pediatric rheumatology centers in 11 countries. Using the subjective physician rating as an external criterion, six methods were applied to identify the cutoffs: mapping, calculation of percentiles of cumulative score distribution, the Youden index, 90% specificity, maximum agreement, and receiver operating characteristic curve analysis. Sixty percent of the patients were assigned to the definition cohort, and 40% were assigned to the validation cohort. Cutoff validation was conducted by assessing discriminative ability. RESULTS: The sJADAS10 cutoffs that separated ID from MDA, MDA from MoDA, and MoDA from HDA were ≤2.9, ≤10, and >20.6, respectively. The cutoffs discriminated strongly among different levels of pain, between patients with and without morning stiffness, and among patients whose parents judged their disease status as remission or persistent activity or flare or were satisfied or not satisfied with current illness outcome. CONCLUSION: The sJADAS cutoffs revealed good metrologic properties in both definition and validation cohorts and are therefore suitable for use in clinical trials and routine practice.Item Juvenīla idiopātiska artrīta klīniskās vadlīnijas(Latvijas Pediatru reimatologu biedrība, 2016) Stanevica, Valda; Lazareva, Arina; Šantere, Ruta; Dāvidsone, Zane; Department of PaediatricsItem Kawasaki disease in Latvia 2012–2019 : epidemiology and rate of resistance to initial treatment(2020-11-04) Vasiļevska, Lauma; Dāvidsone, Zane; Ligere, Elīna; Šantere, Ruta; Staņēviča, Valda; Rīga Stradiņš UniversityIntroduction: Kawasaki disease (KD) is an acute febrile illness of early childhood, characterised by vasculitis of the coronary and medium-sized arteries. The incidence of the disease differs worldwide, but the incidence of KD has not been established in Latvia. The aim of the study was to describe the epidemiological characteristics and estimate the incidence rate and resistance to initial treatment of KD among hospitalised children in Latvia. Material and methods: The study was a descriptive, population-based study, which used hospital discharge records of patients < 18 years old diagnosed with KD in the years 2012–2019. Incidence rate was calculated using the number of KD patients and corresponding national census data. Results: There were 36 KD patients in Latvia. The median age at admission was 2.8 years, with 67% of cases under 5 years of age, and the male/female ratio was 1.3 : 1. The mean annual incidence rate was 1.3 per 100,000 children 0–18 years old, and 2.9 per 100,000 for children < 5 years old. The mean length of hospital stay was 14 days. Coronary artery dilatation was recorded in 8% of the patients (all of whom were male). Every patient received intravenous immunoglobulin (IVIG), with a median of 7 days from fever onset to IVIG administration. Refractory treatment was reported in 25% of cases. Conclusions: This is the first epidemiological study of KD in Latvia. The incidence rates are lower than those reported for other European countries. The percentage of refractory treatment was higher than in other studies.Item A novel frameshift variant in the ADA2 gene of a patient with a neurological phenotype : a case report(2022-12) Lucāne, Zane; Dāvidsone, Zane; Micule, Ieva; Auzenbaha, Madara; Kurjāne, Nataļja; Rīga Stradiņš UniversityBackground Adenosine deaminase 2 (ADA2) deficiency is an inherited autoinflammatory syndrome caused by a defect in the ADA2 gene. Most common manifestations include peripheral vasculopathy, early-onset stroke, immunodeficiency, and haematological manifestations. Patients with pathogenic variants that are more detrimental to ADA2’s enzymatic function (e.g. frameshift) have been reported to be prone to developing hematological phenotype. We report here the case of a 13-year-old Caucasian girl with a novel frameshift variant in the ADA2 gene and a clinical phenotype of early-onset stroke. Case presentation The patient was admitted to hospital with complaints of weakness in her right arm, unilateral facial weakness and speech problems. Her initial laboratory workup was normal; however, magnetic resonance imaging of her brain confirmed acute/subacute ischaemic changes in the posterior limb of the left-sided internal capsule and in the apical part of the thalamus. She also had manifestations of immunodeficiency – recurrent skin infections and otitis, chronic Molluscum contagiosum infection in anamnesis and B cell deficiency with a low level of serum IgA. The patient’s DNA was analysed and two pathogenic variants were identified in the ADA2 gene, confirming a diagnosis of adenosine deaminase 2 (ADA2) deficiency. While one of the variants (c.506G > A (p.Arg169Gln)) has been reported previously, the other one is a novel frameshift variant, namely, c.464del (p.Pro155Hisfs*29). The patient received stroke rehabilitation, which significantly improved her functional state. Tumour necrosis factor inhibitor and methotrexate treatment was commenced, and the patient has remained stable with no further ischaemic events. Conclusions Although rare, ADA2 deficiency should be considered in patients with early-onset stroke, especially with concomitant manifestations of inflammatory features or immunodeficiency. This case report extends the genotypic spectrum of ADA2 deficiency.Item Systemic Juvenile Idiopathic Arthritis and Secondary Macrophage Activation Syndrome in Latvia from 2009 to 2020 : A Nationwide Retrospective Study(2023-04-20) Lukjanoviča, Kristīne; Šlēziņa, Ieva; Dāvidsone, Zane; Šantere, Ruta; Budarina, Kristīna; Staņēviča, Valda; Residency Unit; Rīga Stradiņš University; Department of PaediatricsBackground and Objectives: Systemic juvenile idiopathic arthritis (sJIA) is a distinctive JIA subtype with mostly nonspecific systemic clinical features, which can be a diagnostic challenge. This study aimed to analyze our experience with sJIA in Latvia for twelve years: assessing clinical and epidemiological characteristics, the efficacy of therapy, and disease outcomes, including the development of macrophage activation syndrome (MAS). Materials and methods: This is a descriptive study in which we conducted a retrospective case review of all patients with sJIA diagnosis admitted to the only pediatric tertiary centre in Latvia during the period 2009-2020. Results: sJIA was diagnosed in 35 patients with a mean annual incidence rate of 0.85 patients per 100,000 children. Major clinical signs at the first visit were: fever, rash, arthritis, and lymphadenopathy. Almost half of the patients, 48.5%, had a monocyclic disease course, and only 20% of patients had persistent disease. MAS developed in 28.6% of patients. Biological therapy was administered to 48.6% of patients, mostly by tocilizumab, which induced remission in 75% after one year, and in 81.2% after two years without any serious therapy-related complications. In our study, none of the patients had interstitial lung disease, drug reaction with eosinophilia and systemic symptoms (DRESS)-like syndrome, or fatal disease. Conclusions: The incidence and clinical characteristics of sJIA correlate with the literature findings, although MAS was more common than described in other studies. There is a tendency for the persistent disease to decrease with the use of biological therapy. Tocilizumab is an efficient choice of treatment with a good safety profile.Item Temporomandibular Joint Arthritis Development Influencing Factors, Clinical and Radiologic Symptoms in Children with Juvenile Idiopathic Arthritis. Summary of the Doctoral Thesis(Rīga Stradiņš University, 2018) Dāvidsone, Zane; Staņēviča, ValdaJuvenile idiopathic arthritis (JIA) is the most frequent rheumatologic disease in childhood. Any joint can be involved and also temporomandibular joints (TMJ). Longterm consequences of inflammation in these joints can be growth disturbancies with changes in shape and appearance and functional impairment of dentofacial region what in turn can lead to reduced quality of life. Magnetic resonance imaging (MRI) with contrast enhancement is the golden standard for diagnostics of TMJ arthriti. It is invasive and expensive method. To clarify those JIA patients who have indications for MRI it is important to understand factors what influence development of TMJ arthritis and also to know what subjective and/or objective symptoms are reflecting MRI findings. The objective of our study was to determine factors what influence development of TMJ arthritis including demographic, disease characterising clinical, laboratory and genetic factors and also to determine those clinical – subjective and objective symptoms what are connected with radiological symptoms. The study was prospective, cross sectional study consisting from four parts: 1) demographic and disease characterising clinical data of JIA patients group where analysed; 2) to determine factors what influences TMJ arthritis development different factors, including HLA II class alleles where analysed in two main study groups – with MRI findings consistent with TMJ arthritis and those without signs of arthritis in MRI; 3) patients subjective and objective TMJ symptoms where analysed in connection with MRI; 4) MRI results where analysed and compared in patients with TMJ arthritis symptoms and without them (asymptomatic patients). 91 JIA patients where included in the study to whom MRI of TMJ with contrast enhancement was done from years 2010 to 2015. 80 patients had subjective and/or objective TMJ arthritis symptoms and 11 JIA patients without symptoms where included. Factors what influence TMJ arthritis development including HLA II class alleles where analysed in two main groups according to MRI findings – 72 patients had MRI findings consistent with TMJ arthritis (MRI positive group) and 19 patients where with no arthritis signs in MRI (MRI negative group). HLA II class alleles DRB1, DQA1, DQB1 where genotyped in 91 JIA patients group and 100 healthy controls. From all demographic, disease characterising clinical and laboratory factors the only one who was statisticaly significant higher in MRI positive group was C-reactive protein (CRP). We found that there is genetic predisposition for development of TMJ arthritis. Till this there has been no studies about HLA II class alleles in JIA patients with TMJ arthritis. In our study risk for development of TMJ arthritis was found to be in patients with alleles DRB1*07:01, DRB1*13:01, DRB1*15:01. Alleles DRB1*08:01, DRB1*16:01, DRB*17:01 and DQB1*06:01 where found to be associated with less risk for development of TMJ arthritis. Alleles DQA1*05:01, DQB1*03:01 and DRB*11:01 were found to be connected with less risk for chronic inflammatory signs development in TMJ. It was found that there where more subjective and objective clinical symptoms in the group with active and chronic inflammatory signs combination in MRI of TMJ. Demographic, clinical and laboratory factors were analysed using logistic regression model and it was found that objective signs count predict positive MRI findings- if objective findings increased by one unit, probability for positive MRI findig was 2,3. There were more patients with active and chronic inflammatory signs in MRI of TMJ in the group of symptomatic patients than in patients with no subjective and/or objective TMJ arthritis signs. The study will help in the diagnostics of TMJ arthritis in JIA patients what further will help to decide about the treatment.Item Temporomandibulāro locītavu artrīta attīstību ietekmējošie faktori, klīniskie un radioloģiskie simptomi bērniem ar juvenilu idiopātisku artrītu. Promocijas darba kopsavilkums(Rīgas Stradiņa universitāte, 2018) Dāvidsone, Zane; Staņēviča, ValdaJuvenils idiopātisks artrīts (JIA) ir biežākā reimatoloģiskā slimība bērnu vecumā, kuras gadījumā iekaisums var skart jebkuru locītavu, tostarp arī temporomandibulārās locītavas (TML). Šo locītavu iekaisums var radīt ilgtermiņa sekas – dentofaciālus bojājumus un funkcionālus traucējumus, kas būtiski ietekmē pacienta dzīves kvalitāti. Zelta standarts temporomandibulāro locītavu artrīta diagnostikā ir magnētiskās rezonanses izmeklējums (MRI) ar kontrastvielu, kas ir invazīva, dārga metode. Lai noskaidrotu JIA slimnieku grupu, kuriem ir indikācijas MRI veikšanai, nepieciešams noskaidrot tos faktorus, kas ietekmē TML artrīta attīstību, kā arī zināt, kuri no subjektīvajiem un/vai objektīvajiem simptomiem biežāk asociējas ar artrīta atradi MRI. Darba mērķis bija noskaidrot TML artrīta attīstību ietekmējošos demogrāfiskos, slimību raksturojošos klīniskos, laboratoriskos un ģenētiskos faktorus, kā arī klīniskos (subjektīvos un objektīvos) un radioloģiskos simptomus un to savstarpējo saistību bērniem ar juvenilu idiopātisku artrītu. Pētījums bija prospektīvs, šķērsgriezuma, veidots no četrām daļām: 1) analizēti pacientu grupas demogrāfiskie un slimību raksturojošie rādītāji; 2) noteikti TML artrīta attīstību ietekmējošie faktori, tai skaitā HLA II klases alēles pacientu grupās ar TML artrīta pazīmēm MRI un bez tām; 3) analizēti subjektīvie un objektīvie simptomi un to saistība ar MRI; 4) analizēti MRI rezultāti un to atšķirības JIA pacientiem ar un bez TML artrīta subjektīvajiem un/vai objektīvajiem simptomiem. Pētījumā tika iekļauts 91 JIA pacients, kuriem laikā no 2010. līdz 2015. gadam veikts MRI ar kontrastvielu: 80 pacienti bija ar subjektīviem un/vai objektīviem TML artrīta simptomiem, bet 11 pacienti – bez simptomiem (asimptomātiski). TML artrīta attīstību ietekmējošie faktori, tai skaitā HLA II klases alēles, tika analizētas atkarībā no MRI atrades – 72 pacientiem tika konstatētas TML artrīta pazīmes, 19 pacientiem to nebija. Pētījuma pacientiem un 100 veselu indivīdu kontroles grupai tika veikta HLA II klases alēļu DRB1, DQA1, DQB1 genotipēšana. Līdz šim nav veikti pētījumi par HLA II klases alēlēm JIA slimniekiem ar TML artrītu. No visiem demogrāfiskiem, slimību raksturojošiem klīniskiem un laboratoriskiem TML artrīta attīstību ietekmējošajiem faktoriem CRP bija statistiski ticami augstāks pacientu grupā ar artrīta MRI atradi. Tika konstatēts, ka JIA ar TML artrītu pastāv ģenētiska predispozīja. Risks TML artrīta attīstībai bija pacientiem ar alēlēm DRB1*07:01, DRB1*13:01, DRB1*15:01, savukārt aizsargājoša ietekme bija alēlēm DRB1*08:01, DRB1*16:01, DRB*17:01 un DQB1*06:01. Tika konstatēts, ka DQA1*05:01, DQB1*03:01 un DRB*11:01 alēlēm ir mazāka saistība ar risku attīstīties hroniskām artrīta izmaiņām TML. Vērtējot subjektīvos un objektīvos simptomus pacientu grupās ar dažādu MRI atradi, tika noskaidrots, ka ticami vairāk subjektīvo un objektīvo sūdzību bija grupā ar aktīva un hroniska iekaisuma pazīmju kombināciju MRI. Saistība starp pozitīvu MRI atradi un demogrāfiskajiem, klīniskajiem un laboratoriskajiem rādītājiem tika noteikta, izmantojot loģistiskās regresijas modeli, kurā objektīvo simptomu skaits statistiski ticami prognozēja pozitīvu MRI atradi – objektīvo simptomu skaitam pieaugot par vienu simptomu, varbūtība, ka būs pozitīva MRI atrade, pieauga 2,3 reizes. JIA slimniekiem ar subjektīviem un/vai objektīviem TML artrīta simptomiem MRI atradē biežāk nekā asimptomātiskajiem slimniekiem bija aktīva un hroniska iekaisuma pazīmju kombinācija. Pētījuma rezultāti var palīdzēt TML artrīta diagnostikā un terapijas taktikas izvēlē slimniekiem ar juvenilu idiopātisku artrītu.Item Temporomandibulāro locītavu artrīta attīstību ietekmējošie faktori, klīniskie un radioloģiskie simptomi bērniem ar juvenilu idiopātisku artrītu. Promocijas darbs(Rīgas Stradiņa universitāte, 2018) Dāvidsone, Zane; Staņēviča, ValdaJuvenils idiopātisks artrīts (JIA) ir biežākā reimatoloģiskā slimība bērnu vecumā, kuras gadījumā iekaisums var skart jebkuru locītavu, tostarp arī temporomandibulārās locītavas (TML). Šo locītavu iekaisums var radīt ilgtermiņa sekas – dentofaciālus bojājumus un funkcionālus traucējumus, kas būtiski ietekmē pacienta dzīves kvalitāti. Zelta standarts temporomandibulāro locītavu artrīta diagnostikā ir magnētiskās rezonanses izmeklējums (MRI) ar kontrastvielu, kas ir invazīva, dārga metode. Lai noskaidrotu JIA slimnieku grupu, kuriem ir indikācijas MRI veikšanai, nepieciešams noskaidrot tos faktorus, kas ietekmē TML artrīta attīstību, kā arī zināt, kuri no subjektīvajiem un/vai objektīvajiem simptomiem biežāk asociējas ar artrīta atradi MRI. Darba mērķis bija noskaidrot TML artrīta attīstību ietekmējošos demogrāfiskos, slimību raksturojošos klīniskos, laboratoriskos un ģenētiskos faktorus, kā arī klīniskos (subjektīvos un objektīvos) un radioloģiskos simptomus un to savstarpējo saistību bērniem ar juvenilu idiopātisku artrītu. Pētījums bija prospektīvs, šķērsgriezuma, veidots no četrām daļām: 1) analizēti pacientu grupas demogrāfiskie un slimību raksturojošie rādītāji; 2) noteikti TML artrīta attīstību ietekmējošie faktori, tai skaitā HLA II klases alēles pacientu grupās ar TML artrīta pazīmēm MRI un bez tām; 3) analizēti subjektīvie un objektīvie simptomi un to saistība ar MRI; 4) analizēti MRI rezultāti un to atšķirības JIA pacientiem ar un bez TML artrīta subjektīvajiem un/vai objektīvajiem simptomiem. Pētījumā tika iekļauts 91 JIA pacients, kuriem laikā no 2010. līdz 2015. gadam veikts MRI ar kontrastvielu: 80 pacienti bija ar subjektīviem un/vai objektīviem TML artrīta simptomiem, bet 11 pacienti – bez simptomiem (asimptomātiski). TML artrīta attīstību ietekmējošie faktori, tai skaitā HLA II klases alēles, tika analizētas atkarībā no MRI atrades – 72 pacientiem tika konstatētas TML artrīta pazīmes, 19 pacientiem to nebija. Pētījuma pacientiem un 100 veselu indivīdu kontroles grupai tika veikta HLA II klases alēļu DRB1, DQA1, DQB1 genotipēšana. Līdz šim nav veikti pētījumi par HLA II klases alēlēm JIA slimniekiem ar TML artrītu. No visiem demogrāfiskiem, slimību raksturojošiem klīniskiem un laboratoriskiem TML artrīta attīstību ietekmējošajiem faktoriem CRP bija statistiski ticami augstāks pacientu grupā ar artrīta MRI atradi. Tika konstatēts, ka JIA ar TML artrītu pastāv ģenētiska predispozīja. Risks TML artrīta attīstībai bija pacientiem ar alēlēm DRB1*07:01, DRB1*13:01, DRB1*15:01, savukārt aizsargājoša ietekme bija alēlēm DRB1*08:01, DRB1*16:01, DRB*17:01 un DQB1*06:01. Tika konstatēts, ka DQA1*05:01, DQB1*03:01 un DRB*11:01 alēlēm ir mazāka saistība ar risku attīstīties hroniskām artrīta izmaiņām TML. Vērtējot subjektīvos un objektīvos simptomus pacientu grupās ar dažādu MRI atradi, tika noskaidrots, ka ticami vairāk subjektīvo un objektīvo sūdzību bija grupā ar aktīva un hroniska iekaisuma pazīmju kombināciju MRI. Saistība starp pozitīvu MRI atradi un demogrāfiskajiem, klīniskajiem un laboratoriskajiem rādītājiem tika noteikta, izmantojot loģistiskās regresijas modeli, kurā objektīvo simptomu skaits statistiski ticami prognozēja pozitīvu MRI atradi – objektīvo simptomu skaitam pieaugot par vienu simptomu, varbūtība, ka būs pozitīva MRI atrade, pieauga 2,3 reizes. JIA slimniekiem ar subjektīviem un/vai objektīviem TML artrīta simptomiem MRI atradē biežāk nekā asimptomātiskajiem slimniekiem bija aktīva un hroniska iekaisuma pazīmju kombinācija. Pētījuma rezultāti var palīdzēt TML artrīta diagnostikā un terapijas taktikas izvēlē slimniekiem ar juvenilu idiopātisku artrītu.