Browsing by Author "Bigestans, Andris"

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    Growth factors, apoptotic cells and barx1 gene in bone and soft tissue of skeletal class III patients
    (2007) Jankovska, Iveta; Pilmane, Mara; Urtane, Ilga; Bigestans, Andris; Salms, Girts; Lauskis, Gunars; Department of Orthodontics; Institute of Anatomy and Anthropology; Department of Oral and Maxillofacial Surgery and Oral Medicine
    Growth factors and growth stimulating genes are main signaling molecules for growth and development in ante- and postnatal period involved in cellular proliferation, differentiation and morphogenesis of tissues and organs during embryogenesis, postnatal growth and adulthood. The aim of this study was to evaluate TGF-beta (transforming growth factor-beta), BMP2/4 (bone morphogenetic protein 2/4), FGFR1 (fibroblast growth factor receptor one), barx1 gene and apoptosis from tissue samples of oro-maxillo-facial region in skeletal class III patients to reveal possible morphopathogenesis of severe skeletal anomalies. The study group included 9 patients with skeletal class III malocclusion. During orthognatic surgery tissue samples from tuber maxillae, ramus mandibulae anterior and posterior part, as well as gingiva from the lower jaw in region of second molar have been taken. Samples were stained with immunohistochemistry for TGF-beta, BMP2/4, FGFR1, apoptosis and barx1 gene. We used also the routine histological staining with haematoxyline and eosine. In tuber maxillae, ramus mandibulae anterior and posterior part staining for TGF-beta was the most relevant. Also BMP2/4, FGFR1 and barx1 showed the highest mean number of positive cells in tuber maxillae. Barx1 was equally expressed in ramus mandibulae, but BMP2/4 and FGFR1 mainly stained its posterior part cells. Apoptosis mostly affected ramus mandibulae anterior part. CONCLUSIONS: We suggest about more active stimulation of bone growth in tuber maxilla whereas ramus mandibulae. Apoptosis mainly affects ramus mandibulae anterior part that possibly connects to the lower expression of growth stimulating factors and may indicate lower bone remodelation ability.
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    Radiographic assessment of findings in the maxillary sinus using cone-beam computed tomography
    (2013) Dobele, Ilze; Kise, Ligija; Apse, Peteris; Kragis, Gints; Bigestans, Andris; Department of Otorhinolaryngology; Department of Prosthetic Dentistry
    OBJECTIVES. To assess the presence of anatomic variations and pathology of the maxillary sinus using cone beam computed tomography (CBCT) of the maxilla where pre- implant surgery is planned. MATERIAL AND METHODS. This retrospective study evaluates a sample CBCT scans of 34 dental patients (68 sinuses). CBCT is used to assess maxillary sinus mucosa and outflow and prevalence of septa. The mucosal thickening was measured and the sinus outflow was classified as open or obstructed. RESULTS. Mucosal thickening was found in 48.5%, septa in 20.6% and total opacity in 2.9% of the sinuses. Maxillary sinus outflow was blocked in 26.5% of the scans. Strong association between radiological signs of maxillary sinus ostium blockage and thickened mucosa was observed. CONCLUSIONS. Anatomic variations and lesions of the maxillary sinus were common findings in CBCT examinations of the maxilla required for dental preprosthetic planning. Routine CBCT scans, including maxillary sinus ostium are recommended for risk assessment prior to surgery.